<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01606

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceASPGYRLSTLIDFLLHRTYAELTVLADLLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLALQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDETDVSKPLQISHEPPLPACDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKSYNANDNSFIETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMLYGVDQLTLDDIEKSVNDDMKRIIPWLQQLKFWLGQQRCKQSIKHLPTVSSETLQLANYASHPVGNLSKHKLFIKLTRLPQYYIVVEMFDVPGNPTELEYKYHFLSVSYAEGDDSPATALLLQQFKPNIEELVLDTKSGKQMKSGVKRKLSDDPCSVEPKKPKRSGEMCAFNKVLAHVVAMCDTNMPFIGLRMELSNMDIPHQGVQVEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARTLPDIPNHLNVFSEVRIYNYRKLILCYGTTKGSSISIQWNSLLQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQQPFAKQTGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGALHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTVDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPIPDASHSPRAGTSSQAMPTSMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTEALKCRVALNPKTNQTLQLKVTPENTGQWKSEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTTVPQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSPRPG
Length1391
PositionTail
OrganismCuculus canorus (common cuckoo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Cuculiformes> Cuculidae> Cuculus.
Aromaticity0.07
Grand average of hydropathy-0.204
Instability index51.83
Isoelectric point8.84
Molecular weight154755.99
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01606
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     223.40|      36|      39|    1022|    1057|       1
---------------------------------------------------------------------------
  940-  965 (37.61/14.73)	.......P.PSPIG.GDMMDSLISQLQPQQ..PPQ..QP
  966-  997 (46.37/20.01)	QQ.QPFAKQTGASG...AYPLTSPPTSYHNTVTP...SP
 1022- 1057 (64.76/31.09)	SP.ASFGPTPSPSSLGITMGQTANFASPHGTVDPS..SP
 1080- 1098 (26.65/ 8.13)	SP.AARMPGMSPA...................NPSlhSP
 1099- 1135 (48.00/20.99)	IPdASHSPRAGTSSQAMPTSMPPPRKLPQRSWAAS..IP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.85|      56|     121|     615|     735|       2
---------------------------------------------------------------------------
  615-  685 (80.26/147.80)	MELSNM..DIP.HQGVqvegdgFSHaIRLL...KIPPCKGVNEETQKALD.RSLLDcTFRLQ....GRNNRTwvaelvfANC
  737-  803 (77.58/28.65)	LEFARTlpDIPnHLNV......FSE.VRIYnyrKLILCYGTTKGSSISIQwNSLLQ.KFHISlgtvGPNSGC.......SNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     417.61|     106|     120|     148|     255|       4
---------------------------------------------------------------------------
    7-  108 (112.71/64.45)	LS.TLIDFLLHRtyaelTVLAD..LLPRKTDMERKIEIVQFasRTRQLF..................VRLLALV.KW.ANNAGKVEKCAMISSF..LDQ..QAILFV.DtADRLASLardalvHARLPSF
  148-  255 (173.70/108.49)	LH.QLNQILRHR.....LVTTD..LPPQLANLTVANGRVKF..RVEGEFEA.TLTVMGDDPDIPWrlLKLEILVEDK.ETGDGRALVHSMQISF..IHQLVQSRLFA.D.EKPLQDM......YNCLHSF
  264-  379 (131.19/76.21)	LHsQTLMLIRER..wgdLVQVEryHAGKCLSLSVWNQQVLG..RKTGTASVhKVTIKIDETDVSK...PLQISHEPPlPACDSKLMERAMKIDHlsIEKLLIDSVHArS.HQKLQEL......KAILKSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     223.95|      69|     829|     451|     519|       6
---------------------------------------------------------------------------
  451-  519 (121.31/75.86)	QLKFWLGQ.QRCKQSIKHLPTVSSETLQLANYASHPVGNLSKHKLFIKLTR...LPQ..YYIVVE.MFDVPGNPTE
 1282- 1357 (102.64/62.92)	KLELFPDQaSQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQkttVPQeaVSIIVPiIYDMASGTTQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01606 with Med14 domain of Kingdom Metazoa
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