<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01662

Description Mediator of RNA polymerase II transcription subunit 12-like (Fragment)
SequenceQDELTAVNVKQGFSNQPAFSGDEHGSARNIVINASKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFTDLAGSKPLTLLAKKVPILSKKEDVFAYLAKYSVPLLRAAWLIKMTCAYYAAISEAKIKKRQATDPNIEWTQIITRYLREQLAKVAEFCHATSSQGNSSVVMPQEMEQALKQWEYNEKLSFYMFQEGMLERHEYLTWILDVLEKIRPTDDDLLKLLLPLMLQYSEEFVQSAYLSRRLAYFCARRLSLLLSDGPNPVAAHPPHGILGPSNPPLAAPSPTAPAPGVAPLQLSCSDFLSCPQHRPLVYGLSCMLQTVTLCCPSALVWNYSTNENKNINPGSPLDLLQVAPSSLPMPGGNSAFNQQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQNKDNQEVATSDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESLSSASLTGSSLPVFQNVLLRFLDTQAPSLSDPNSDHEKTEFVNLVLLFSEFTRHDVFSHDAYMCTLISRGDLSITAATRPRSPHGDEHYSKDHDVKLEDHSIVEHIDSGTAGVFDDVDKGDFKADFGSDFPVATSEKSVRRERLGDVIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRMILLYGVGKERDEARHQLKRITKDILKILNKKSTTEMGVGDEGQKARKTKQETFPTLETVFTKLQQLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILSPEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSRFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMMDFIENPSAHSINYSMLGKILSDNAANRYSFVCNALMNVCMGHQDAGRINDMANLCAELTACCTVLSSEWLGVVKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVCLFPQGAGKFFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAILMLGDAEIGSNNINSSLKGEDFQMRGLLDELSEDGVWGSSHTLKSCGKAVSIETASLSEYARYVLRTICQQEWIGEHCLKEPERLCTDKDLILDPVLSNKQAQTLLQLICYPHGVTECTEGENPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCLKEPGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPNSVGNADTSNTRQNGKKAFLSSSERRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDVRARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSSASQGGPEENKRAYMNLVKKLKKELGDKRSASIDRVRQLLPLPKQTCDIIACEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHTHTKPKPRSYYLEPLPLPPEEEEEEPTTPVSQEPERKSGELSDQGKLATEDEKKTKGRKRK
Length1755
PositionKinase
OrganismCalypte anna (Anna's hummingbird) (Archilochus anna)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Caprimulgimorphae> Apodiformes> Trochilidae> Calypte.
Aromaticity0.07
Grand average of hydropathy-0.299
Instability index50.87
Isoelectric point6.16
Molecular weight195918.00
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01662
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     464.00|     133|     150|    1040|    1189|       1
---------------------------------------------------------------------------
  971- 1038 (77.98/43.43)	...................................................SMLGKILSDNA..ANR..YSFVCNALMN......VCMGHQDAGR.IND...MANLCAE..LTAC.CTVLSSEWLGVVKALCCSSN..........................
 1040- 1189 (205.53/176.81)	VWGFNDLL..CSVDVSdlsFHD.SLATFIAILIARQCfSLEDVVQH.VALPSLLAAACGDPD..AEP.GARMTCRLLLHLfrtpqVCLFPQGAGKFFPG...IRSSCDRHLLAAAHNSIEVGAVFAVLKAILMLGD..AEIGSNNINsslkgedfQMRGLLD
 1196- 1332 (180.49/119.71)	VWGSSHTLksCGKAVS...IETaSLSEYARYVLRTIC.QQEWIGEHcLKEPERL...CTDKDliLDPvLSNKQAQTLLQL.....IC.YPHGVTECTEGenpQRQHIKRIL....QNLDQWTLRQSWLELQLMIKQclKEPGSGSVA........EMNSLLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.43|      32|     150|     620|     656|       4
---------------------------------------------------------------------------
  590-  625 (51.74/37.02)	ISRGdlsiTAATRPRSPHGD..EHYSKDHDVKLEDHSI
  629-  662 (49.69/33.79)	IDSG....TAGVFDDVDKGDfkADFGSDFPVATSEKSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     209.03|      62|     156|    1389|    1453|       6
---------------------------------------------------------------------------
 1389- 1450 (100.14/67.19)	GVWLVAPLIAKLP..TSVQGRVLKAAG.EELEKGQHLG.SSSKKERDRQKQKSMSLLSQQPFLSLV
 1552- 1607 (86.53/56.31)	GVLINGTLASDLS..SASQG......G.PEENKRAYMN.LVKKLKKELGDKRSASIDRVRQLLPLP
 1613- 1651 (22.36/16.81)	.......IIACEPmgSLIDTKGNKIAGfDSIDKKQARGlQVSTKQK....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.14|      26|     270|     673|     701|       7
---------------------------------------------------------------------------
  673-  701 (43.83/36.82)	PSNYDLLRHLQYATHFpipLDESSSHECN
  944-  969 (50.31/32.34)	PSNSNLLWDPEFMMDF...IENPSAHSIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.93|      10|      15|     307|     316|       8
---------------------------------------------------------------------------
  307-  316 (20.66/11.32)	PGVAPL..QLSC
  323-  334 (17.27/ 8.15)	PQHRPLvyGLSC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01662 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RSYYLEPLPLPPEEEEEEPTTPVSQEPERKSGELSDQGKLATEDEKKTKGRKRK
1702
1755










Molecular Recognition Features






MoRF SequenceStartStop




1) PRSYYLEPLPLPPEEEEEEPTTPVSQEPERKSGELSDQGKLATEDEKKTKGRKRK
1701
1755