<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01697

Description Mediator of RNA polymerase II transcription subunit 12-like (Fragment)
SequenceQDELTAVNVKQGFSNQPAFSGDEHGSARNIVINASKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHNWFTDLAGSKPLTLLAKKVPILSKKEDVFAYLAKYSVPLLRAAWLIKMTCAYYAAISEAKIKKRQATDPNIEWTQIITRYLREQLAKVAEFYHATSSQGNSSVVMPQEMEQALKQWEYNEKLSFYMFQEGMLERHEYLTWILDVLEKIRPTDDDLLKLLLPLMLQYSEEFVQSAYLSRRLAYFCARRLSLLLSDGPSLVAAHSPHMIIGPSNPPLAAPSPTAPGPVVSPVQLACSDFLSCPQHRPLVYGLSCMLQTVTLCCPSALVWNYSTNENKNVNPGSPLDLLQVAPSSLPMPGGNSAFNQQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVMLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESLSSASLTGSSLPVFQNVLLRFLDTQAPSLSDPNSDHEKIEFVNLVLLFSEFTRHDVFSHDAYMCTLISRGDLSITATTRPRSPNGEAVDEHYSKDHDVKLEDHSIMEHMGIDSGTASIFDDVDKSDFKADFGSEFPVVTSEKSVKRERLRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRMILLYGVGKERDEARHQLKKITKDILKILNKKSTTEMGVGDEGQKARKTKQEAFPTLETVFTKLQQLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNSEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFLENPSAHSINYSMLGKILSDNAANRYSFVCNALMNVCMGHQDAGRINDIANLCAELTACCTVLSSEWLGVVKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVCLFPQGTEKLFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAILMLGDAEIGSNNVNSLKSEDFHMRGLLDELNEDEIWGSAHTLKSCGKAVSIETASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGIKECTEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCMKEPGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPNSVGNADTSNTRQNGKKTFLSSSERRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDVKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSNASQGGPEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHTHTKPKPRSYYLEPLPLPPEEEEEEPTTPVSQEPERKSGELSDQGKLATDDEKKTKGRKRKSKSSSRADVSS
Length1770
PositionKinase
OrganismEgretta garzetta (Little egret)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Pelecaniformes> Ardeidae> Egretta.
Aromaticity0.07
Grand average of hydropathy-0.309
Instability index49.30
Isoelectric point6.16
Molecular weight198088.62
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01697
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     381.10|     126|     148|     541|     687|       1
---------------------------------------------------------------------------
  469-  572 (131.71/113.64)	.................................PNDEAV.VMLLCEWAVSCKRSGKHRAMAV....AKLLEK.RQAEIEAERCGESEVLDEKESLSSASLTG....SSLPVFQNVLLRfldTQAPSLSDPNSDHEKIEfvNLVLLFS
  573-  714 (189.53/195.44)	EFTRHDVfshdaymcTLISRGDLSItatTRPRSPNGEAVDEHYSKDHDVKLEDHSIMEHMGIDSGTASIFDDvDKSDFKADFGSEFPVVTSEKSVKRERLRElifpSNYDLLRHLQYA...THFPIPLDESSSHECNQ..RMILLYG
  720-  779 (59.86/37.07)	DEARHQL........KKITKDILKI...LNKKSTTEMGVGDEGQKARKTKQEAFPTLETVFTKLQQLSYFD............................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.55|      24|      27|    1454|    1477|       2
---------------------------------------------------------------------------
 1454- 1477 (40.27/26.46)	VLTCL...KGQDE..QREGLLTSLQNQVN
 1479- 1507 (33.28/20.52)	ILSNWreeRYQDDvkARQMMHEALQLRLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.96|      30|     147|     875|     904|       3
---------------------------------------------------------------------------
  846-  869 (20.61/ 6.97)	.LLLKSSSLAGSYtTGLCVCIVAV..L......
  875-  904 (54.13/29.00)	CLILNSEQTAQVF.EGLCGVVKHV..VNPSECS
 1024- 1054 (48.22/25.12)	CTVLSSEWLG.VV.KALCCSSNHVwgFNDLLCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.32|      12|      27|    1105|    1118|       4
---------------------------------------------------------------------------
 1105- 1118 (20.23/19.84)	PGARMTCRllLHLF
 1135- 1146 (24.10/15.82)	PGIRSSCD..RHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.44|      13|      31|    1242|    1254|       9
---------------------------------------------------------------------------
 1242- 1254 (24.66/14.38)	CLKEPERLCTDKD
 1274- 1286 (26.78/16.28)	CYPHGIKECTEGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.95|      34|    1291|     363|     398|      14
---------------------------------------------------------------------------
  363-  398 (55.53/42.20)	SPLDLLQVAPSslPMPGGNSAFNQ.QVRAKIYEVEQQ
 1657- 1691 (61.41/40.55)	SPWDLFEGHKN..PAPLSWAWFGTvRVDRKVIKYEEQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01697 with Med12 domain of Kingdom Metazoa
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