<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01558
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MAASSTAEKEKERLGSNSASVGSNSTRERLLSALEDLEVLSRELIEMLAISRNQKLSQTGEENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSVNMLPPNHSNDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD |
Length | 270 |
Position | Middle |
Organism | Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae>
Fukomys.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.674 |
Instability index | 45.72 |
Isoelectric point | 5.02 |
Molecular weight | 29865.05 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
nucleoplasm GO:0005654 IEA:Ensembl
|
GO - Biological Function | thyroid hormone receptor binding GO:0046966 IEA:Ensembl
transcription coactivator activity GO:0003713 IEA:Ensembl
|
GO - Biological Process | positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
transcription by RNA polymerase II GO:0006366 IEA:Ensembl
|
Interaction
Repeat regions
Repeats |
>MDP01558
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 88.57| 27| 28| 62| 88| 1
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37- 58 (20.11/10.33) ....LEVL..SR..ELIEMLAISRNQklSQ
62- 88 (46.86/32.61) ENQVLELLI.HRDGEFQELMKLALNQ..GK
92- 112 (21.61/11.58) EMQVLEKEVeKRDSDIQQLQK.........
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 64.70| 19| 23| 214| 235| 2
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214- 232 (35.51/28.87) D.VLAPQYPWQSNDMSVNML
239- 258 (29.20/13.23) DfLLEPPGHNKENEDDVEVM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.46| 14| 15| 3| 16| 3
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3- 16 (22.60/15.25) ASSTAEKEKERLGS
19- 32 (22.86/15.51) ASVGSNSTRERLLS
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