<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01532

Description "Mediator complex, subunit Med14 family-containing protein"
SequenceMNYDGGNDFVPFGVLLKYSCHKISQELIVISELLPKYKDYNRKITITEFSYMARCLLSKILAIVKWLRSYNEHQMCKEIQKFLETQEQFFRETADILCNIARSELVHARVPMYEVNAAVRLSYGKNIKLPFAIKKRFVSDKGVTNTERNKVLSIINKNILSRLSLISSILPPKIESIIIKNGMVTLTVPGEFEVTLTLFNDDISTKWTLLNIKILVEQYDIGYGTKLVHPMQLFTIHQFLQQKMTISKNPVLDLYSYLHDFCTSLQLDVLFCEISQLIGSQYKNKLIVEKYDQDAGILIISFWLTFRKKQYAPSQYKIKLFKDSSKLNNGLRVIQYPLRKNMPTLDLSTGRLSICRLLNETVLIYAREKLFYLKKKLTKLKPYTNVEVTGIKYPKIDFWLFEKSEHSEEECLSIHVNLFTGKFVLNLPFFESKSMLDELTAMINDDVSSKELEIFIRNIKMELLMHRIKKVYTEIKLPLVNKDITLKDIYTLPGDKTILARINKNDCFIVIQLTANKNTNEIIFNFFIYEKRNEVSKKVFSSQYQLVNPVETNMMSDPKHKMFHQTHKLKLFSEECERCLTKRKLWVGDYKSIRDSCYVILYEWQLTEISKAYTDGSTKSSIVKLDTNSVPHLILNCSENVSETDTKSTLSYEKCFMRLDDRWSFQKWGAFTIELFIRNVALKVDFYKKCPARENLAYKYGVKGTNIGIPCNIYWLYPYNFTQKITEILNLEKCKIMNFHKLLEDIAPHYYKFFNQYCSIKYLSNCKVIFAYGQDRRYLLYLNYFGSKVDSYKFYFGQDTSIDLVNGTTSTCKYSSNIMFNAHNNVHVHLLKWKLNKTHLHHLLLYLIKTYKPINILYSIYIPPIYSGVFVSELVYRNYQMKKLPPARLIAIDEYHIRLLFADVVIEFWIGSENNILINDVSNECSKIPGLHSLIHTYSNKLNSYNKPFFEMTRTECSEFFDIRSERFQVNSNTLKKLCLEIEPGNKYGVLIEYLHSQHILNHIKMLTKIYLLEKAEYPTILKFFNMSTSQGSISFNVQYLLLDLETREYNNISTIIYIDTNHFSLRMILNIDTIFQQQESFVNSCQKYFEKVICYNYNNLSFFGFFKLLLTPSQDVLNAIENIFRFELENTKLYNNTTISIQWVRESFNSENNSYALRSFVESNFEEGYVVIPVKISDVVVKEKNGPFDIHVFHLKYYYNTGLMEATDEEEIYPNLNSYLLNYSKEARTTDVDPFLLCLERIITNYIPVLKS
Length1253
PositionTail
OrganismStrongyloides ratti (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.13
Grand average of hydropathy-0.178
Instability index41.04
Isoelectric point8.82
Molecular weight147310.23
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01532
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     608.57|     206|     517|     364|     676|       1
---------------------------------------------------------------------------
   66-  294 (302.32/154.54)	WLRSYNEH..QMCKEIQ......KFLeTQEQFFrETADILCNIarSELVHARVPMYEVNAAVRlsygkNIKLPFAIKKrfvsdkgVTNTERNKVLSIINKNIlsRLSLISSiLP..PKIESIIIKNG.MVTLTVPGEFEVTLTLFNDDISTKWTLLNIKILVEQYDI..GYGTKLV....HPM..QLFTIHQF...LQQKMTISKNPVLDlYSYLHDFCTSLQLDVLFCEISQLI..GSQyKNKLIveKYDQD
  399-  628 (306.25/281.43)	WLFEKSEHseEECLSIHvnlftgKFV.LNLPFF.ESKSMLDEL..TAMINDDVSSKELEIFIR.....NIKMELLMHR.......IKKVYTEIKLPLVNKDI..TLKDIYT.LPgdKTILARINKNDcFIVIQLTANKNTNEIIFNFFIYEKRNEVSKKVFSSQYQLvnPVETNMMsdpkHKMfhQTHKLKLFseeCERCLTKRKLWVGD.YKSIRDSCYVILYEWQLTEISKAYtdGST.KSSIV..KLDTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     228.28|      54|      63|     959|    1015|       2
---------------------------------------------------------------------------
  908-  950 (68.68/33.30)	..FWIGSEN.NILINDVSNECSKI...PG.....LHSLIHTYS...NKLNSYNKPFF
  959- 1012 (91.24/54.20)	EFFDIRSERFQVNSNTLKKLCLEIE..PGNKYGVLIEYLHSQHI.LNHIKMLTKIYL
 1023- 1076 (68.37/35.68)	KFFNMSTSQGSISFN.VQYLLLDLEtrEYNNISTII.YIDTNHFsLRMILNIDTIF.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.71|      12|      63|     714|     725|       4
---------------------------------------------------------------------------
  714-  725 (26.05/14.21)	YWLYPYNFTQKI
  778-  789 (22.67/11.31)	YLLYLNYFGSKV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01532 with Med14 domain of Kingdom Metazoa
Unable to open file!