<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01522

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMASLEDEDWPSQKFRDHVIQRLEPELQRNRQHAPNLPVPGNAREVEDYVFQKCTSKDEYMRTIAKVINAINCNSKSSSMPSVLSNHYNKNDPQPTQQSDIPLSVVGSGNVSSNTEISSRQLNQVSSSGIPIHRQSPLPSNNNITSNTPPVSGIIQQQTSSSSGFANSQKINSSTGYNSQISQNTNQPQFMRLSQQIKNEYNSINDQVNYGIPQVNSMYPQTINKPSIPTEDMMSGNPMIQRQRAWNVQQDNGQYMQNSMIQMPQPNMGMGQPMMQYINQQPPYTDYSYQNSGIPLNNSLNFNSNCLPIQNEKTYDNKLKELRQHANMIKGKANYYRSSGNPTAASRLDYVYEVLIGEKKPPYETILKIEEEINKILLSQNIMVNNIGMSSQMGGTIMQEPKLLQQQYYSQPQWMGPQQLQPLSSGPSPYSVTGTNPMSHQQYNVPNSPSGSQQQQQQSLRHSPYQIPNKHNTGNYTSRQSSLPHGKSQSQPTNINTYQNNFHYPTQSLTTTPITNNSSTLEELYSTSYDQMLGSKGIDDINNLYGQQQSQNNTPNFTTYLTSSMTQEINALNSQFTFKNICGTYDGNYINVDVIFNNFEKDFPPFRLVIPKTYPGVPVSFEQLPLDIESFLYEEVQSHMYSEIRKKNPKTITDILKIAESAALDFYSKQQCNQMNTPVLDDLFRSSQYDSALQ
Length693
PositionTail
OrganismStrongyloides ratti (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.08
Grand average of hydropathy-0.853
Instability index62.43
Isoelectric point6.16
Molecular weight78494.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01522
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     605.52|      89|      92|     123|     213|       1
---------------------------------------------------------------------------
   19-  104 (59.64/15.27)	.......IQRLEPeLQRNR..QHAPN..LPvPgnareVEDYVF.............QKCTSKDEYMrtiakviNAINCN.........SkSSS.........M.PS..VLSNhyNKNDPQPTQ..................QSDIPLSV
  125-  213 (149.55/51.23)	SSSGI.PIHRQSP.LPSNN..NITSN..TP.P.....VSGIIQ.............QQTSSSSGFA.......NSQKIN.........S.STG.........Y.NS..QISQ..NTNQPQFMRLSQQIKNEYNSI....NDQVNYGIPQ
  215-  289 (100.60/29.40)	NSM.Y.PQTINKPsIPTED..MMSGN...P..........MIQ.............RQRAWNVQQD.......NGQYMQ.........N.SMI.........Q.MP..QPNM..GMGQPMMQYINQQ..PPYTDY....SYQ.......
  290-  386 (60.73/15.69)	.NSGI.......P.L..NNslNFNSN..CL.P.........IQnektydnklkelrQHANMIKGKA.......NYYR.............SSGnptaasrldY.VY..EVLI..GEKKPPYETI.LKIEEEINKIllsqNIMVN.NI..
  390-  468 (96.11/27.69)	SQMGG.TIMQEPK.L..........................LQ.............QQYYSQPQWM.......GPQQLQplssgpspyS.VTG.........T.NP..MSHQ..QYNVPNSPSGSQQ..QQQQSL....R.HSPYQIPN
  470-  531 (52.09/12.39)	.............................H.N.....TGNYTS.............RQSSLPHGKS.......QSQPTN.........I.NTY.........Q.NNfhYPTQ..SLTTTPITNNSSTLEELYSTS....YDQM......
  533-  617 (86.80/24.13)	GSKGIdDINNLYG.QQQSQ..NNTPNftTY.L.....TSSMTQ.............EINALNSQFT.......FKNICG.........T.YDG........nYiNV..DVIF..NNFEKDFPPFRLVIPKTYP............GVP.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01522 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MASLEDEDWPSQKFRDHVIQRLEPELQRNRQHAPNLPVPGNAREVEDYVFQ
2) NYGIPQVNSMYPQTINKPSIPTEDMMSGNPMIQRQRAWNVQQDNGQYMQNSMIQMPQPNMGMGQPMMQY
3) SSMPSVLSNHYNKNDPQPTQQSDIPLSVVGSGNVSSNTEISSRQLNQVSSSGIPIHRQSPLPSNNNITSNTPPVSGIIQQQTSSSSGFANSQKINSSTGYNSQISQNTNQPQFMRLSQQIK
4) WMGPQQLQPLSSGPSPYSVTGTNPMSHQQYNVPNSPSGSQQQQQQSLRHSPYQIPNKHNTGNYTSRQSSLPHGKSQSQPTNINTYQNNFHYPTQSLTTTPITNNSSTLEE
1
208
77
413
51
276
197
522










Molecular Recognition Features






MoRF SequenceStartStop




NANANA