Description | Mediator of RNA polymerase II transcription subunit 21 (Fragment) |
Sequence | LADQFCNAIGVLQQCGPPASFSNIQTAINKDQPVNPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAESLYRLEEENHEAAARLEEVVYRGDVLLEKIQSALADIAQSQLKTRGG |
Length | 121 |
Position | Middle |
Organism | Corvus brachyrhynchos (American crow) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Corvoidea> Corvidae> Corvus. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.198 |
Instability index | 56.19 |
Isoelectric point | 4.36 |
Molecular weight | 13129.51 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | |
GO - Biological Process |
Binary Interactions |
Repeats | >MDP01604 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 45.58| 14| 16| 65| 78| 1 --------------------------------------------------------------------------- 65- 78 (22.32/12.38) EESTAALQAESLYR 83- 96 (23.26/13.13) NHEAAARLEEVVYR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 46.14| 16| 16| 13| 28| 2 --------------------------------------------------------------------------- 9- 27 (23.92/12.98) IgvlQQCGPPASFSNIQTA 28- 46 (22.22/11.68) InkdQPVNPTEEYAQLFAA --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AAARLEEVVYR 2) PTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAESLYRLEEENH | 86 36 | 96 84 |
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