Description | Mediator of RNA polymerase II transcription subunit 21 |
Sequence | MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDVLLEKIQSALADIAQSQLKTRSGTHSQTLPDS |
Length | 144 |
Position | Middle |
Organism | Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Fukomys. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.233 |
Instability index | 56.97 |
Isoelectric point | 4.29 |
Molecular weight | 15519.08 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | |
GO - Biological Process | blastocyst development GO:0001824 IEA:Ensembl stem cell population maintenance GO:0019827 IEA:Ensembl |
Binary Interactions |
Repeats | >MDP01588 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) LQAASLYKL 2) PTEEYAQLFAALIARTAKDIDVLIDSLP | 85 50 | 93 77 |
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