<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01575

Description Mediator of RNA polymerase II transcription subunit 1 (Fragment)
SequenceEAEKLNKMSSLLERLHAKYSQNRPWTETMKLVRQVMEKRVVLNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQSGLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVSCPELVQHLREKNFDEFSKHLRGLVNLYKLPGDNKLKTKMYLALQSLELDLQKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVVLHENNVPRSLGMNVSVTVEGTMAMHKLPIAPLIMGSHPVDSKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQSCTGIPLFDTSPTFVPLYELITQFELSKEADPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILSLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSTIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGNKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQALPHAQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPTSTEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNSSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDTDDFKGYAPQALTNLGVQVLGADGGENKFKGSTPSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSGSAMAGAGIDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSKSEGSSGSKMSSSLYSSQGGSGSGQSKGSAQSVGKPGSSPITKHGLSTGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGEFQGKREKSDKEKSKVSVSGGSVDSSKKNSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDGLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSAEKHKKHKKEKKKVKDKDRDRDRERDKDRDKKKSHGMKPESWSKSPISADQSLSMASSAILSAERPSRASPEFLIGEEDDDLMDVALIGN
Length1573
PositionMiddle
OrganismCorvus brachyrhynchos (American crow)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Corvoidea> Corvidae> Corvus.
Aromaticity0.04
Grand average of hydropathy-0.633
Instability index54.87
Isoelectric point8.89
Molecular weight166903.78
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01575
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     995.88|     111|     115|    1111|    1221|       1
---------------------------------------------------------------------------
  534-  634 (65.25/14.45)	............................................................PAS...SP....GYGMTTGsnpmSGTttpTNTFPGGPI...T..TLFNMSIS......M...KERHDSVGHGEDFSkvsqnpiltsllqitgnvgstigSSPT.....PPHHT.........PPPV....S....S.PASNT...KNH
  643-  740 (97.91/25.64)	E..NPPQDF.STLYG...............................................S...SP..LERQNSSSG....SPR...MEMGPGGNK...Q..KKKKSRM.....PAD...KPKHQTEDDFQREL.......................FS.MdvdsqNPIFDvnmtadtldTPHI....TPA.PS.QCSTP...P..
  741-  847 (86.07/21.58)	......TTYPQALPHAQPSIQRMV..........R..............LSS.S.DSIGADVTdilSD..IAEEASKLP....TST...EDCPPIGTPvrdS..SSSGHSQSalfDPDV...FQTNSSEN.........................................PY.........TDPAdliaDAA.VS.PNSDS...SNH
  849-  943 (79.64/19.38)	F..PDGVDFNPDLLNSQSQSGFGE..........EyfdessqsgdtddfKGY.ApQALTNLGV...QV..LGADG.........GE...NKFKGST.P...S..DTVDFS........I...IAAASKALGSSD...............................................................IMEHH...SGG
  951- 1028 (97.40/25.47)	G..DLGKEKSQK..RVKEGNGSGS..........A..............MAG.A.GIDGKPGK...RS..RT..PSSDG....KSK...EKL.PKRK..................KQETdgkSPSHS.................................SSN.....RPF...........TPPA....S..............TGG
 1033- 1104 (83.72/20.78)	G..SSG........RSQTPPGVATppipkitiqiP..............KGT.V..TVGKPSS..........HGQYTS....SGS....................VTSSSS...K........SHH.....SH..................................................SS....SSS.SS.SSSST...SGK
 1111- 1221 (201.38/61.11)	G..SSGSKMSSSLYSSQGGSGSGQ..........S..............KGS.A.QSVGKPGS...SP..ITKHGLSTG....SGS...TKMKPQGKP...S..SLMNPSMS...KPNI...SPSHSRPSGGSDKL.......................ASPM.....KPVPG.........TPPS....SKA.KS.PISSG...SGG
 1259- 1339 (86.97/21.89)	..................................S..............SSS.F.SSSGSSMS...SS..QNQHGSSKG....KSP...SRNK...KP...S....LTAVID...KLKH...GVVTSGP.GGDD...........................PM.....DGQMG...........PS....SNS.SShTMSSKhnmSGG
 1343- 1431 (87.80/22.18)	GkrEKSDKEKSKV.SVSGGSVDSS..........K..............KNSdS.KNVGSTGV...AKiiISKH..DGG....SPS...IKAK...............VTLQ...KPGE...........GGGDGL.......................RPQM.....................AS....SKSyGS.PLISG...STP
 1435- 1531 (109.72/29.69)	R..CSPSHSKSPAYTPQNIDSESE..........S..........................GS...SI..AEKSYQNSP....SSD...DGIRPLPEY...SaeKHKKHKKE...KKKV...KDKDRDRDRERDK........................DRDK.....KKSHG.........MKPE....SWS.KS.PIS........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.13|      12|      77|     309|     321|       3
---------------------------------------------------------------------------
  309-  320 (24.29/15.70)	FIQK.LQSCTGIP
  485-  497 (19.84/ 6.48)	FIAKvVQRCMSIP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01575 with Med1 domain of Kingdom Metazoa
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