<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01575

Description Mediator of RNA polymerase II transcription subunit 1 (Fragment)
SequenceEAEKLNKMSSLLERLHAKYSQNRPWTETMKLVRQVMEKRVVLNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQSGLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVSCPELVQHLREKNFDEFSKHLRGLVNLYKLPGDNKLKTKMYLALQSLELDLQKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVVLHENNVPRSLGMNVSVTVEGTMAMHKLPIAPLIMGSHPVDSKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQSCTGIPLFDTSPTFVPLYELITQFELSKEADPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILSLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSTIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGNKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQALPHAQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPTSTEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNSSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDTDDFKGYAPQALTNLGVQVLGADGGENKFKGSTPSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSGSAMAGAGIDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSKSEGSSGSKMSSSLYSSQGGSGSGQSKGSAQSVGKPGSSPITKHGLSTGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGEFQGKREKSDKEKSKVSVSGGSVDSSKKNSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDGLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSAEKHKKHKKEKKKVKDKDRDRDRERDKDRDKKKSHGMKPESWSKSPISADQSLSMASSAILSAERPSRASPEFLIGEEDDDLMDVALIGN
Length1573
PositionMiddle
OrganismCorvus brachyrhynchos (American crow)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Corvoidea> Corvidae> Corvus.
Aromaticity0.04
Grand average of hydropathy-0.633
Instability index54.87
Isoelectric point8.89
Molecular weight166903.78
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01575
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     995.88|     111|     115|    1111|    1221|       1
---------------------------------------------------------------------------
  534-  634 (65.25/14.45)	............................................................PAS...SP....GYGMTTGsnpmSGTttpTNTFPGGPI...T..TLFNMSIS......M...KERHDSVGHGEDFSkvsqnpiltsllqitgnvgstigSSPT.....PPHHT.........PPPV....S....S.PASNT...KNH
  643-  740 (97.91/25.64)	E..NPPQDF.STLYG...............................................S...SP..LERQNSSSG....SPR...MEMGPGGNK...Q..KKKKSRM.....PAD...KPKHQTEDDFQREL.......................FS.MdvdsqNPIFDvnmtadtldTPHI....TPA.PS.QCSTP...P..
  741-  847 (86.07/21.58)	......TTYPQALPHAQPSIQRMV..........R..............LSS.S.DSIGADVTdilSD..IAEEASKLP....TST...EDCPPIGTPvrdS..SSSGHSQSalfDPDV...FQTNSSEN.........................................PY.........TDPAdliaDAA.VS.PNSDS...SNH
  849-  943 (79.64/19.38)	F..PDGVDFNPDLLNSQSQSGFGE..........EyfdessqsgdtddfKGY.ApQALTNLGV...QV..LGADG.........GE...NKFKGST.P...S..DTVDFS........I...IAAASKALGSSD...............................................................IMEHH...SGG
  951- 1028 (97.40/25.47)	G..DLGKEKSQK..RVKEGNGSGS..........A..............MAG.A.GIDGKPGK...RS..RT..PSSDG....KSK...EKL.PKRK..................KQETdgkSPSHS.................................SSN.....RPF...........TPPA....S..............TGG
 1033- 1104 (83.72/20.78)	G..SSG........RSQTPPGVATppipkitiqiP..............KGT.V..TVGKPSS..........HGQYTS....SGS....................VTSSSS...K........SHH.....SH..................................................SS....SSS.SS.SSSST...SGK
 1111- 1221 (201.38/61.11)	G..SSGSKMSSSLYSSQGGSGSGQ..........S..............KGS.A.QSVGKPGS...SP..ITKHGLSTG....SGS...TKMKPQGKP...S..SLMNPSMS...KPNI...SPSHSRPSGGSDKL.......................ASPM.....KPVPG.........TPPS....SKA.KS.PISSG...SGG
 1259- 1339 (86.97/21.89)	..................................S..............SSS.F.SSSGSSMS...SS..QNQHGSSKG....KSP...SRNK...KP...S....LTAVID...KLKH...GVVTSGP.GGDD...........................PM.....DGQMG...........PS....SNS.SShTMSSKhnmSGG
 1343- 1431 (87.80/22.18)	GkrEKSDKEKSKV.SVSGGSVDSS..........K..............KNSdS.KNVGSTGV...AKiiISKH..DGG....SPS...IKAK...............VTLQ...KPGE...........GGGDGL.......................RPQM.....................AS....SKSyGS.PLISG...STP
 1435- 1531 (109.72/29.69)	R..CSPSHSKSPAYTPQNIDSESE..........S..........................GS...SI..AEKSYQNSP....SSD...DGIRPLPEY...SaeKHKKHKKE...KKKV...KDKDRDRDRERDK........................DRDK.....KKSHG.........MKPE....SWS.KS.PIS........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.13|      12|      77|     309|     321|       3
---------------------------------------------------------------------------
  309-  320 (24.29/15.70)	FIQK.LQSCTGIP
  485-  497 (19.84/ 6.48)	FIAKvVQRCMSIP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01575 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ADVTDILSDIAEEASKLPTSTEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNSSENPYTDPADLIADAAVSPN
2) ALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSGSAMAGAGIDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSKSEGSSGSKMSSSLYSSQGGSGSGQSKGSAQSVGKPGSSPITKHGLSTGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGEFQGKREKSDKEKSKVSVSGGSVDSSKKNSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDGLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSAEKHKKHKKEKKKVKDKDRDRDRERDKDRDKKKSHGMKPESWSKSPISADQSLSMASSAILSAERPSRASPEFLIGEEDDD
3) KNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSTIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGNKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQALPHAQPSIQRMVRLSSSDSI
768
930
530
841
1564
766










Molecular Recognition Features






MoRF SequenceStartStop




1) ASPEFLIGEEDDDLMDVALIGN
2) FGEEYF
3) GIRPLPEYSAEKHKKHKKEKKKVKDKDRDRDR
4) IPKITIQIPKG
5) LSAER
6) MSSSL
7) NKKPSLTAVIDKLKHGVV
8) SIKAKVTLQK
9) VAKIIISKH
10) YGSPLI
1552
868
1475
1049
1544
1117
1288
1393
1379
1421
1573
873
1506
1059
1548
1121
1305
1402
1387
1426