<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01527

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMNDPKKVDEYDSKFVKPIGIPNKNKKYVYVEPRREWSVMEYSLEGAEALIPPKTFQESLAEKASRIDWKKIVGSNVTYDDPEVVFDTESDKALDLVDRILALKIHQKSYKPPQHYFNNTSKLVVKPDDLQINKSNTLNNENKERERFNKLLKEANEAGLKFPTDDLDYDELSKHVDINAMDSSEGPVVITDMEQVVENNITYESFKNQKYIEGETGIDKKKKKEKESDDEDIGYMMGKAAVESFRQGRIKQELEHHGMPSIKRVVSDPQISSKIRYFVQKRLQKKVLEYNFIGMPLQNEEPRTIFQILRPSSNNTFGILPQELSNEIFDPTKCDEFVKELTDRQVDAARKAWDALELQTNEFDVFSQLRNDTLEAKNRGEDVKTVSINFGSSRIVIPVIVKDSFSSEPRKSDEMSSDSEDEDFQMDVDKEIEEEEHIEPTSTVAFYINRSGKLLGCKIDGESYSLDKPEFLGNELTKKMLEAIENNGINKKGDEVASDDESTSSRGRNKHKDTDVPSRAPSPIIPEAGPWHKVAKYLHEALQHINYLHDQLRVMDTPYMKPLTVAESIGDENTAINSKLYLWVAKRKALEESVAVLETGTKHRKVDTESFEDKQAFFNELKSMREFWRLRKVGRFLTGDLGYRIFGSKFIPSESFDVTRKSSAMLEEERKYKAEICDTSPLSYLQVIVPCDLMRRTVMSVDIIIDHNTGIEEPSSRRKDNSDLEYMVVKPEDAMKIHWRKALLWAQESLICRDIFKNLFSDAAQATEIFSTQRENVLMVSLFSNVVLKIQLDFYPFKDGDLPQPGIPVLNTLLRHLFLSDLCIRPKLLQQFITLPLIDSQDYIAGRTFSDASKSEMKEMINFTRHTTLLSRLCKVASHYKLVQEVINELENFSIKHPDPSLSWRFYRITSIESFINVVLSNRGFVDIIPKQLFTISITHNNILINIRAKEGKDLFECGHNLEIFVKSLKMVYCRYMINSVAIQSKQWVWYVLSSNLRFSESHYTTNCDLTLYMSNVSGLYHIYFFVNYITLEKSITVERSIDLVLQRNGNSSFDKNIDDEKYVTLEYNALVGDSLLKKFDFLFAILR
Length1087
PositionHead
OrganismStrongyloides ratti (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.09
Grand average of hydropathy-0.509
Instability index46.96
Isoelectric point5.59
Molecular weight125550.25
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01527
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     594.66|     221|     625|      94|     340|       1
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   18-  291 (322.71/211.95)	IGIPNKNKkyvyvEPRREWSVMEYSLEGA..........EALIPPK..TFQESLaekasridwkkivgsnvtyddpevvfdtesdkalDLVDRILALKIHQKSYKPPQHYFnNTSKLVVK...PDDL..QINKSNTLNNENKERERFNKLLKEANEAGLKFPTDDLD.YDELSKHVDINAMDsseGPVVITDMEQVVENNITYESFKNQKYIEG..ETGIDKKKKKEKESDDEdIGYM........MGKAAVESFRQGRIKQELEHHgmpSIKRvvSDPQIS......SKIRYFVQKRLQKKvleyNF
  292-  500 (199.98/127.40)	IGMPLQNE.....EPRTIFQILRPSSNNTfgilpqelsnEIFDPTKcdEFVKEL........tdrqvdaarkawdalelqtnefdvfsQLRNDTLEAKNRGEDVKTVSINF.GSSRIVIPvivKDSFssEPRKSDEMSSDSEDEDFQMDVDKEIEEEEHIEPTSTVAfYINRSGKLLGCKID...GESYSLDKPEFLGNELT......KKMLEAieNNGIN.KKGDEVASDDE...........................................................................
  825-  924 (71.98/30.56)	.................................................................................................................................................................................................PKLLQQFITLPLIDSQDYIAG..RTFSDASKSEMKEM....INFTrhttllsrLCKVASHYKLVQEVINELENF...SIKH..PDPSLSwrfyriTSIESFINVVLSNR....GF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.31|      14|      32|    1028|    1041|       2
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 1028- 1041 (23.24/17.50)	YITLEKSITVERSI
 1062- 1075 (24.07/18.42)	YVTLEYNALVGDSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.66|      30|      32|     943|     973|       3
---------------------------------------------------------------------------
  943-  973 (48.64/37.01)	LINIRAKEGKD..LFECGHNLEiFVKSLKMVYC
  976- 1007 (49.03/32.44)	MINSVAIQSKQwvWYVLSSNLR.FSESHYTTNC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01527 with Med17 domain of Kingdom Metazoa
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