<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01552

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMAVVLQIRNMVAVLEVISSLERYPITKEALEETRLGKLVNDVRKKTKNEELAKRAKKLLRSWQKLIEPVQQNEAALRGTNGGAHNCRPEAGASVSKGVPDLKHRNDFQRLPGPRLDRLGSRKRRGDQRDLGHPGPPPKVSKACHDLLGPNSSPLPTNGISGSLESFPSPVDGSGLMGSEGSHLEAGENDPLSSKVPVNAVRPHPSSPGLGRPPGPCLQTKVDETSGPPHPRAPSRCSFSPRNSRHEGSFARQRSPYTPKGSVPSPSLRPLVLEATQPEGHQRLAGPGCKAGLPPAEPHLPRAGFSPDSSKADSDAASSGGSDSRKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPLRADSPVHTEQPPRTELDQQEAKANLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMAEYLRQEESTRRGARQPHVLVPHPPPTDLPGLSREVTQGDLDRLEAGQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNVLPYVCLD
Length532
PositionUnknown
OrganismFukomys damarensis (Damaraland mole rat) (Cryptomys damarensis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Fukomys.
Aromaticity0.04
Grand average of hydropathy-0.859
Instability index54.72
Isoelectric point9.33
Molecular weight58176.64
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01552
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.60|      16|      19|     205|     220|       1
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  205-  220 (31.64/13.23)	SSPGLGRPPGPC.LQTK
  225-  241 (21.18/ 6.11)	SGPPHPRAPSRCsFSPR
  256-  270 (21.78/ 6.52)	YTPK.GSVPSPS.LRPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     374.60|      74|     170|     276|     349|       2
---------------------------------------------------------------------------
  125-  202 (86.74/36.07)	...GDQRdLG.HPGpppkvskaCHDLLGPNSS..PLPTNGISGSLESFP..SPVDGSG.lmGSE.GSHL..EAGE.ND.....PLS..SKVPVNAVRP
  276-  349 (127.10/56.20)	QPEGHQR.LA.GPG........CKAGLPPAEP..HLPRAGFSPDSSKAD..SDAASSG...GSD.SRKK..KRYRPRDYT..VNLD..GQVAEAGVKP
  367-  435 (72.00/28.73)	KPLTQKE.....P.........LRADSPVHTE..QPPRTELDQQEAKANlqSPFEQTN...WKElSRNEiiQSYLSRQSS..L.......LSSSGAQ.
  449-  527 (88.76/37.09)	QEESTRR.GArQPH........V...LVPHPPptDLP..GLSREVTQGD..LDRLEAGqwpGVN.GCQD..TQGNWYDWTqcISLDphGDDGRLNVLP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01552 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RQSSLLSSSGAQTPGAHHFMAEYLRQEESTRRGARQPHVLVPHPPPTDLPGLSREVTQGDLDRLEAGQWP
2) VQQNEAALRGTNGGAHNCRPEAGASVSKGVPDLKHRNDFQRLPGPRLDRLGSRKRRGDQRDLGHPGPPPKVSKACHDLLGPNSSPLPTNGISGSLESFPSPVDGSGLMGSEGSHLEAGENDPLSSKVPVNAVRPHPSSPGLGRPPGPCLQTKVDETSGPPHPRAPSRCSFSPRNSRHEGSFARQRSPYTPKGSVPSPSLRPLVLEATQPEGHQRLAGPGCKAGLPPAEPHLPRAGFSPDSSKADSDAASSGGSDSRKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPLRADSPVHTEQPPRTELDQQEAKANLQSPFEQTNW
424
69
493
409










Molecular Recognition Features






MoRF SequenceStartStop




1) RLKERKL
2) SRKKKRYRPRDYTVNLDGQVA
351
323
357
343