<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01629

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceAAGMDVTGPETDWRSTNFRQKLVSQIDDAMRKAGVAHNKSSKDMESHVFMKAKTREEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQNLTGGPPAGAPGMAMASRAQGAPMSGMSGLGPVGQQMSIPGQQQPPGTSGMAPHGMPGVSTATQPTQLQLQQIAQQQQQQQQQFQQQQVALQQQQFQAQQSAMQQQFHVQQQQAAAAAAAQQQQQQQQQQLQAVQQQQQHMLKLQMQQQQNQQQMQQQQQQLQRIAQMQQLQAAQAMQAQQQQQQQQQQQQQQQIPQQQIQQQPPQQVMQQQMQQMQQQQQQQQQQQQQQQQQVAQAQQSQLPPQSQPQPQPMVSQPQAISGQIPSQICMFTSFFPSILKVRAQLVQQQQQAAAAVQAAQAQAAQMGASGQVPILYSLLLLLILSFSTFQVSQNNITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGPPITAPVASPRKRKYEEDDRQTIPNVLQGEVARLNPKFLVNLDPSHCSNNGTVHLICKLDDKNLPNVPPLQLSVPADYPDQSPLWIKNPRQYAANPFLQSVYRYMTSKLLQLPDKHSVTALLNTWAQSIRQACLSAA
Length785
PositionTail
OrganismCuculus canorus (common cuckoo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Cuculiformes> Cuculidae> Cuculus.
Aromaticity0.04
Grand average of hydropathy-0.751
Instability index85.72
Isoelectric point9.63
Molecular weight87018.68
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01629
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     334.03|      37|      37|     259|     295|       1
---------------------------------------------------------------------------
  126-  170 (48.55/ 7.30)	MSIPG...QQ.QPPGtsgmaphgmpgV.S..TATQ.PTQLQ...LQQI.......AQQQQQQQ
  171-  217 (47.90/ 7.07)	QQFQQQQVAL.Q..Q...........QqF..QAQQsAMQQQfhvQQQQaaaaaaaQQQQQQQQ
  218-  248 (49.52/ 7.64)	QQL..QAVQQ.Q..................qQHML.KLQMQ...QQQN.......QQQMQQQQ
  249-  281 (64.16/12.81)	QQL..QRIAQ.M..Q...........Q.L..QAAQ.AMQAQ...QQQQ.......QQQQQQQQ
  282-  320 (74.52/16.47)	QQIPQQQIQQ.QPPQ...........Q.VmqQQMQ.QMQQQ...QQQQ.......QQQQQQQQ
  418-  458 (49.38/ 7.59)	FQVSQNNITMmSSPS........pvqQ.A..QTPQ.SMPPP...PQPQ.......PSPQPGQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.64|      23|      28|     470|     497|       2
---------------------------------------------------------------------------
  323-  345 (38.44/ 9.19)	VAQAQQSQLP.PQSQPQPQPMVSQ
  470-  493 (40.20/10.87)	PAPSPSSFLPsPSPQPSQSPAAAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.01|      26|      28|     560|     586|       3
---------------------------------------------------------------------------
  530-  546 (20.44/ 8.13)	.............LEKLKQLSKYI.EPLRRM
  547-  577 (36.01/17.19)	INKIDKNEdrkkdLSKMKSLLDILTDPSKRC
  579-  606 (40.57/26.53)	LKTLQKCE...iaLEKLKNDMAVPTPPPPPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      62.34|      12|      37|     101|     112|       4
---------------------------------------------------------------------------
   85-   96 (21.47/10.89)	MNALQNLTGGPP
  101-  112 (22.23/11.58)	GMAMASRAQGAP
  139-  146 (18.64/ 8.34)	GMA....PHGMP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01629 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQNLTGGPPAGAPGMAMASRAQGAPMSGMSGLGPVGQQMSIPGQQQPPGTSGMAPHGMPGVSTATQPTQLQLQQIAQ
2) QNNITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQ
73
422
164
535










Molecular Recognition Features






MoRF SequenceStartStop




NANANA