Description | Mediator of RNA polymerase II transcription subunit 1 (Fragment) |
Sequence | ETEKLNKMSTLLERLHTKYNQNRPWTETMKLVRQVMEKRVVMNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQNSLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVSCPELVQHLREKNFDEFSKHLRGLVNLYKLPGDNKLKTKMYLALQSLELDLSKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVILHENNVPRSLGMNVSVTVEGTMAMYKLPIAPLIMGSHPVDSKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQGCTGIPLFDTPPTFVPLYELITQFELSKEADSLPLNHNMHFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSAIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGNKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPIPHSQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPTTNEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDTDDFKGYASQALTTLGVQVLGADGGENKFKGSAQSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLSTGDLGEKSQKRVKEGNGSGSNLAGPGIDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSSKSEGSSGSKMSSSLYSSQGSSSSGQSKSSAQSVGKPGSSPITKHGLSSGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPTGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSCGSMSQKPPPSSNSSTASSSSFSSGGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQLGPSSNSSSHTISSKHNMSGGEFQGKREKSDKEKSKVSVSGGAVDSSKKTSDSKSVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDSLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSMKPESWSKSPISADQSLSMTSSTILSAERPSRASPEFLIGEEDDDLMDVALIGN |
Length | 1571 |
Position | Middle |
Organism | Calypte anna (Anna's hummingbird) (Archilochus anna) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Caprimulgimorphae> Apodiformes> Trochilidae> Calypte. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.633 |
Instability index | 54.37 |
Isoelectric point | 8.81 |
Molecular weight | 166918.68 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP01644 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 11| 1033.11| 109| 109| 1105| 1213| 1 --------------------------------------------------------------------------- 534- 616 (59.19/10.64) ......PA..SSP.......GYGM.TTG.......................................................SNPMSGT..................TTP.TNTFPGGPittlfnmsISMKER...............hdsvgHGE...DFSKV.........SqnpilTSLLQIT..GNvgSA..IG..SSPTP 617- 720 (96.49/21.91) PHHTPPPV..SSP................ASNT.KNHP..M.........LMN.....LLK.EN............PPQD...FSTLYGSSP........LerqnsssGSPrMEMGPGGN........KQKKKKS.......rmPADKP.....KHQ...TEDDF.........Q.....RELFSMD..VD..SQ..NPifDVNMT 721- 822 (100.30/23.06) ADTLDTPH..ITP..A...P.....SQC.STPP.TTYP..QP...IPHS...QPS...IQRmVRL...........SSSD...SIGADVTDI........L.......SDI.AEEASKLP........TTNEDCP...pigtpvRDSSS.....SGH...SQSAL........fD.....PDVF.................QTNNS 823- 946 (85.22/18.50) ENPYTDP...ADL..I...ADAAV.SPN.SDSSnHFFP..DGvdfNP.D.LLN.S...QSQ.SGF...........GEEYfdeSSQSGDTDDfkgyasqaL.......TTL.GVQVLGA.........DGGENKF.........K..........GS...AQSDTvdfsiiaaaS.....KALGSSDimEH..HS..GG..Q..SP 947- 1038 (69.51/13.76) LLSTGDLGekSQK..R...VKEG...NG.SGSN.LAGPgiDG...KPGKrSRTPSsdgKSK.EKLpkrkkqetdgkSPSH...S.........................SS.NRPF..TP........PASTGGS.........KSPGS.....SGR............................SQ................... 1039- 1136 (108.77/25.62) ..T..PPGvaTPP..I...PKITI.QIP.KGTV.TV.....G...KPSS...........H.GQY...........TSSG...SVTSSSSKS........H.......HS.........H........SSSSSSSsssstsgkiKSSKS.....EGS...SGSKM.........S.....SSLYSSQ..GS..SS..SG..QSKSS 1137- 1235 (169.65/44.01) AQSVGKPG..SSP..I...TKHGL.SSG.SGST.KMKP..QG...KPSS.LMNPS...MSK.PNI...........SPSH...SRPTGGSDK........L.......ASP.MKPVPGTP........PSSKA...........KSPIS.....SGS...GGSHM.........S.....GT.......GS..SS..SM..KS... 1236- 1287 (75.98/15.71) ..........SS..........G..M....GSC........G............S...MS...................Q.................................K..P..P........PSSNSST.........ASSSS.....FSS...GGSSM.........S.....SS..QNQ..HG..SS..KG..KSPSR 1288- 1370 (80.19/16.99) NK...KPS..LTA..VidkLKHGVvTSGpGGDD.PMDG..QL...GPSS.....N...SSS.HTI...........SSKH...N..MSGGE.....................FQ..GKRE........KSDKEKS.........KVS.....................................VSG..GA..VD..SS..KKTSD 1371- 1450 (88.17/19.39) SKSVGSTG..VAKiiI...SKH...DGG.SPSI.KAK................VT...LQK.PG......................EGGGDS........L..............................RPQM.........ASSKS.....YGSpliSGSTP.........K.....HERCSPS..HS..KS..PA..YTPQN 1451- 1549 (99.64/22.86) IDSESESG..SSI..A...EKSYQ.NSP.SSDD.GIRP..LP...EYSS.EKHKK...HKK.EKK...........KVKD...KDRDRDRDK.....................................DRDKKK........sHSMKP.....ESW...SKSPI.........S.....ADQSLSM..TS..STilSA..ERPSR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 286.17| 82| 98| 323| 406| 2 --------------------------------------------------------------------------- 294- 347 (82.03/52.69) .....................CFFLKFPRPIPVSRAF....IQKL..QGCTGIPL.........................fDTPPTFVPLYEL.ITQFELSKEADSL 348- 441 (110.03/84.24) PLNHNMhFYAALPGQQ..H..CYFLNKDAPLPDGRSLQGTLISKIAfQHPGRVPLILNLIRHQvayntligscvkrtvlkeDSP.........gILQFEVCPLSDSC 449- 522 (94.11/62.05) PVNDSL.VCVVMDVQDstHvnCK.LYKG..LSDALICTDDFIAKVV.QRCMSIPVTMRAIRRK.................aETIQADTPALSL.IAE.......... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 237.88| 77| 102| 106| 193| 3 --------------------------------------------------------------------------- 106- 193 (121.05/98.49) LDPT..GLLCDVK..VAHHG..ENPVSCPeLVQHlrEKNFD.....EFSKHLRGLVNLYKLPgdnklktKMYLALQSLELDlSKMAGMYWQATNANPLD 203- 290 (116.84/69.55) LTPRsgGLLMNLKyyVSPYDlfEDGTGAP.VILH..ENNVPrslgmNVSVTVEGTMAMYKLP.......IAPLIMGSHPVD.SKGTPSFSSITSANSVD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FGEEYF 2) IPKITIQIPKGT 3) IRPLPEYSSEKHKKHKKEKKKVKDKDRDR 4) NKKPSLTAVIDKLKHGVV 5) RASPEFLIGEEDDDLMDVALIGN 6) SIKAKVTLQK 7) VAKIIISKH 8) YGSPLI | 868 1048 1476 1288 1549 1393 1379 1421 | 873 1059 1504 1305 1571 1402 1387 1426 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab