<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01561

Description Mediator of RNA polymerase II transcription subunit 12-like protein (Fragment)
SequenceFSVFQDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGAGDEGLKARKNKQESFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYAMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQAAGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVSSLKNDDFAMRSLRRDGNAEDVWTASQNAKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTDGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMSLFNPNGIGSADTNSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEAASPVSQEPERKSAELSDQGKTAADEEKKTKGRKRKTKSSSRADDYPQSSIYRVPPNYSPISSQMMHHPQSTLWGYNLIGQPQQPGFFLQNQSLTPGSSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAVLFAAQARPAPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGGMVLSPSYSSRVYPAAHSSPALMERLRQIQQQPSGYVQPQASPYLQPLTSSQRLNHQALQQSPLVAGGIDAVLPSAHPNLVVPLPQDPMRPRQPQARQQQRLFQMQQPQQPPQPQQPPLPQQPSQPQNQSLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVAPYGHSSHF
Length1438
PositionKinase
OrganismFukomys damarensis (Damaraland mole rat) (Cryptomys damarensis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Fukomys.
Aromaticity0.06
Grand average of hydropathy-0.438
Instability index61.90
Isoelectric point8.48
Molecular weight160334.81
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01561
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     140.21|      27|      27|    1337|    1363|       1
---------------------------------------------------------------------------
 1229- 1259 (25.91/ 6.60)	TM......................PQGyTMYGTQmPlqQT......SQQQAG.GMVLSPS
 1313- 1361 (44.07/16.38)	QSplvaggidavlpsahpnlvvplPQD.PMRPRQ.P..QA......RQQQRL.FQMQQPQ
 1362- 1391 (41.48/14.98)	QP....................pqPQQ.PPLPQQ.P..SQ......PQNQSLgLQAMQPQ
 1392- 1426 (28.75/ 8.13)	QP....................lfPRQ.GLQQTQ.Q..QQqtaalvRQLQKQ.LSSNQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.67|      24|      27|     762|     785|       2
---------------------------------------------------------------------------
  762-  785 (40.18/26.83)	VLTCLKG...QDE..QREGLLTSLQNQVN
  787-  815 (32.49/20.11)	ILSNWREeryQDDikARQMMHEALQLRLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.74|      22|      27|     401|     426|       3
---------------------------------------------------------------------------
  401-  426 (32.06/27.02)	LLAAACGdaDAEPGARMTCRllLHLF
  433-  454 (42.67/23.10)	FLPQAAG..KPFPGIRSSCD..RHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|      27|     154|     170|       4
---------------------------------------------------------------------------
  154-  170 (22.97/17.75)	LLLKSSSLAGSYtTGLC
  184-  199 (29.21/17.88)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.89|      24|      30|     310|     336|       5
---------------------------------------------------------------------------
  310-  336 (38.86/34.35)	MGHQDA..GRINDIANFSSELtacCTV....LS
  340-  369 (35.04/21.56)	LGVLKAlcCSSNHVWGFNDVL...CTVdvsdLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     127.62|      41|     100|    1162|    1204|       6
---------------------------------------------------------------------------
 1064- 1115 (44.23/15.31)	..RKRKT.KS.SSR..ADDYPQ........................................SSIYrvppnysPISSQmmhhpqSTLWGYNLIGQPQQ
 1118- 1184 (47.07/19.17)	FFLQNQSlTPgSSR..LDPAGS................fvptntkqalsnmlqrrsgammqpPSLH.......AITSQ......QQLIQMKLLQQQQQ
 1206- 1284 (36.32/ 9.29)	VLFAAQA.RP.APQlpQYPGLQqaqtmpqgytmygtqmplqqtsqqqaggmvlspsyssrvyPAAH..........SS......PALME.RLRQIQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.67|      43|     183|     696|     743|       9
---------------------------------------------------------------------------
  696-  742 (65.68/48.69)	SSERRGvwlvAPL.IARLPT.SVQGRVLKAAG.EELEKGQHLG.SSSKKER
  930-  963 (36.27/18.11)	...........PM.GSLIDT...KGN..KIAGfDSIDKKQARGlQVSTKQK
  971- 1002 (38.72/19.56)	EGQKNP....APLsWAWFGTvRVDRKVIK......YEEQHHL.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.23|      13|      29|     536|     562|      10
---------------------------------------------------------------------------
  536-  553 (18.72/12.41)	VLRTICQqewvgEHCLKE
  577-  589 (23.50/15.76)	LLQLICY.....PHGIKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.58|      12|      29|      22|      33|      11
---------------------------------------------------------------------------
   22-   33 (21.74/14.20)	GVGKERDEARHQ
   54-   65 (20.85/13.33)	GAGDEGLKARKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.99|      15|      20|     654|     672|      13
---------------------------------------------------------------------------
  657-  672 (22.85/18.94)	SADLNNNSSNsGMSLF
  679-  693 (27.13/ 9.47)	SADTNSTRQN.GIKTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.19|      21|      27|     467|     488|      16
---------------------------------------------------------------------------
  467-  488 (30.83/25.88)	FAvLKAIMMLGDAK...IGSNNVSS
  494-  517 (30.36/20.01)	FA.MRSLRRDGNAEdvwTASQNAKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.13|      12|      33|    1289|    1300|      17
---------------------------------------------------------------------------
 1289- 1300 (24.12/11.92)	VQPQASPYL.QPL
 1324- 1336 (19.01/ 7.79)	VLPSAHPNLvVPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.07|      21|      26|    1011|    1031|      18
---------------------------------------------------------------------------
 1011- 1031 (37.95/25.56)	PKPRSYYLEPLPLPPEEEEEE
 1040- 1060 (33.12/21.22)	PERKSAELSDQGKTAADEEKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01561 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGFFLQNQSLTPGSSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHA
2) QLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGGMVLSPSYSSR
3) QQRLLRQAQTRPFQQGQPGDQAVLFAAQAR
4) RSYYLEPLPLPPEEEEEEAASPVSQEPERKSAELSDQGKTAADEEKKTKGRKRKTKSSSRADDYPQSSIYRVPPNYSPISSQMMH
5) YPAAHSSPALMERLRQIQQQPSGYVQPQASPYLQPLTSSQRLNHQALQQSPLVAGGIDAVLPSAHPNLVVPLPQDPMRPRQPQARQQQRLFQMQQPQQPPQPQQPPLPQQPSQPQNQSLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVAPYGHSSHF
1116
1217
1184
1014
1265
1166
1263
1213
1098
1438










Molecular Recognition Features






MoRF SequenceStartStop




1) YYLEPLPL
1016
1023