<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01618

Description Mediator of RNA polymerase II transcription subunit 16 (Fragment)
SequenceSPPGRTEPLPCPLRGRAGGMDLAYVCEWEKKPKSNHCPSIPLVCAWSCRNLIAFTTDLRNEEEKDLTHMVHIIDTEHPWDVYSVNSGHTEVITCLEWDQSGSRLLSADADGHIKCWSMTDHLANSWENTVGSVVEGDPVVALSWLHNGVKLALHVEKSGASNFGEKFSRVKFSPSLTLFGGKPMEGWIAVTISGLVTVSLLKPNGQVLTATESLCRLRCRVALADVAFTGGGNIVVATSDGSSTSPVQFYKVCVSVVNEKCKIDTEILPSLFMRCTTDPARKDKYPAITHLKFLARDMSEQVLLCASNQNNSIVECWSLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFFPGLGLALAFHDGSVHIVHRLSLQMMAVFYGSSSQRPADEPTLKRPRTAGPLVHFKAMQLSWTSLALAGVDSHGKLSMLRISPSMGHVLDMNMSLRHLLFLLEYCMVTGYDWWDILLHVQPSMVQNLVEKLHEEYMRQNAALQQVLSTRIVAMKASLCKLSSSTIARVCDYHAKLFLIAISCTLKSLLRPHFLNTPDKSPGDRLTEICSKITDVDIDKVMINLKTEEFVLEMTTLQSLQQLIQWVGDFVLYLLASLPNQGSPVRPGHSFLRDGASLGMFRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWLCCREENHITEPDDALIDECCLLPSQLLIPNIDWLPINDGIISKLQNKQLVRLQFGKAPGLVGHTVSSQFDAFVRAPGQPKIDHLRRLHLGAYPTEECKSCTRCGCVTMLKSPNKVTAVKQWEQRWIKNCLCGGLWRKMPLSYS
Length849
PositionTail
OrganismCorvus brachyrhynchos (American crow)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Corvoidea> Corvidae> Corvus.
Aromaticity0.07
Grand average of hydropathy-0.015
Instability index47.03
Isoelectric point8.22
Molecular weight94565.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01618
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     429.61|     134|     200|       2|     144|       1
---------------------------------------------------------------------------
    2-  144 (219.46/182.11)	PPGR....TEPLpCPLRGRAGGMDLAYVCEWE.KKPKSNHCPSIPLVCAWSCRNLIAFTTDLRNEEEKDLtHMVHIIDTEHPwDVYSVNSgHtevITCLEWDQSGSRLLSADADGH..IKCWSM.TDHL.ANSWENTVGSVVeGD..PVVaLSW
  203-  347 (210.15/140.27)	PNGQvltaTESL.CRLRCRVALADVAFTGGGNiVVATSDGSSTSPVQFYKVCVSVVNEKCKIDTEILPSL.FMRCTTDPARK.DKYPAIT.H...LKFLARDMSEQVLLCASNQNNsiVECWSLrKEGLpVNNIFQQISPVV.GDkqPMI.LKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.45|      25|     190|     448|     490|       2
---------------------------------------------------------------------------
  448-  472 (44.27/22.90)	SLALAGV.DSHGKLSMLRISPSMGHV
  500-  507 (-0.26/27.26)	...............LLHVQPSM...
  546-  571 (36.45/15.32)	SSTIARVcDYHAKLFLIAISCTLKSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.54|      15|     362|     153|     167|       3
---------------------------------------------------------------------------
  153-  167 (26.92/14.33)	LHVEKSGASNFGEKF
  501-  515 (26.62/14.11)	LHVQPSMVQNLVEKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.50|      62|     362|     364|     429|       4
---------------------------------------------------------------------------
  364-  429 (93.54/79.73)	LPKlPISLTNTDLKVAND...TKFFPGLGLALAFHDGSVHIVHRLSLQMMAvFYGSSSQRPADEptLKR
  728-  792 (103.96/71.66)	LPS.QLLIPNIDWLPINDgiiSKLQNKQLVRLQFGKAPGLVGHTVSSQFDA.FVRAPGQPKIDH..LRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.45|      24|      33|     646|     673|       5
---------------------------------------------------------------------------
  646-  673 (36.12/35.05)	PVRPGHSFLRDGASLgMFRelmVVIRIW
  682-  705 (43.33/27.14)	PVYTATSDTQDSMSL.LFR...LLTKLW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01618 with Med16 domain of Kingdom Metazoa
Unable to open file!