<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01590

Description Mediator of RNA polymerase II transcription subunit 12-like (Fragment)
SequenceQDELTAVNVKQGFSNQPAFSGDEHGSARNIVINTSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHNWFMDLAGSKPLTLLAKKVPILSKKEDIFAYLAKYSVPLLRAAWLIKMTCAYYAAISEAKIKKRQATDPSIEWTQIVTKYLREQLAKVAEFYHGTSSQGNSSVAMPSEVEQALQQWEYNEKLSFYMFQEGMLERHEYLTWILDVLEKIRPADDDLLKLLLPLMLQYSEEFVQSAYLSRRLAYFCARRLSLLLSDGPNLGAAHSPHMILGPSNPPLAVPSPTAPGVSPAQMTCSDFLACPQHRPLVYGLSCMLQTVTLCCPSALVWNYSTNENKNINPGSPLDLLQVAPSSLPMPDGNSAFNQQVRAKIYEVEQQIKQRGHAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQSKDNQEVAPNDEAVVMLLCEWAVSCKRSGKHRAMAVARLLEKRQAEIEAEKCGESEVLDEKESLSSASLTGSSLPVFQNVLLRFLDTQAPSLSDPSSDLEKTEFVNLVLLFSEFTRHDVFSHDAYMCTLISRGDLSTTAAPRPRSPNGAAVGEHYSKDPDVKLEDHGIMEHVSIDSGTAGIFDDVDKSDFKADFSSEFPVFTSEKSAKRDRLRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRMILLYGVGKERDEAKHQLKKITKDILKILNKKSTTEMGGKCSNTAVGSLDEGQKARKNKPEAFPTLETVFTKLQQLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAVQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILSSEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNIQPSNSNLLWDPEFMLDFLENPSAHSINYLMLGRILSDNAANRYSFVCNALMSVCMGHQDPGRINDIGNLCAELTASCTVLSSEWLGVVKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFVAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVCLFPQETEKLFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAILMLGDADIGSNNVGSLKSEEFHVRGFLDELSEEEIWGSSHTLKSCGKAVSIETASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGIKECTEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCMKDPGSGSVAEMNSLLDNIAKATIEVFQQSAELNNNSSNSGIGLFSPHSVGNSDTSNTRQNGKKTFLSSSERQGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVTQVRQAQNHEHPCNWREERYRDDVKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDLHTNNELFTTVLDMLGVLINGTLASDLSNASQGGPEENKRAYMNLVKKLKKELGDKRSESIDKARQLLPLPRLTCDIVACEPMGSLIDTKGNKIAGFDSIDKKQARANGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHTHPKPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKLGELSDQGKHATDDEKKAKGRKQKSKSSSR
Length1782
PositionKinase
OrganismCorvus brachyrhynchos (American crow)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Corvoidea> Corvidae> Corvus.
Aromaticity0.07
Grand average of hydropathy-0.314
Instability index49.97
Isoelectric point6.18
Molecular weight198939.35
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01590
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     556.50|     164|     174|    1289|    1461|       1
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 1105- 1264 (194.89/126.00)	.....................CGDPDaEPGARMTCRLLLHLfrtPQVC.LFPQ........E..................TE.KLF.......PGIRSSCDRHL....L..AAAHNSIEVGAVFAVLkailmlgdaDIGSNNVG.SLKSEefHVRGFLDeLSEEEIWG....SSHTLKSCGKA....VSIETASLSEYAR.YVLRTICQQ....EWVGEHCLKEPERLcTDKDLIL
 1268- 1451 (248.51/185.99)	LSNkqaQKLLQLIcyphgikeCTEGD.NPQRQHIKRILQNL...DQWT.LRQS........W..................LELQLMIKQCMKDPGSGSVAEMNS....LLDNIAKATIEVFQQSAEL.........NNNSSNSGIGLFSP..HSVGNSD.TSNTRQNG....KKTFLSSSERQgvwlVAPLIAKLPTSVQgRVLKAAGEElekgQHLGSSSKKERDRQ.KQKSMSL
 1452- 1598 (113.09/66.99)	LSQ...QPFLSLV......ltCLKGQ.DEQREGLLTSLQN.....QVTqVRQAqnhehpcnWreeryrddvkarqmmheaLQLRLNLVGGMFDTVQRSTQWTTDwallLLQIITSGTVD.LHTNNEL.........FTTVLDM.LGVLIN..GTLA.SD.LSNASQGGpeenKRAYM...........................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     104.84|      19|      27|     851|     869|       2
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  851-  869 (31.43/16.93)	AEL.....LLKSSSLAGSYTTGLC
  881-  898 (32.63/17.86)	ACL.....ILSSEQTAQVF.EGLC
 1025- 1046 (23.36/10.65)	AELtasctVLSSEWLG.V.VKALC
 1048- 1060 (17.41/ 6.04)	...........SSNHVWGFNDLLC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.65|      37|     464|      28|     154|       3
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   80-  137 (54.48/32.48)	AIHNWFMDLAGSK.PLTLLAKKVPILSKKedifaylakysvpllraawliKMTCAYYAA
  282-  319 (65.17/70.75)	AAHSPHMILGPSNpPLAVPSPTAPGVSPA.....................QMTCSDFLA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.73|      33|     464|      28|      62|       4
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   28-   62 (49.65/36.85)	RNIVINTSKIGAyfSSILAEKLKLNTFQDTGKKKP
  501-  533 (54.08/32.88)	RQAEIEAEKCGE..SEVLDEKESLSSASLTGSSLP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.64|      47|     898|     714|     764|      14
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  714-  764 (69.99/57.35)	GKER....DEAKH..QLKKITKDILKILNKKSTTEMGGkcsNTAVG..SLDEGQkARKN
 1609- 1663 (68.65/43.34)	GDKRsesiDKARQllPLPRLTCDIVACEPMGSLIDTKG...NKIAGfdSIDKKQ.ARAN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.10|      29|     318|     236|     266|      15
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  236-  266 (43.63/35.53)	DLLKL.LLPLMLQYSeEFVQSAYLSRRlAYFC
  556-  585 (49.47/30.81)	DLEKTeFVNLVLLFS.EFTRHDVFSHD.AYMC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01590 with Med12 domain of Kingdom Metazoa
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