<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01529

Description Mediator of RNA polymerase II transcription subunit 31
SequenceMDPTFRHVSGPDYVDSERRRFEAECEFVQALGNPHYCNFLAQKGYFKEEYFINYLKYLQYFKQSEYAKTIVYPHCLFMLDCLQHKEFREAIGNVNNAKYIENQQMLQWQYYYRKRNEYNAKIVQAKEAGELKTTEDVVNLLKELANPEKVKESGDEENIEKSSIEVDQNLLAEDETATQKEIMRLLKEVRDGMKISEDGSILVEEESDDDGSEELTSEIKELLEEIERETNDSLQKAFSEEEDAEIEEYDQDLKQAPYSQNEDYETYTREQEVKRIEAAFDQVAEYGELTEEELTKNGYPIDVLYDSNIISLAIRSKDSCANDQKSRKYY
Length330
PositionMiddle
OrganismStrongyloides ratti (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.11
Grand average of hydropathy-0.943
Instability index64.26
Isoelectric point4.48
Molecular weight38856.35
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01529
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.26|      18|      18|     226|     243|       1
---------------------------------------------------------------------------
  226-  243 (29.89/15.68)	IERETNDSLQKAFSEEED
  246-  263 (30.37/16.04)	IEEYDQDLKQAPYSQNED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.30|      20|      20|      36|      55|       2
---------------------------------------------------------------------------
   21-   45 (27.74/16.31)	FEAECeFVQALgnphYCNFLAQKGY
   46-   66 (33.56/21.18)	FKEEY.FINYL...kYLQYFKQSEY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.70|      18|      22|     264|     281|       3
---------------------------------------------------------------------------
  264-  281 (30.69/19.24)	YETYTREQEVKR...IEAAFD
  286-  306 (25.01/14.39)	YGELTEEELTKNgypIDVLYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.37|      25|      42|     130|     154|       4
---------------------------------------------------------------------------
  126-  150 (40.38/30.98)	KEAG....................ELKTTEDVVNLLKELANPEKV
  151-  195 (29.99/21.21)	KESGdeeniekssievdqnllaedETATQKEIMRLLKEVRDGMKI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01529 with Med31 domain of Kingdom Metazoa
Unable to open file!