<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01670

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceRKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYSCLHSFCLALQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDETDVSKPLQISHEPPLPACDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKSYNVNDNSFIETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMLYGVDQLTLDDIEKSVNDDMKRIIPWLQQLKFWLGQQRCKQSIKHLPTVSSETLQLANYASHPVGNLSKHKLFIKLTRLPQYYIVVEMFDVPGNPTELEYKYHFLSVSYAEGDDSPATALLLQQFKPNIEELVLDTKSGKQMKSGVKRKLSGDPCSIEPKKPKRSGEMCAFNKVLAHIVAMCDTNMPFIGLRMELSNMDIPHQGVQVEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPNHLNIFSEVRIYNYRKLILCYGTTKGSSISIQWNSILQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQAMPTSMPPPRKLPQRSWAASIPTVLTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTEALKCRVALNPKTNQTLQLKVTPENTGQWKSEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTTVPQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSPRSG
Length1355
PositionTail
OrganismEgretta garzetta (Little egret)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Pelecaniformes> Ardeidae> Egretta.
Aromaticity0.07
Grand average of hydropathy-0.209
Instability index54.66
Isoelectric point8.92
Molecular weight150667.31
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01670
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     304.40|      53|      57|     985|    1037|       1
---------------------------------------------------------------------------
  904-  948 (48.31/17.95)	.......P...PSPIG.GDMMDSLISQLQPQQ..PPQ..QPQQ..QPfAKQAgasGAYPlTS
  949-  975 (48.88/18.24)	P.PTS.....................Y...HNTVTP...SP.SMMH..TQSP...GNLH.AA
  985- 1037 (103.93/46.75)	PSPASFGPT..PSPSSLGITMGQTANFASPHGTIDPS..SPYTMMSP.SQRA...GNWP.GS
 1043- 1073 (42.91/15.15)	PSPAARMPG..MSPA...................NPSlhSPVPDASH.SPRA...G......
 1074- 1122 (60.37/24.19)	.TSSQAMPTsmPPPRKL....PQRSWAASIPTVLTHS..ALNILLLP.SPTP...GLVP.G.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     425.46|     190|     509|      69|     305|       2
---------------------------------------------------------------------------
   69-  167 (90.43/86.41)	................................................................................................................................................................................................................................................................LPSFAIPY.AIDVLTTGsyprLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVAN......................................grvkfrvegeFEATLTVMGDDPDIPWRL
  183-  299 (128.24/97.62)	RALVHSMQIN...FIHQLVQSRLFADEKPlqdmysCLHSFCLALQLEvLHSQ..TLMLIRERWGDLVQVERYHAGKCLSLSVWNQQV...LGRKTGTASVHKVTIKIDETdvskpLQISHEPPLP.............................................................................................................................................................................................................................................................................
  337-  449 (128.84/64.31)	KAILKSYNVNdnsFIETALPTLVIPILEP......CGRSECLHVFVD.LHSGmfQLMLYGVDQLTLDDIEKSVNDDMKRIIPWLQQLkfwLGQQRCKQSIKHLPTVSSET.....LQLANYASHP.............................................................................................................................................................................................................................................................................
  581-  714 (77.95/30.17)	.............................................................................................................................vgnlskhklfikltrlpqyyivvemfdvpgnpteleykyhflsvsyaegddspatalllqqfkpnieelvldtksgkqmksgvkrklsgdpcsiepkkpkrsgemcafnkvlahivamcdtnmpfiglrmeLSNMDIPHqGVQVEGDG....FSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANcplnstssreqgptrhvyltyenqlsepvggrkvvemflndwnsiarlYECVLEFARSLPDIPNHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.13|      19|      52|     755|     774|       5
---------------------------------------------------------------------------
  755-  774 (34.45/25.34)	LGTVgPNSGCSNCHNT......ILHQ
  805-  829 (29.68/16.13)	LPTV.PMLGLTQRTNTayqcfsILPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01670 with Med14 domain of Kingdom Metazoa
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