Description | Mediator of RNA polymerase II transcription subunit 1 (Fragment) |
Sequence | ETEKLNKMSTLLERLHAKYNQNRPWTETMKLVRQVMEKRVVMNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQNGLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVSCPELVQHLREKNFDEFSKHLRGLVNLYKLPGDNKLKTKMYLALQSLELDLSKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVILHENNVPRSLGMNVSVTVEGTMAMYKLPIAPLIMGSHPVDSKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQACTGIPLFDTPPTFVPLYELITQFELSKEADPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSTIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKENAPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGNKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPIPHSQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPATNEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDTDDFKGYASQALTTLGVQVLGADGGESKFKGGNQSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSGSNMAGPGVDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKMKSSKSEGSSGSKMSSSLYSSQGGSSSGQSKSSAQSVGKPGSSPITKHGLSSGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGEFQGKREKSDKEKSKVSVSGGSVDSSKKTSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDSLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHSMKPESWSKSPISAEQSLSMTSSAILSAERPSRASPEFLIGEEDDDLMDVALIGN |
Length | 1574 |
Position | Middle |
Organism | Egretta garzetta (Little egret) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Pelecaniformes> Ardeidae> Egretta. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.649 |
Instability index | 54.98 |
Isoelectric point | 8.88 |
Molecular weight | 167343.20 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP01679 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 7| 290.39| 41| 41| 1075| 1115| 1 --------------------------------------------------------------------------- 962- 1004 (38.29/ 8.74) VKEG.............NG.......SGS......nmagpgVDGKPGK..RSR...TPSSDGKSKEKLP..KRKKQ 1075- 1108 (49.72/14.15) ..........................SGS............VTSSSSKSHHSH...SSSSSSSSSSSTSG.KMKSS 1109- 1137 (36.16/ 7.73) KSEG............SSG..................................skmSSSLYSSQGGSSSG.QSKSS 1139- 1202 (35.98/ 7.65) QSVGkpgsspitkhglSSG.......SGStkmkpqgkpsslMNPSMSKPNISP...SHSRPSGGSDKLAS.PMKP. 1204- 1232 (33.08/ 6.27) ..........................PG..............TPPSSK...AK...SPISSGSGGSHMSG.TGSSS 1233- 1274 (52.65/15.54) SMKS............SSG.......MGS............SGSMSQKPPPSS...NSSTASSSSFSSSGsSMSSS 1373- 1419 (44.50/11.68) KNVG............STGvakiiisKHD............GGSPSIKAKVT....LQKPGEGGGDSLRP.QMASS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 5| 490.49| 108| 109| 527| 635| 2 --------------------------------------------------------------------------- 527- 609 (129.29/49.93) ..................................M....VKKN.........LPPASSPGYGMTTGSNPM....S..GTTTPTNTF.PGGPITTLFNMSISMKERH..DSVGHG..ED.F.SKV.......SQNPI.....LTSLLQITGNVGST 610- 726 (128.41/52.48) IGSSP......TPPHHTPPPVsSPASNTKNH..PMlmnlLKEN.........APQDFSTLYG....SSPLerqnS..SSGSPRMEMgPGGNKQK......KKKSRMpaDKPKHQteDD.F.QRElfsmdvdSQNPI.....FDV..NMTADTLDT 727- 838 (112.97/42.72) PHITPapsqcsTPPTTYPQPI..PHSQPSIQ..RM....VR...........LSSSDSIGADVTDILSDI....AeeASKLPATNE.DCPPIGTPVRDSSSSGHSQ..SALFDP..DV.FqTNN.......SENPYtdpadLIADAAV....... 839- 930 (87.27/30.89) ......................SPNSDSSNHffP.........dgvdfnpdlLNSQSQSGFGEEYFDE......S..SQSGDTDDF.KGYASQALTTLGVQVL......GADGG..ESkF.KGG.......NQSD.......TVDFSIIAAASKA 1308- 1344 (32.55/ 6.10) ........................................................SGPG.....GDDPM....D..GQMGPSSNS.SSHTMSSKHNMS.............GG..E..F.QG................................ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 146.75| 48| 100| 106| 156| 4 --------------------------------------------------------------------------- 106- 156 (80.27/58.65) LDPT..GLLCDVK..VAHHG..ENPVSCPeLVQHlrEKNFD.....EFSKHLRGLVNLYKLP 203- 261 (66.48/38.99) LTPRsgGLLMNLKyyVSPYDlfEDGTGAP.VILH..ENNVPrslgmNVSVTVEGTMAMYKLP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 143.53| 29| 98| 323| 351| 5 --------------------------------------------------------------------------- 273- 307 (36.53/17.97) DSK.GT..PSF.SS.ITsansvdlpaCFF...L.KFPR.PIPVS...R 323- 351 (53.75/30.22) DTP.PTFVPLY.EL.IT.........QFE...LSKEAD.PLPLN...H 371- 405 (29.12/12.69) DAPlPDGRSLQgTL.IS.........KIA...FQHPGRvPLILNlirH 425- 448 (24.13/ 9.15) DSP...........gIL.........QFEvcpLSDSCF.SVSFQ...H --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 183.19| 38| 81| 1434| 1471| 6 --------------------------------------------------------------------------- 1009- 1042 (42.63/12.90) ............KSPSHSSSnrP..FTPPASTGG...SKSpGSS....GRS.QTPP 1434- 1471 (70.55/26.01) HER.........CSPSHSKS..P.AYTPQNIDSE...SES.GSSI..AEKSYQNSP 1481- 1502 (30.18/ 7.05) PEY.........SSEKHKK..............H...KKE.KKKV..KDK.....D 1503- 1555 (39.83/11.58) RDRdrdrdkdrdKKKSHSMK..PeSWSKSPISAEqslSMT.SSAIlsAERPSRASP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FGEEYF 2) IPKITIQIPKGT 3) IRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRD 4) LSAER 5) NKKPSLTAVIDKLKHGVV 6) RASPEFLIGEEDDDLMDVALIGN 7) SIKAKVTLQK 8) VAKIIISKH 9) YGSPLI | 868 1049 1477 1545 1289 1552 1394 1380 1422 | 873 1060 1508 1549 1306 1574 1403 1388 1427 |
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