<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01539

Description "Mediator complex, subunit Med24, N-terminal domain-containing protein"
SequenceMPEQDIVIKIFNIVKCAALGKVRNSEFAPIIKNAIENKVLTRKEMHQICGLIIRSLFEEGKYSLKYFKLLESLINLCVISGDIVIGVILKTKFENLDKKNIGNFFLLFRFVDFLVSKKKPPSSKGNDTMKLAEEILSIFNWYVELITWNASESFTNFVVKRLLILLKNRYNCVLLHAVSKKSSECKKLLESRALILENKYPLISTYIRENVLVFKSLLERPYTTGLRLDFEAVSSMITVYATVRTLESARDIAEAIYMISKNLQFTKTKMLYDMFKGILYNLFNNKTTREGNLVFGFAIVKFPQIIKSLLYDLRVLDKMDIVTILGKIVTESKILNIVDFQCKFCFWEILMRELRRQDLINESDMNDAISLRSSEYNKKKDEFDEALLLQPSLNFSLEECINAWESLVKLPFDNLSTVFTGLKNVIKEGGENFNGILMTIWFKEELGNLSRLFSKINYLCQNINDSIDENTKTIRLELFDITLMLLFKLYFHFPDFSIEEFVGLTKEEGENENEENYLFYVWITKIDKSINIPEDPIEVTSDFDWKSIPMTVVDDSPQDVVGQLNQIFTEKENDENKHIRKSVELEDKKVAQDNEEKMESVENVIEEEDIKKNIEEKDEEEIKKETKDDEKMSEGSDIKTDDLKCTEKLDNEEEDIQIRKIVNDLYDDKPFWNEESDFIQVIKLIPKIAFTLCEDLRKKLYEKCNVLDAIWCFRSMPSLVICLVQSLETARNTRARNDVLDAIQLVFKKGKFDDETLYDKWHFVFNILGSKTNDLIKDRGYLPPGADYLISGCRKVLPVLGYKETPNLNLIADAMVYTIKQNFVLPEALYIMDRKINTRGIVLWCDLCFQEISRLETPDELDLATSLLLSISFCRPNECFNQITKHIVDSILNPDTWYIATHQPRRSALARLLVRSMCCMIWVAENKKHKEIYEDQASTIEVDSNMNTLEIVFSRFYKETLSGHLKPTVSFILEFIYEMAVAPQTPELSKLYSFVNRKFIFNLARLDPFSVTIDIYYRIFNFDDNGDNGILQFATLNRFKEIL
Length1043
PositionTail
OrganismStrongyloides ratti (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.10
Grand average of hydropathy-0.173
Instability index41.29
Isoelectric point5.18
Molecular weight121485.11
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01539
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.68|      32|      80|     407|     441|       1
---------------------------------------------------------------------------
  407-  441 (55.18/40.97)	LVKLPF..DNLS.TVFTGLknvIKEGGENFN..GILMTIW
  486-  522 (48.51/28.48)	LFKLYFhfPDFSiEEFVGL...TKEEGENENeeNYLFYVW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.59|      28|      80|     569|     596|       3
---------------------------------------------------------------------------
  569-  596 (47.99/32.36)	TEK..ENDENKHIRKSV.ELEDKKVAQDNEE
  606-  631 (33.47/20.05)	..E..EEDIKKNIEEKD.EEEIKKETKDDEK
  646-  675 (37.13/23.16)	TEKldNEEEDIQIRKIVnDLYDDKPFW.NEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.66|      42|     548|     313|     359|       4
---------------------------------------------------------------------------
  313-  359 (69.27/52.54)	LRVLDKMDIVTilgkiVTESKI..LNIVDFQCKFCF................WEILMRELRRQDL
  831-  854 (22.53/ 7.48)	................IMDRKIntRGIV.LWCDLCF................QEI.....SR...
  855-  909 (58.86/34.75)	LETPDELDLAT........SLL..LSISFCRPNECFnqitkhivdsilnpdtWYIATHQPRRSAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.91|      28|      30|     683|     710|       6
---------------------------------------------------------------------------
  683-  710 (47.31/34.10)	KLIPKIAFTLCEDLR..KKLYEKCNVLDAI
  714-  743 (41.60/29.01)	RSMPSLVICLVQSLEtaRNTRARNDVLDAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.97|      16|      38|     257|     273|      16
---------------------------------------------------------------------------
  257-  273 (25.53/24.08)	YMISKNLQFTKTkMLYD
  297-  312 (28.43/20.89)	FAIVKFPQIIKS.LLYD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01539 with Med24 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KKVAQDNEEKMESVENVIEEEDIKKNIEEKDEEEIKKETKDDEKMSEGSDIKTDDLK
588
644










Molecular Recognition Features






MoRF SequenceStartStop




1) IYYRIF
1015
1020