<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01530

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMALIAALKNDDIKKDGERLRDVSPCISECERLFNIFYKYLTTTSLAHLFNENKDFNNRNQKLTIIECYRLLEHMSDNDQRGLALKFCIENLQMCEEVKSKQYEFEEMLTFIINKLYKNQLLHHFHCFELHVQNTDYKLKIPIDKKKFNFMKENMHLLDYKEKRNIMKSLLVEKLEQIPMHLTEIQRLHVLPIEELILEIIDRENNYIPPLFTITEVFRLTRTSTAYFFPRVSKKLVNMMSSFRPLAEMITPIGRPWLFPIIGHIGFNNSNSTWKLTEGPINKIISKAHLPYTTEYTTMQSYFLYVILKQPRGNASLKTMIPKTNSLGPNNKLNITEILNLFILEGMYECEITNLPTHHPAVQYTWLNLQHLTEFCLFHGNVYFLDLLKLLKKSLIELKYRKAKDELMWLFLQHVTISVGKFQRECMVEIAEIYKILYTGNEAWVGSSLDVMKMIKFFAPAAIWICYEKDNKEEFPKPSFIIKNHMELFKKEAEKGSELHDGMLIVIGNAISTDKINFQEKFFKVLMKQLQGNEDEEKWLLPYGRKVDKRLKAIELTSLDCFTFHAKDMTAKHLMHLLGPSSPPLFTISPAIIESLMRMMLSVEVFDLTKIQFLNLISFYIKNDNLDFTYVIAEAICFRIIDVHIHYSQRLIAIRGVIESLKRLISHDSSNLLYSILEQVFIRSFIWYNQHDMCQLLIKSLTEKLASITSHICSPVSQYTGNIEDSSMLIAPEIVKMLYFTFLKNIKLTGIDVPIEITKTINEYYKFSPTILKFFSTNPDEFVSPIVLETTNNDFLVELVANDPLVKELKYPEEYLSKPKDKYILFCIIFKFLEDNPKADFNGNFYKILAHFNPKELTLSCNTFIEYLNQRFKNIEKDESEKLIKIVNDMIFKYQVTTFDKFLLSLIMHPNDDENMIISLDIIFYLISTCNDLQQNLNFCLTFIPRREFICRADSEKFFKKMVIYHKNFPEYTFKELLQRLEKKEDFIIPEMHLPIFYKNLAELIIPTVDMMLTNGILLNYNFERYVVILKTFSPIYAYHPCPLTFIYEILFLLNCEYIKDPALFQLFTRKIISISESVKSFTVDFYQSDVFYYPSLHATCTELVGKLIEACNIKLIPPKHVARDWRFSEFPPAGQALHSGAIELMFCNYPPHEVAECLLNIAIPKAGENYHEKINAACSLLTALPMKYQDHIFSFMQNAITSKELVCCKDPQLIFTKIEDIIFHCHDIDSIPHLAVIQTFWQLASMTMYDKGIDFFVEVLVDLVTNESQLLYAARIILPFIVKMSEAKEKFKKDETIRCTSALYDMIGNICSNTETQVVYKSVLCDIMYFIKYMFIGDVLKEKAEDVIKKMPNDMQELMKFYNSTGSNTEASRKISTTNISLLSTSNRIFQRIQAPLHFEEISNNHDNAVNSHFDMLNTIQLNRSVNQQVQQGYDNVHIKSDNVENRTSQPQEYKGSQLQQHLLNSSVSFSNSIQGNMLNMNQKSQIDGRGDIGQMSRNDGISDYIMNSQKMPQIGMSSGQGVGCQNPLQSGQNMFSGDPRLQTDIRLQQKQVFQHQFNMHQSLQNKQAMSHLSNINQNTNQPMNPYNNPSQYPNMMHAQHNQGIPPYNQHMSGKQSQMQPPPGMASNFNMPQSMNPYNNPQQFPNMMHHSNIVMHQGVQNPHNISQQGISPIYPQPHMYQGMPNQQQFPPNLQGHGYNQQRM
Length1703
PositionTail
OrganismStrongyloides ratti (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.11
Grand average of hydropathy-0.238
Instability index48.66
Isoelectric point6.67
Molecular weight198424.77
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01530
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     311.58|      49|      49|    1550|    1598|       1
---------------------------------------------------------------------------
 1413- 1456 (40.23/15.58)	.......HFDMLNT.....IQlnrsvNQQVQQGYDNVHIKSD.......NVENR.TSQPQEYKG...
 1461- 1508 (46.12/18.87)	.....QHLLNSSVS.....FS.....N.SIQGNMLNMNQKSQidgrgdiGQMSR.NDGISDY..IMN
 1550- 1598 (96.06/46.81)	QKQVFQHQFNMHQS.....LQ.....NKQAMSHLSNINQNTN.......QPMNP.YNNPSQYPNMMH
 1601- 1649 (77.64/36.50)	HNQGIP.PYNQHMSgkqsqMQ.....PPPGMA..SNFN..MP.......QSMNP.YNNPQQFPNMMH
 1650- 1683 (51.54/21.91)	HSNIV.....MHQG.....VQ.....N....PH..NISQ..........QGISPiYPQPHMYQGM..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     181.83|      44|      44|     623|     666|       2
---------------------------------------------------------------------------
   51-   91 (49.04/29.17)	ENKDFNnrnqkLTIIE..CYRLLEHMSDNDQ....RGLALKFCIENL......
  623-  666 (74.68/48.53)	DNLDFT.....YVIAEAICFRIIDVHIHYSQ....RLIAIRGVIESLKRLISH
  667-  710 (58.11/36.02)	DSSNLL.....YSILEQVFIR...SFIWYNQhdmcQLL.IKSLTEKLASITSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     180.58|      35|      37|     818|     852|       3
---------------------------------------------------------------------------
  770-  827 (36.18/16.57)	IL.KFFST...NPD.EF.....VSPI....VLETTNndflvelvandplvkelkypeeylskPK.D...KYILFCI
  828-  861 (58.83/31.82)	IF.KFLED...NPKADF.....NGNFYK..ILAHFN..........................PK.E....LTLSCN
  862-  906 (24.61/ 8.78)	TFiEYLNQrfkNIEKDE.....SEKLIK..IV...N.................dmifkyqvtTF.D...KFLLSLI
  907-  940 (37.89/17.72)	MH.PNDDE...NMIISL.....DIIFYL..I.STCN..............................dlqQNLNFCL
  941-  975 (23.08/ 7.75)	...TFI......PRREFicradSEKFFKkmVIYHKN............................fP...EYT.FKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.58|      18|      20|    1148|    1165|       4
---------------------------------------------------------------------------
 1131- 1149 (21.61/ 9.91)	PP..AGQALHSGAIELmfcNY
 1150- 1170 (29.08/15.72)	PPHEVAECLLNIAIPKageNY
 1171- 1188 (21.89/10.13)	HEKINAACSLLTALP...mKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.85|      27|      28|     226|     252|       5
---------------------------------------------------------------------------
  226-  252 (48.41/27.93)	YFFPRVSKKLVNMMSSFRPLAE.MITPI
  256-  283 (46.44/26.49)	WLFPIIGHIGFNNSNSTWKLTEgPINKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.66|      28|      28|    1306|    1333|       6
---------------------------------------------------------------------------
 1268- 1315 (27.43/14.13)	SQLLYAARI..ILPFIvKMseakekfkkdetirctsalydMIGNICSNTE
 1316- 1344 (41.70/25.79)	TQVVYKSVLCDIMYFI.KY....................mFIGDVLKEKA
 1345- 1370 (34.53/19.93)	EDVI.KKMPNDMQELM.KF...................ynSTG...SNTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.81|      10|      33|     178|     187|       7
---------------------------------------------------------------------------
  178-  187 (19.30/13.85)	PM.HLTEIQRL
  209-  219 (13.52/ 6.95)	PLfTITEVFRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.34|      19|      33|     494|     514|       8
---------------------------------------------------------------------------
  494-  514 (27.50/27.09)	KGSELHDGMLIVIGNAIstDK
  530-  548 (34.84/26.30)	QGNEDEEKWLLPYGRKV..DK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.97|      10|      20|     135|     144|      11
---------------------------------------------------------------------------
  135-  144 (18.87/13.35)	DYKLKIPIDK
  158-  167 (19.10/13.63)	DYKEKRNIMK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.91|      14|      20|    1192|    1211|      13
---------------------------------------------------------------------------
 1192- 1210 (20.30/17.06)	IFSFMQNAITSkelvcCKD
 1214- 1227 (26.61/11.95)	IFTKIEDIIFH.....CHD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01530 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IQGNMLNMNQKSQIDGRGDIGQMSRNDGISDYIMNSQKMPQIGMSSGQGVGCQNPLQSGQNMFSGDPRLQTDIRLQQKQVFQHQFNMHQSLQNKQAMSHLSNINQNTNQPMNPYNNPSQYPNMMHAQHNQGIPPYNQHMSGKQSQMQPPPGMASNFNMPQSMNPYNNPQQFPNMMHHSNIVMHQGVQNPHNISQQGISPIYPQPHMYQGMPNQQQFPPNLQGHGYNQQRM
2) QQGYDNVHIKSDNVENRTSQPQEYKGSQLQQ
1474
1431
1703
1461










Molecular Recognition Features






MoRF SequenceStartStop




NANANA