<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01545

Description Mediator of RNA polymerase II transcription subunit 12 (Fragment)
SequenceSAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRRPQVNQKDSFWLVTTRSQTAINTWFTDLAGTKPLTLLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSENKVKKRQVVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGSCSSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHIISTQSASTLPNTPAPQPSTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMACEGKGSPSPEKPDVEKEVKFPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTANNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDYKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKELGEHQSDSLEKVRQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEACSTGLQVSTKLKLSPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPTTKTEDYGMGPGRSGPYGVTVPPDLLHHANPSSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTSVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPMSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHMRQQQQQILRFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2118
PositionKinase
OrganismFukomys damarensis (Damaraland mole rat) (Cryptomys damarensis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Fukomys.
Aromaticity0.07
Grand average of hydropathy-0.458
Instability index55.09
Isoelectric point6.65
Molecular weight236374.73
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01545
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     119.62|      15|      15|    2033|    2047|       1
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 2033- 2047 (33.44/15.40)	QQQQQQQQQQQQQQQ
 2049- 2063 (33.44/15.40)	QQQQQQQQQQQQQQQ
 2064- 2078 (26.00/10.40)	QQYHMRQQQQQILRF
 2079- 2093 (26.74/10.90)	QRQGLQQTQQQQQTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     261.28|      44|      44|    1926|    1969|       2
---------------------------------------------------------------------------
 1793- 1823 (39.76/16.09)	....GKKR..SQPTTKTEDYGMGPGRS.GPY....GV.....TVPPD.
 1825- 1856 (35.83/13.76)	..........LHHANPSSISHLSYRQG......SIGLytQNQPLPAGG
 1879- 1910 (54.68/24.97)	PGVLPTT......MT..SVMGLEPS....SYKTSVYR..QQQ..PAVP
 1926- 1969 (84.73/42.83)	QGMLGQSS..VHQMTPSSSYGLQTSQGYTPYVSHVGL..QQHTGPADP
 1971- 2007 (46.28/19.97)	RHLQQRPSgyVHQQAPTYGHGLTSTQRF....SHQTL..QQ..TP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     736.77|     216|     230|     349|     577|       3
---------------------------------------------------------------------------
  218-  440 (271.65/144.02)	...........TIGPLPHDVEV....AIRQWDYNEKLamfmfqD.GMLDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRR.LAYFCTRRLAlQL..DGVSSHSShiISTQSASTlPNTPAPQPSTSSTP...STPfsdLLMCPQ...HRPLVFGLscilqtILLCCP...SALVWH..YSLT.DSR..IKTGSPLDHlPIAPSNLPM..PEGNSAfTQQVRAKLReiEQQIKErGQAVEVRWS
  441-  673 (328.69/154.03)	FDKCQEatAGFTIGRVLHTLEVLDSHSFERSDFSNSL......D.SLCNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKR.QAEIEAERCG.ES..EAADEKGS..IASGSLSA.PSAPIFQDVLLQFL...DTQ.apMLTDPRsesERVEFFNL......VLLFCElirHDVFSHnmYTCTlISRgdLAFGAPGPR.PPSPFDDPAddPERKEA.EGSSSSKLE..DPGLSE.SMDIDPSSS
  676-  813 (136.43/56.17)	FEDMEK..PDFSLFSPTMACEGKGSPSPEKPDVEKEV......KfPPKEKIEGtLG........VLYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRdDARHAIKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ............................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.70|      31|      44|     925|     956|       4
---------------------------------------------------------------------------
  925-  956 (51.59/33.73)	CIVAVLRH.YHACLILnQDQMAQVFEGLCGVVK
  970- 1001 (51.12/29.12)	CILAYLYDlYTSCSHL.KSKFGELFSDFCSKVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.12|      15|      36|    1062|    1078|       5
---------------------------------------------------------------------------
 1062- 1078 (25.85/22.84)	CVGHHDPDRVNDiaILC
 1101- 1115 (30.27/19.60)	CSSNNGTCGFND..LLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     343.89|      80|     149|    1116|    1195|       6
---------------------------------------------------------------------------
 1116- 1195 (134.69/78.71)	NVDVSDLSFHDSLATFVAILIA...RQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKT.PQLNPCQSDGNKP
 1267- 1339 (117.66/67.75)	NISVETASL.DVYAKYVLRSIC...QQEWVGE...RC..LKSLCEDSNDLQDPVLSSAQAQR.LMQLICY.PHRLLDNEDGENP
 1350- 1424 (91.55/50.95)	NLDQWTMR.QSSLELQLMIKQTpnnEMNSLLENIAK.ATIEVFQQSA..ETGSSSGS..TANNMPSSSKTkPVLSSLERSG...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.17|      15|     227|    1630|    1646|       8
---------------------------------------------------------------------------
 1630- 1646 (23.83/18.60)	DSLEKVRqlLPLPK.PTR
 1860- 1875 (27.34/14.69)	DPYRPVR..LPMQKlPTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.87|      11|      30|    1744|    1754|      12
---------------------------------------------------------------------------
 1744- 1754 (21.88/ 8.37)	EPLPLPPEDEE
 1775- 1785 (20.00/ 7.04)	KPGAAPPSTEE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01545 with Med12 domain of Kingdom Metazoa
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