<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01687

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceDDAMRKAGVAHNKSSKDMESHVFMKAKTREEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQNLTGGPPAGAPGMGMASRAQGTPMSGMSSLGPMGQQMSLPGQQQPPGTSGMAPHGMPGVSTATQQTQLQLQQIAQQQQQQQQQFQQQQVALQQQQFQAQQSAMQQQFQVQQQQAAAAAAAQQQQQQQQQLQAVQQQQQHMLKLQMQQQQQNQQQIQQQQQQQQLQRIAQMQQLQAAQAMQAQQQQQQQQQQQQQIPQQQIQQQPPPQQVMQQQMQQMQQQQQQQQQQQQQQQVAQAQQSQLPPQSQPQPQPMVSQPQAISGQIPKVLYSNQIHIFTSCFLFILKVRAQLVQQQQAAAAVQAAQAQAAQMGASGQVPILYSLLLLLILHFSTFQVSQNNITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGPPITAPVASPRKRKYEEDERQTIPNVLQGEVARLNPKFLVNLDPSHCSNNGTVHLICKLDDKNLPNVPPLQLSVPADYPDQSPLWIKNPRQYAANPFLQSVYRYMTSKLLQLPDKHSVTALLNTWAQSIRQACLSAA
Length762
PositionTail
OrganismEgretta garzetta (Little egret)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Pelecaniformes> Ardeidae> Egretta.
Aromaticity0.04
Grand average of hydropathy-0.748
Instability index86.29
Isoelectric point9.66
Molecular weight84653.16
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01687
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     273.19|      33|      33|     185|     217|       1
---------------------------------------------------------------------------
  141-  173 (51.26/ 8.82)	QQ........qQQQFQQQQV.ALQQQ..QFQAQQSAMQQQFQV.Q
  174-  215 (58.75/11.56)	QQqaaaaaaaqQQQQQQQQLQAVQQQ..QQHMLKLQMQQQQQN.Q
  216-  249 (54.40/ 9.97)	QQ........iQQQQQQQQLQRIAQM..QQLQAAQAMQAQQQQ.Q
  250-  284 (55.92/10.53)	QQ.........QQQQQQIPQQQIQQQppPQQVMQQQMQQMQQQ.Q
  285-  316 (52.86/ 9.40)	QQ.........QQQQQQQQ.Q.VAQA..QQSQLPPQSQPQPQPmV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     205.37|      43|      47|     407|     453|       3
---------------------------------------------------------------------------
   52-   92 (43.50/ 8.85)	.....QAS...VSDPMNALQNLTGGPPA.....GA....PG.....mgmasraqGTPMSGMSS
   94-  121 (42.59/ 8.51)	GPMGQQMS...LPGQ.QQPPGTSGMAPH.....GM....PG......................
  407-  445 (56.70/13.84)	...........SPSPVQQAQTPQSMPPP.....PQpqpsPQPGQPT........SQPNSNVSS
  446-  494 (62.58/16.06)	GPAPSPSSflpSPSP.QPSQSPAAARTPqnfsvPS....PGPLNTP........GNPNSVMS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.31|      29|      37|     519|     555|       4
---------------------------------------------------------------------------
  524-  555 (45.09/37.25)	INKIDKNEDrkkDLSKMKSLLDILTDPSKRCP
  556-  584 (52.22/24.22)	LKTLQKCEI...ALEKLKNDMAVPTPPPPPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.66|      14|      49|     318|     332|       5
---------------------------------------------------------------------------
  318-  332 (23.98/17.40)	QPQA...............ISGQIPkVLYS
  355-  383 (17.68/ 6.60)	QQQAaaavqaaqaqaaqmgASGQVP.ILYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.53|      14|      22|     656|     669|       7
---------------------------------------------------------------------------
  656-  669 (24.62/14.57)	VARLNPKFLVNLDP
  681-  694 (26.92/16.62)	ICKLDDKNLPNVPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01687 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IHNKKSQASVSDPMNALQNLTGGPPAGAPGMGMASRAQGTPMSGMSSLGPMGQQMSLPGQQQPPGTSGMAPHGMPGVSTATQQTQ
2) NNITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQ
46
400
130
512










Molecular Recognition Features






MoRF SequenceStartStop




NANANA