<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01712

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceRKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYSCLHSFCLALQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDETDVSKPLQISHEPPLPACDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKSYNVNDNSFIETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMLYGVDQLTLDDIEKSVNDDMKRIIPWLQQLKFWLGQQRCKQSIKHLPTVSSETLQLANYASHPVGSLSKHKLFIKLTRLPQYYIVVEMFDVPGNPTELEYKYHFLSVSYAEGDDSPATALLLQQFKPNIEELVLDTKSGKQLKSGVKHKLSGDPCSIEPKKPKRSGEMCAFNKVLAHIVAMCDTNMPFIGLRLELSNMDIPHQGVQVEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPNHLNIFSEVRIYNYRKLILCYGTTKGSSISIQWNSILQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQAMPTSMPPPRKLPQRSWAASIPTVLTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTEALKCRVALNPKTNQTLQLKVTPENTGQWKSEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTTVPQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSPRPGECTIFAAVRDLMVNLTLPPGGRP
Length1378
PositionTail
OrganismNipponia nippon (Crested ibis) (Ibis nippon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Pelecaniformes> Threskiornithidae> Nipponia.
Aromaticity0.07
Grand average of hydropathy-0.194
Instability index54.68
Isoelectric point8.87
Molecular weight153048.09
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01712
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     311.10|      82|     284|     978|    1064|       1
---------------------------------------------------------------------------
  904-  976 (91.76/47.06)	..............P...PSPIG.GDMMDSLISQLQPQQ..PPQQPQQ..QPfAKQAgasGAYPlTS.PPT...SyhntvT......PSPSM.MHTQSP..GN..LHA.AS
  978- 1064 (149.12/96.25)	PSGALRAPSPASFGPT..PSPSSLGITMGQTANFASPHGtiDPSSPYTmmSP.SQRA...GNWP.GS.PQV...S.....G......PSPAArMPGMSP..ANPSLHSPVP
 1066- 1131 (70.22/34.01)	ASHSPRAGTSSQAMPTsmPPPRKL.............................PQR.....SWA.ASiPTVlthS.....AlnilllPSPT...PGLVPglAGSYLCSP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     315.91|     100|     208|     471|     577|       3
---------------------------------------------------------------------------
  471-  577 (160.44/117.91)	VVEMFDVPGNPTELEYKyhfLSVSYAEG.DDSPATALLLQQFK.PNIEELVL..DTKSGKQLK...SGVKHKLSGDPCSIEPKkpkrSGEMCAFNKVLAHIVAMCDTNMPFIGL
  682-  788 (155.47/97.04)	VVEMFLNDWNSIARLYE...CVLEFARSlPDIPNHLNIFSEVRiYNYRKLILcyGTTKGSSISiqwNSILQKFHISLGTVGPN....SGCSNCHNTILHQLQEMFNKTPNVVQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.94|      42|     478|     798|     878|       4
---------------------------------------------------------------------------
  799-  846 (62.87/83.94)	LNAINKLPTVPMLGLTQRTNTAYqCFSILPQSPTHIrlaFRNmyCIDI
 1203- 1244 (74.07/24.31)	LQVLEKFFETRVAGPPFKANTLI.AFTKLLGAPTHI...LRD..CVHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     258.83|      79|     149|     215|     299|       5
---------------------------------------------------------------------------
  215-  299 (128.89/99.84)	CLHSFCLALQLEvLHSQ..TLMLIRERWGDLVQVERYHAGKCLSLSVWNQQV...LGRKTGTASVHKVTIKIDETdvskpLQISHEPPLP
  366-  449 (129.94/85.30)	CGRSECLHVFVD.LHSGmfQLMLYGVDQLTLDDIEKSVNDDMKRIIPWLQQLkfwLGQQRCKQSIKHLPTVSSET.....LQLANYASHP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01712 with Med14 domain of Kingdom Metazoa
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