<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01554

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMACVRLHAAGGNSPVPGSEGPARAGGLVADVVFVIEGTANLGPYFEELRKHYLLPAIDCPHPVPDPIFPGSEGPARAGGLVADVVFVIEGTANLGPYFEELRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQEIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLETLQPPADVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQQVPLPPAPPSGATLSAAPQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAVSGVGPPFSQATAPTLPPGPPGATKAPPASQPNMVSTVAPGPGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGGQQAPPGLGPILEDQARPSQNLQLQLRPPQPQPQGTVGASGATGQPQPPGTTQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQSGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPAQSWPAQLPPRAPMPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length813
PositionUnknown
OrganismFukomys damarensis (Damaraland mole rat) (Cryptomys damarensis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Fukomys.
Aromaticity0.06
Grand average of hydropathy-0.225
Instability index61.59
Isoelectric point7.26
Molecular weight85226.74
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01554
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     449.79|      45|      50|      14|      58|       1
---------------------------------------------------------------------------
   14-   58 (81.18/28.75)	P...V.PGSEGPARAGGLVADVVFVIE.GTANLGPYFEE........LRKHYLLPAID
   66-  111 (75.81/26.24)	P...IfPGSEGPARAGGLVADVVFVIE.GTANLGPYFEE........LRKHYLLPAIE
  276-  314 (59.18/18.48)	P...A.DVSQDP.RHMVLVRGLVLPVG.GGSAPGP.LQP........KQQVPL....P
  336-  377 (46.34/12.49)	PqyqV.PGNLSAAQVAAQNA.VEAAKN.QKAGLGPRFSP........IN.....PLQQ
  424-  455 (48.54/13.52)	P...T.AQP.GAP..S..MAGTVAP.G.GVS..GPSPAQ........LGAPAL.....
  654-  683 (48.77/13.63)	P...Q.PQPQ..........GTVGASG.ATGQPQP.PGT........TQA....PPGA
  684-  721 (44.49/11.63)	P.....QGPPGAA..............pGPPPPGPILRPqnpganpqLRSLLLNPP.P
  722-  757 (45.48/12.09)	PqsgV.P....PPQAS..LHHLQPP.G.APALLPPPHQS........LGQPQL.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     122.77|      19|      66|     317|     335|       2
---------------------------------------------------------------------------
  317-  335 (38.60/12.91)	P.PSGATLSAAPQQSLP.......PVP
  398-  420 (27.91/ 6.99)	P.P.GAT..KAPPASQPnmvstvaPGP
  764-  778 (29.83/ 8.05)	P.PP....AQSWPAQLP.......PRA
  779-  795 (26.43/ 6.17)	PmPGQMLLSGGPR...G.......PVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.92|      40|      66|     155|     196|       3
---------------------------------------------------------------------------
  155-  196 (65.50/39.80)	SSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFddFKK
  224-  263 (65.42/34.64)	STTYSGYTTESLVQEIGERGIHFSIVSPRKLPALRLL..FEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.99|      44|     107|     496|     541|       4
---------------------------------------------------------------------------
  496-  541 (74.84/40.78)	QVYVNHGEN....................LKTEQwpQKLIMQ..LIP..........QQLLTTLGPLF....RNSRMVQFHF
  551-  614 (32.96/11.17)	GLYRIMGNGfagcvhfphtapcevrvlmlLYSSK..KKIFMG..LIPydqsgfvngiRQVIT...........NHKQVQ...
  616-  651 (32.18/10.28)	....................................QKLEQQrgMGG..........QQAPPGLGPILedqaRPSQNLQLQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01554 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQQVPLPPAPPSGATLSAAPQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAVSGVGPPFSQATAPTLPPGPPGATKAPPASQPNMVSTVAPGPGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGGQQAPPGLGPILEDQARPSQNLQLQLRPPQPQPQGTVGASGATGQPQPPGTTQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQSGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPAQSWPAQLPPRAPMPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
298
610
456
811










Molecular Recognition Features






MoRF SequenceStartStop




NANANA