<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01533

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMETLPRRAATTTIGDLVERACARARDELTALCDAAPGRGEAERASELARWAHRARQRLARVQTLERWAVKSAKIASVAANARAMLTAHEETFARASDGLFHLHQQLEWARAPMWDLPGALEVMCHGNYGFLPLMIGEDGSGPGGGEDGDAREETEDERAAREDVETRFEEEIAERLIRSKAHGCGVRDDHMEWPSEKFKVFSIASGKAAVGVAGEYRATLTLGGPVAPDAIEQPRYGGWRVESIEILAGETDGKFTLNKAEERKLADIACASMVGMLPFGKQPEEGAPPLKPMHLTGLHRIASDAVLMKSANAIVVQAGRLKEIAERGGGDDESRWSRNAIKVEIVKGEAAGVLKGLKVTFWRKSDGGAPGALDVSFNPEKAELLATAKAPGDEDADDVFINHECIDLEALVVNAIRIASSKKLNAIAEELASEKSFKTIMEESSTTDECACRDDEDKWGDDVRPSIRLEISRFTSIFITCRISDGKLMLHGANDLVPSATEAELSKRLALEGHSAISSIVEEVSVAVEQQELKGLLRASGASAHPAPSTMGGDPWAKSDVCPTGTVPTALVPVMPSDGGVFIATWMGATPTFALVRANRINQATRYVVDSIEKLDLGARKGAKPEIVVKLIEEACREKVVDAQRLALMRALKNLRLPFMDVRPTSKGVDLKKAEHVLSFVVANTARWARSKFKRAVRTKSSLKVHVSLRGTDGLSARIGNETCTYEHSEFAVNAVLADVRRIAAAQGFLSALEENDSAIDFSKFGCTLKRQDAYTVALSFKESLMFTIQWRHGGELGPGLYADGDQLTDSVRRALSVAARDGRCEIFACALHAVVAFSALAENLSGDFNLTFAEPNALSLVKFTDEGAMRIYSLGFRLDGSASLIIGRGGDAISDSQSADDDEMHITDDHESLLPACPTGLTVHIEGVASAVEPVVGSKLAHGDYASVPSASVQQVLSALSSAVK
Length966
PositionTail
OrganismOstreococcus tauri
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> Mamiellophyceae> Mamiellales> Bathycoccaceae> Ostreococcus.
Aromaticity0.05
Grand average of hydropathy-0.184
Instability index39.85
Isoelectric point5.47
Molecular weight103984.66
Publications
PubMed=16868079

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01533
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     123.34|      24|      37|     328|     352|       1
---------------------------------------------------------------------------
  143-  174 (24.58/ 6.19)	GGGEDgdareeteDERAAREDVET.RFE.EEIAE
  185-  209 (31.83/10.83)	GVRDD........HMEWPSEKFKVfSIA.SGKAA
  328-  351 (39.75/15.89)	GGGDD........ESRWSRNAIKV.EIV.KGEAA
  367-  391 (27.18/ 6.30)	GGAPG........ALDVSFNPEKA.ELLaTAKAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.87|      58|      71|     672|     742|       2
---------------------------------------------------------------------------
  672-  742 (80.57/74.60)	KKAEHVLSFvvantarwarSKFKRAVRTKSSLKVHVSLRGTDGLSA..RIGNETCTyehSEFAVNAVLAD.VRR
  754-  814 (90.29/54.79)	EENDSAIDF..........SKFGCTLKRQDAYTVALSFKESLMFTIqwRHGGELGP...GLYADGDQLTDsVRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.10|      16|     354|     562|     577|       3
---------------------------------------------------------------------------
  562-  577 (33.01/22.37)	CPTGT......VPTALVPVMPS
  918-  939 (24.09/14.26)	CPTGLtvhiegVASAVEPVVGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.69|      10|     354|     235|     247|       5
---------------------------------------------------------------------------
  235-  247 (13.05/15.34)	RYGgwrVESIEIL
  606-  615 (16.64/ 7.70)	RYV...VDSIEKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.70|      22|     354|     264|     306|       6
---------------------------------------------------------------------------
  121-  142 (43.74/15.24)	EVMCHGNYGFLPL.MIGEDGSGP
  267-  289 (37.96/42.78)	DIACASMVGMLPFgKQPEEGAPP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01533 with Med14 domain of Kingdom Viridiplantae
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