<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01677

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceAELTGIKWRRYNFEGHGDCGPIISAPAQDDPILLSFIRCLQNNLLCVWRRDVKPDCKELWIFWWGDEPNLVDVIHRELHMVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFIRPYDKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIQMAQSSPSPFQVLVSPYGLNGTLTGQSYKMSDPATRKLMEEWQYFYPMVLKKKEGMKEEEELGYDNDFPVAVEVIVGGVRMVYPSAFVLISQSDIPMSQNAANTGGHINVGQQGLGSMKDPASTCGMPLTPPTSPEQAVMGESGCSQSSSSHSAVQEGTVSVHSPKKSGKITPKFHNHMVQRVWKECILNRSQSKRNQITAASLEEEVPNNTVTWDFVDPVQRASCSCSRHKVLKQRGAAGSSRPPALSQPGFSVGTAASAALPPPASSKHKTTERQEKGEKLQKRPMMPFHHRPSVTEELCMEQDTSGQKLGLAGMDPSLEVPSSRKYEKPLSIPARNPSKQISMNPMDSPRSPTSPLPPTLSPQPRGQEAENLDPPSVPVNPALYGSGLELQPLPSLDDRTVLVGQRLPLMAEVSETALYCGIIQNNEALDMWRTYSVPSSDDPEFRPPDLPCERYDAKMETHSDSTALKRLLAQPNKRFKILEEQKPVQPLNYLDPLPLIQQPGEGLGDASDPYTFEDGDIKYSFTGNKKCKLGAEKDPLKKNKSEDGIGTKEIPTTGHSTPVPDGKDAMSIFSTAPKTDTRQDNAAGRVGSGSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKLPPVGSEERPVGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTTLGMMESPMVNMVPTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSLFAPLKILPSQCLLPLKIPDACIFRPSWAVPPKIEQLPLPPAATFIRDGYNNVPSVGSLADQDYLQMSTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPGTVQPIPEAHSLYVTLILSDSVLNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFIEDELDIFGKTSDIGQAAERRLMICQSNFISQMGEGARRSQEPPMSLLLLLQNQHTQPFTSLSCLDYMASNNRQALPCVNWSYDRLQADSNDSWVECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLDGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKSVAQKLTDELVSEWFSQPWGSEEADNHSRLKLYAQVCRHHLAPYLATLQLDSSLLLPPKYQTPAPANQTQTVPGNTGSGPGSSNPTCLPAAGAPPTGSSLNSTPSGGTTSLPVGSSSSSGSSVPQLSASSATPGVSQMATTSTPGFSGNTGSGQNTSTGGNAADRSQGSTGPGGDTEPGQTLPQQPQEGQEGVTERERIGVPTEPESADSNAYPPAVVIYMVDPFTYTADEESASTNFWLLSLMRCYTEMLDNLPENMRNSFILQIVPCQYMLQTMKDEQVFYIQHLKSLAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIDLPNRSRRSKLSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKEVCRMCGISSADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQSSQLNTPQDASCTHILVFPTSATIQVAPANYPNEDGFSPTNDDMFDLPFPDDMDNDIRILITGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRSSCLPVHFVVLTQLYNAIMNIL
Length2195
PositionMiddle
OrganismCalypte anna (Anna's hummingbird) (Archilochus anna)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Caprimulgimorphae> Apodiformes> Trochilidae> Calypte.
Aromaticity0.07
Grand average of hydropathy-0.396
Instability index58.33
Isoelectric point5.57
Molecular weight240903.00
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01677
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.79|      14|      16|     538|     552|       1
---------------------------------------------------------------------------
  538-  552 (23.92/14.67)	PQPRGQEAEnLDP.PS
  557-  571 (22.87/ 9.22)	PALYGSGLE.LQPlPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.36|      26|      27|    1010|    1035|       2
---------------------------------------------------------------------------
  979-  999 (25.62/ 8.36)	..GSLADQDYLQMSTPQMNTP.VT...
 1010- 1035 (46.42/21.50)	GAGVLPSPATPRFSVPTPRTP.RTPRT
 1038- 1064 (38.31/16.38)	GGGTASGQGSVKYDSTDQGSPaSTPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.35|      15|      17|    1617|    1633|       3
---------------------------------------------------------------------------
 1627- 1642 (21.33/11.04)	TLPQQPQeGQEGVTER
 1646- 1660 (24.02/ 6.95)	GVPTEPE.SADSNAYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.44|      12|      19|    1594|    1605|       4
---------------------------------------------------------------------------
 1594- 1605 (23.62/ 9.17)	GNTGSGQNTSTG
 1614- 1625 (24.82/10.05)	GSTGPGGDTEPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.28|      16|      19|    1541|    1556|       5
---------------------------------------------------------------------------
 1541- 1556 (28.79/15.20)	PTGSSL...NSTPSGGTTS
 1558- 1576 (20.49/ 8.19)	PVGSSSssgSSVPQLSASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.09|      27|      27|     443|     469|       6
---------------------------------------------------------------------------
  443-  469 (49.95/36.05)	KHKTTERQEKGEKLQKRPMMPFHHRPS
  472-  498 (47.14/33.46)	EELCMEQDTSGQKLGLAGMDPSLEVPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.51|      12|      17|    1224|    1235|       7
---------------------------------------------------------------------------
 1224- 1235 (21.88/13.89)	ASNNRQALPCVN
 1243- 1254 (23.63/15.70)	ADSNDSWVECFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.40|      18|      20|     936|     954|       9
---------------------------------------------------------------------------
  936-  954 (32.67/20.35)	LPLKiPDACIFRPSWAVPP
  959-  976 (34.73/17.50)	LPLP.PAATFIRDGYNNVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.51|      14|      20|    1353|    1366|      12
---------------------------------------------------------------------------
 1353- 1366 (27.59/17.90)	SPEPLPI..PTLLVGY
 1374- 1389 (22.92/13.15)	SPFSLPFweRLLLDPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.55|      19|      24|     774|     797|      13
---------------------------------------------------------------------------
  774-  797 (23.33/28.03)	VtdlAPSLHD..LDNIfdNSDEDELG
  799-  819 (29.22/16.15)	V...SPALRSskLPPV..GSEERPVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.57|      27|      27|    1844|    1870|      14
---------------------------------------------------------------------------
 1844- 1870 (47.29/30.53)	IDLPNRSRRSKLS.ARKIGLQKLWEWCI
 1873- 1900 (43.27/27.24)	VQMTSLPWRVVIGrLGRLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.66|      20|      21|    1673|    1693|      15
---------------------------------------------------------------------------
 1673- 1693 (30.76/27.04)	YTADE..ESASTNFwLLSLMRC.Y
 1695- 1717 (27.90/17.04)	EMLDNlpENMRNSF.ILQIVPCqY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.13|      25|      26|      36|      60|      17
---------------------------------------------------------------------------
   36-   60 (49.31/30.65)	FIRCLQNNLLCVWRRDVKPDCKELW
   62-   86 (47.82/29.48)	FWWGDEPNLVDVIHRELHMVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.73|      10|      15|    1509|    1519|      19
---------------------------------------------------------------------------
 1509- 1519 (14.82/10.44)	PAPANQTqTVP
 1526- 1535 (20.91/10.33)	PGSSNPT.CLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.90|      18|      25|    1093|    1110|      20
---------------------------------------------------------------------------
 1093- 1110 (35.55/22.34)	DSVLNIFKDRNFDSC.CIC
 1120- 1138 (31.35/18.77)	DVGLYIPDSSNEDQYrCTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.57|      58|    1267|     132|     191|      21
---------------------------------------------------------------------------
  132-  191 (98.89/69.09)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHI.QMAQSSPSPF.QVLVS.....PYG
 1402- 1466 (89.67/54.41)	PENEA.LLDGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGImRVGKSVAQKLtDELVSewfsqPWG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.26|      17|      17|     263|     279|      23
---------------------------------------------------------------------------
  263-  279 (29.35/16.35)	ISQSDIPMSQNAANTGG
  283-  299 (30.91/17.66)	VGQQGLGSMKDPASTCG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.63|      14|      17|    1986|    2001|      24
---------------------------------------------------------------------------
 1986- 2001 (20.72/18.31)	PTSATIQVAPanYPNE
 2006- 2019 (27.91/17.33)	PTNDDMFDLP..FPDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.53|      16|      40|     344|     360|      25
---------------------------------------------------------------------------
  344-  360 (28.31/30.15)	ITPKFHNHmVQRVWKEC
  386-  401 (32.22/26.97)	VTWDFVDP.VQRASCSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.89|      44|    1322|     715|     764|      26
---------------------------------------------------------------------------
  715-  764 (63.31/50.95)	PLKKNKSEDGIGTKeiPTTGHSTpvPDGKDAMSifSTAPKTDTRQDNAAG
 2040- 2083 (78.57/43.98)	PVPSPGSPSGIGVG..SHFQHSR..SQGERLLS..REAPEELKQQPLALG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01677 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CSRHKVLKQRGAAGSSRPPALSQPGFSVGTAASAALPPPASSKHKTTERQEKGEKLQKRPMMPFHHRPSVTEELCMEQDTSGQKLGLAGMDPSLEVPSSRKYEKPLSIPARNPSKQISMNPMDSPRSPTSPLPPTLSPQPRGQEAENLDPPSVPVNPALYGSGLELQ
2) GAEKDPLKKNKSEDGIGTKEIPTTGHSTPVPDGKDAMSIFSTAPKTDTRQDNAAGRVGSGSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKLPPVGSEERPVGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPV
3) GSLADQDYLQMSTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPGTVQ
4) KDPASTCGMPLTPPTSPEQAVMGESGCSQSSSSHSAVQEGTVSVHSPKKSGKITPKF
5) LPPKYQTPAPANQTQTVPGNTGSGPGSSNPTCLPAAGAPPTGSSLNSTPSGGTTSLPVGSSSSSGSSVPQLSASSATPGVSQMATTSTPGFSGNTGSGQNTSTGGNAADRSQGSTGPGGDTEPGQTLPQQPQEGQEGVTERERIGVPTEPESA
6) MWRTYSVPSSDDPEFRPPDLPCERYDAKMET
7) NLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
401
710
979
292
1502
607
2031
567
854
1077
348
1654
637
2073










Molecular Recognition Features






MoRF SequenceStartStop




NANANA