<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01635

Description Mediator of RNA polymerase II transcription subunit 12-like (Fragment)
SequenceQDELTAVNVKQGFSNQPAFSGDEHGSARNIVINASKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHNWFTDLAGSKPLTLLAKKVPILSKKEDVFAYLAKYSVPLLRAAWLIKMTCAYYAAISEAKIKKRQATDPNIEWTQIITRYLREQLAKVAEFYHVTASQGNSSGVMPQEMEQALKQWEYNEKLSFYMFQEGMLERHEYLTWILDVLEKIRPTDDDLLKLLMPLMLQYSEEFVQSAYLSRRLAYFCARRLSLLLSDGPNLVAAHSPHVIIGPSNPPLAAPSPTAPGPVVSPVQLACSDFLSCPQHRPLVYGLSCMLQTVTLCCPSALVWNYSTNENKNINPGSPLDLLQVAPSSLPMPGGNSAFNQQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVMLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEALDEKESLSSASLTGSSLPVFQNVLLRFLDTQAPSLSDPNSDHEKTEFVNLVLLFSEFTRHDVFSHDAYMCTLISRGDLSITTTTRPRSPNGEAVDEHYSKDRDVKLEDHSIMEHMGIDSGTTGIFDDVDKSDFKADFGSEFPVVTSEKSIKRERLRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRMILLYGVGKERDEARHQLKKITKDILKILNKKSTTEMGGLFSDGTWLSVVFLFGDEGPKARKTKQEAFPTLETVFTKLQQLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNSEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSAHSINYSMLGKILSDNAANRYSFVCNALMNVCMGHQDAGRINDIANLCAELTACCTVLSSEWLGVVKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVCLFPQGTGKLFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAILMLGDAEIGSNNVNSLKSEDFSVRGLLDELNEDEIWGSSHTSKSCGKPVSIETASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGIKEYTEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCMKEPGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPNSVGNADTSNTRQNGKKTFLSSSERRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDVKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSNASQGGPEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQARINGLQVSTKQKISPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHTHTKPKPRSYYLEPLPLPPEEEEEEPTTPVSQEPERKSGELSDQGKLAMDDEKKTKGRKRKSKSSSRADVS
Length1785
PositionKinase
OrganismCuculus canorus (common cuckoo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Cuculiformes> Cuculidae> Cuculus.
Aromaticity0.07
Grand average of hydropathy-0.305
Instability index48.61
Isoelectric point6.16
Molecular weight199754.48
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01635
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.02|      36|     147|     541|     578|       1
---------------------------------------------------------------------------
  541-  578 (58.67/42.50)	LLRFLD..TQAPSLSDPNSDHEKTEfvNLVLLFS.....EFTRHD
  683-  725 (55.35/33.52)	LLRHLQyaTHFPIPLDESSSHECNQ..RMILLYGvgkerDEARHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.64|      30|     147|     889|     918|       2
---------------------------------------------------------------------------
  889-  918 (54.87/39.91)	CL..ILNSEQTAQVFEGLCGVVKHV..VNPS....ECS
 1038- 1068 (45.91/31.98)	CT..VLSSEWLG.VVKALCCSSNHVwgFNDL....LCS
 1079- 1112 (29.87/17.79)	SLatFIAILIARQCF.SLEDVVQHV..ALPSllaaAC.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.04|      38|     733|     481|     518|       5
---------------------------------------------------------------------------
  481-  518 (67.03/44.87)	WAVS..CKRSGKHRAMAVAKLLE.KR.......QAEIEAERC.GESEAL
 1215- 1263 (51.02/32.29)	WGSShtSKSCGKPVSIETASLSEyARyvlrticQQEWVGEHClKEPERL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.13|      28|     700|     942|    1004|       6
---------------------------------------------------------------------------
  323-  352 (50.52/14.81)	PQHRPLVYGLSCMLQTVTlcCPSALVWNYS
  963-  990 (53.62/38.48)	PSNSNLLWDPEFMLDFIE..NPSAHSINYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.20|      47|     738|     761|     816|       8
---------------------------------------------------------------------------
  761-  816 (66.10/86.17)	FGDEgPKARKTKQEAFPtletvfTKLQQL.SYFDQHQVTSQISSN...VLEQITSfaSGT
 1502- 1552 (73.10/61.66)	YQDD.VKARQMMHEALQ......LRLNLVgGMFDTVQRSTQWTTDwalLLLQIIT..SGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.79|      27|     150|    1431|    1467|       9
---------------------------------------------------------------------------
 1431- 1457 (46.21/40.91)	GEELEKGQHLGSSSKKERDRQ.KQKSMS
 1753- 1780 (40.58/16.96)	GELSDQGKLAMDDEKKTKGRKrKSKSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.31|      20|     172|    1298|    1317|      10
---------------------------------------------------------------------------
 1298- 1317 (38.34/25.63)	EGDNPQRQHIKRILQN.....LDQW
 1473- 1497 (29.96/18.30)	KGQDEQREGLLTSLQNqvnqiLSNW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01635 with Med12 domain of Kingdom Metazoa
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