<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01619

Description Mediator of RNA polymerase II transcription subunit 1 (Fragment)
SequenceETEKLNKMSTLLERLHAKYNQNRPWTETMKLVRQVMEKRVVMNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQSGLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVSCPELVQHLREKNFDEFSKHLRGLVNLYKLPGDNKFKTKMYLALQSLELDLSKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVVLHENNVPRSLGMNVSVTVEGTMTMYKLPIAPLIMGSHPVDSKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQSCTGIPLFDSPPTFVPLYELITQFELSKEADPLPLNHNMHFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDTCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSLSMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSAIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGNKQKKKKSRVPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPIPHPQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPTTNEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNSSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDTDDFKGYASQALTTLGVQVLGAEGGENKFKGSAQSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSGSNMAGPGIDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSTRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSSKSEGSSGSKMSSSLYSSQGGSSSGQSKSSAQSVGKPGSSPITKHGLSSGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTTSSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGEFQGKRDKSDKEKSKVSVSGGSVDSSKKNPDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGESLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSAEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHGMKPESWSKSPISADQSLSMTSSAILSAERPSRASPEFLIGEEDDDLMDVALIGN
Length1574
PositionMiddle
OrganismCuculus canorus (common cuckoo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Cuculiformes> Cuculidae> Cuculus.
Aromaticity0.05
Grand average of hydropathy-0.647
Instability index54.76
Isoelectric point8.85
Molecular weight167344.18
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01619
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1057.43|     185|     185|    1092|    1276|       1
---------------------------------------------------------------------------
  534-  635 (98.53/19.03)	............................................................................PAS...............SP.....GYGM.TTGsnpmSGTttpTNTFPGG.............PITT..LFNM.......S.L..................S...MKERHDSVGHGE.D..................FS...KVSQNPI.....LT.....SLLQIT......GN.....VGSAIGSSP......TPPHHTP....PPVSSPA.............SNTKNHP......................
  636-  824 (149.65/32.66)	..........................MLMNLLK....ENPPQD..FST.LY..........................GS...............SPL...ERQNS.SSG....SPR...MEMGPGGnkqkkkksrvpadKPKH..QTEDdfqrelfS.MdvdsqnpifdvnmtadtlDTPHITPA...PSQCS.TPPTTY.PQPIPH....PQPS...IQRMVRL.....SSSdSIGADVTDI......LSDIAEEASK.LPTT.........NEDCP....PIGTPVR.............DS....SSSGHSQSalfdpdvfqtnSSEN
  829- 1084 (186.10/42.38)	PADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEyfDES.SQSgdtddfkgyasqalttlgvqvLGAEGGenkfkgsaqsdtvdfSII...AAASK.ALG....SSD...IMEHHSG.............GQSP..LLNT.......GdL..................GKEK.SQKRVKEGNGSgSNMAGPgIDGKPGkrsrTPSSdgkSKEKLPKrkkqeTDG.KSPSHSSSTrpftppASTGGSKSP...GSSG......R.SQTPPgvatPPIPKITiqipkgtvtvgkpSSHGQYTSSGSVTS...........SSSK
 1092- 1275 (310.99/75.68)	SSSSSSSSSTSGKIKSSKSEGSSGSKMSSSLYSSQGGSSSGQS..KSS.AQS.....................VGKPGS...............SPI...TKHGL.SSG....SGS...TKMKPQG.............KPSS..LMNP.......S.M..................SKPNISPSHSRPSGGS.DKLASP.MKPVPG....TPPS...SKAKSPI.....SSG.SGGSHMSGT......GSSSSMKSSSGMGSSG......SMSQKPP....PSSNSST.............TSSSSFSSSGSSMS...........SSQ.
 1276- 1416 (148.12/32.25)	.................................NQHGSSKGKS..PSR.NK........................KPSL...............TAVidkLKHGVvTSG...pGGD...DPMDGQM.............GPSS.............N.S..................SSHTMSSKHNM.SGG..E......FQ...G...kRDKS...DKEKSKV.....SV..SGGS....V......DSSKKNPDSKNVGSTGvakiiiSKHDGGS....PSIKAKV.............TLQKPGEGGGESL............RPQM
 1418- 1550 (164.04/36.50)	SSKSYGSPLISG..STPKHERCSPSHSKSPAYTPQNIDSESES..GSSiAEK.....................SYQ..N...............SP..........SSD....DG......IRPLP.............EYSAekHKKH.......K.K..................EKKKVKDKDRDRDRDR.DK.DRD.KKKSHG....MKPE...SWSKSPI.....SAD.......................QSLSMTSSA......ILSAERP.....................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     394.78|     104|     107|     237|     341|       4
---------------------------------------------------------------------------
  217-  322 (151.18/80.19)	.....Y....VSPYDLFedgTGAPVVlheNNVPRSLGMNVSVTVEGTMTMYKLPI.APLIMG.SHPVDSKGTPSFSSITSANSVDLPaCFFLK.FPRPIPVSRAFIQK.LQSCTGIPLF
  323-  422 (154.67/78.84)	DSPPTF....VPLYELI...TQFELSkeaDPLPLNHNMHFYAALPGQQHCYFLNKdAPLPDG..RSL..QGT.LISKIAFQHPGRVP..LILN.LIRH...QVAYNTL.IGSCVKRTVL
  425-  497 (88.94/42.17)	DSPGILqfevCPLSD.....TCFSVS....................................fQHPVNDSLVCVVMDVQDSTHVN...CKLYKgLSDALICTDDFIAKvVQRCMSIP..
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01619 with Med1 domain of Kingdom Metazoa
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