<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01572

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMAAPELGRWGEYGPRLPARLGARAGQEPATALGAVGTMDLAYVCEWERWPKSTHCPSVPLACAWSCRNLIAFTTDLRNDDQDLTRMIHILDTEHPWDVHSINSGHSEAITCLEWDQSGSRLLSADADGQIKCWSMVDHLANSWESRVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFSEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSALPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDPHRKDRFPAITHLKFLARDMSEQVLLCASSQTSSLVECWSLRKEGLPVNNIFQQIAPVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSASARSVDEPAIKRSRATGPAVHFKAMQLSWTSLALVGIDNHGKLSMLRISPSMGHALEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHEEYTRQKAALQQVLSTRILAMKASLCRLSPCTVTRVCDYHTKLFLVAISSTLKSLLRPHFLNTPDKSPGDRLAEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGAPLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDSQDSMSLLFRLLTKLWICCREEGPASEPDEALVDECCLLPSQLLVPTLDWLPISDGLVSRLQPKQPVRLQFGKAPALPGSTPSAQLDGLARLPGQPKIDHLRRLHLGAYPTEECKACARCGCVTMLKSPNKTTEVKQWEQRWTKNCLCGGLWRRAPLSYS
Length865
PositionTail
OrganismFukomys damarensis (Damaraland mole rat) (Cryptomys damarensis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Fukomys.
Aromaticity0.07
Grand average of hydropathy0.015
Instability index48.92
Isoelectric point8.16
Molecular weight95476.71
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01572
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.88|      63|      93|     221|     295|       1
---------------------------------------------------------------------------
  221-  250 (18.63/13.33)	...................................................................SGQVLtstesLCRLRGRVALADI.AFTGGG....N
  251-  345 (81.21/63.80)	IVVATADGSSALPVQFYKVCVSVVSEKCRI..DTEILPSLfmrcttdphrkdrfpaithlkflardmSEQVL.....LCASSQTSSLVECwSLRKEGlpvnN
  365-  404 (44.05/20.55)	ILSATNDLDRVSAVALPKLPISLTNTDLKVasDTQFYPGL..............................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.75|      15|      44|     107|     121|       5
---------------------------------------------------------------------------
  107-  121 (27.60/17.50)	EAITCLEWDQSGSRL
  154-  168 (27.14/17.08)	DPIVALSWLHNGVKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.35|      11|     795|      45|      55|      10
---------------------------------------------------------------------------
   45-   55 (26.34/13.97)	EWE.RWPKSTHC
  842-  853 (22.01/10.57)	QWEqRWTKNCLC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01572 with Med16 domain of Kingdom Metazoa
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