<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01582

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDGRKPSVLLKSSDEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMTPHGMTVVSAAAPQTQLQLQQVALQQQQQQQHSSQHRQAALQQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQALQAQPPVQQPPMQQPQPPASQTLPQQLPQMHHPQHHQPPPQAQQPPVAQNQPSQVPPQSQSQPLVSQAQALPGQMLYAQPQLKFVRAPMVVQQPQVQPQVQQQPAVQTAQAAQMVASGVQVSQSGLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPAITAPVLCSRKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length732
PositionTail
OrganismFukomys damarensis (Damaraland mole rat) (Cryptomys damarensis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Fukomys.
Aromaticity0.03
Grand average of hydropathy-0.713
Instability index87.92
Isoelectric point9.43
Molecular weight80441.39
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01582
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.18|      44|      44|     380|     423|       5
---------------------------------------------------------------------------
   95-  132 (44.20/ 7.37)	..RGPGQSLGGmggLG..AMGQP......MPLSGQ...PPPGtSGMTPHGM
  366-  412 (76.64/19.91)	VASGVQVSQSGltmLSSPSPGQQVQTPQSMPPPPQ...PSPQ.PGSQPNSN
  413-  456 (54.33/11.28)	VSSGPAPSPSS..fLPSPSP.QPSQSPVTARTPQNfsvPSPG.PLNTP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.67|      21|      67|     171|     191|       6
---------------------------------------------------------------------------
  173-  193 (41.43/10.09)	QQQQQQQQFQAQQSAMQQQF..Q
  237-  259 (35.25/ 7.29)	QLQQQQQQQQQQQQALQAQPpvQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.91|      23|      23|     503|     525|       8
---------------------------------------------------------------------------
  481-  504 (30.98/19.31)	KQLSKyIEPLRRMINKIDKNEDRK
  505-  527 (37.93/25.43)	KDLSK.MKSLLDILTDPSKRCPLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.08|      18|      22|     626|     643|       9
---------------------------------------------------------------------------
  626-  643 (32.84/19.62)	VARLDPKFLVNLDPSHCS
  651-  668 (32.24/19.12)	ICKLDDKDLPSVPPLELS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      11|      27|     690|     700|      12
---------------------------------------------------------------------------
  690-  700 (23.12/14.77)	NPFLQSVHR.CM
  718-  729 (18.67/10.45)	NTWAQSIHQaCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.52|      16|     108|     347|     362|      14
---------------------------------------------------------------------------
  322-  338 (22.71/ 8.23)	LPGQmLYAQPQLKFVRA
  347-  362 (27.81/12.16)	VQPQ.VQQQPAVQTAQA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01582 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMTPHGMTVVSAAA
2) MDGRKPSVLLKSSDEDAMRKAGVAHSKSSKDMESHVF
3) MLYAQPQLKFVRAPMVVQQPQVQPQVQQQPAVQTAQAAQMVASGVQVSQSGLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
4) QQQQQALQAQPPVQQPPMQQPQPPASQTLPQQLPQMHHPQHHQPPPQAQQPPVAQNQPSQVPPQSQSQPLVSQAQALPG
5) QVALQQQQQQQHSSQHRQAALQQQQQQQQQQQQFQAQ
61
1
326
246
148
139
37
482
324
184










Molecular Recognition Features






MoRF SequenceStartStop




NANANA