<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01584

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceRKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLALQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDETDVSKPLQISHEPPLPSCDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKSYNVNDNSFIETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMLYGVDQLTLDDIEKSVNDDMKRIIPWLQQLKFWLGQQRCKQSIKHLPTVSSETLQLANYASHPVGNLSKHKLFIKLTRLPQYYIVVEMFDVPGNPTELEYKYHFLSVSYAEGDDSPATALLLQQFKPNIEELVLDTKSGKQMKSGVKRKLSGDPCSIEPKKPKRSGEMCAFNKVLAHIVAMCDTNMPFIGLRIELSNMDIPHQGVQVEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSSREQGKNHWVDQYLPSPHTAGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPNHLNIFSEVRIYNYRKLILCYGTTKGSSISIQWNSILQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGASSQAMPTSMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTEALKCRVALNPKTNQTLQLKVTPENTGQWKSEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTTVPQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSPRPG
Length1371
PositionTail
OrganismCorvus brachyrhynchos (American crow)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Corvoidea> Corvidae> Corvus.
Aromaticity0.07
Grand average of hydropathy-0.220
Instability index54.31
Isoelectric point8.91
Molecular weight152518.32
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01584
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     329.14|      79|     281|     994|    1080|       1
---------------------------------------------------------------------------
  920-  989 (89.01/26.85)	...............P.PSPIG.GDMMDSLISQLQPQQ..PPQQPQQQPFAKQ.AGasgAYPlTSPPTSyhntvTPSPSM.MHTQSPGN..LH
  994- 1076 (138.48/61.01)	P.SGALRAPSPASFgPtPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAG...NWP.GSPQVS.....GPSPAARMPGMSPANpsLH
 1086- 1153 (101.65/33.27)	PrAGASSQAMPTSM...PPPRKL....PQRSWAASIPTILTHSALNILLLPSPTPG...LVP.GLAGSY.....LCSPLERFLG.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     550.18|     151|     246|     344|     501|       2
---------------------------------------------------------------------------
  215-  341 (103.88/59.40)	......................C.LHSFCLALQLE.vLHS...qTLMLIR......ERWGDLVQVE.RYHAGKCLSLSVWNQQV...LGRKTGTASVHKVTIKIDETdvskpLQISHEPPLPscdsklmeramkIDHLSIEKLLIdsvharS....HQKLQELKAILK.....................................
  344-  501 (245.00/175.07)	NVNDNSFiETALPTLVIPilePC.GRSECLHVFVD..LHSGMF.QLMLYG......VDQLTLDDIE.KSVNDDMKRIIPWLQQLkfWLGQQRCKQSIKHLPTVSSET.....LQLANYASHP............VGNLSKHKLFI......K....LTRLPQYYIVVEmF..DVPGNPTELE.......YKYHFLSVSYAEGDDS
  592-  754 (201.30/125.29)	QVEGDGF.SHAIRLLKIP...PCkGVNEETQKALDrsLLDCTF.R..LQGrnnrtwVAELVFANCPlNSTSSREQGKNHWVDQ...YLPSPHTAGPTRHV......Y.....LTYENQLSEP............VGGRKVVEMFL......NdwnsIARL..YECVLE.FarSLPDIPNHLNifsevriYNYRKLILCYGTTKGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.77|      18|      21|     822|     842|       3
---------------------------------------------------------------------------
  822-  842 (29.04/27.64)	PTVP.MLGLTQRTntaYQCFSI
  844-  862 (30.72/19.73)	PQSPtHIRLAFRN...MYCIDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.07|      34|     238|     537|     574|       4
---------------------------------------------------------------------------
  537-  574 (55.14/52.69)	SGdpCS.IEPKKPKRSGEMcaFNK...VLAHIVAMCDTNMPF
  778-  815 (52.94/35.26)	SG..CSnCHNTILHQLQEM..FNKtpnVVQLLQVLFDTQAPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01584 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGASSQAMPTSMPPPRKLPQRSWA
906
1111










Molecular Recognition Features






MoRF SequenceStartStop




1) ILKRFAEL
1358
1365