Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNIEQTLKKDLVKDILELDKKMSSLFENVFKKKDEVEENNKEDFKCLVNDISRIEIEIIKKLKNAPCIEKTQKKIKKMKAEIFKYDKAILKTEAGLVRIYGSVTNSLNIAQKKLCELKKSQQQHNTKSDILEMSKNLTKSYTISAPSFYKTGDYVKPFPTGVQFVRGCLKHSIPIKDISKKSGIKNPTINMFHNVKSIQQHDRSILSSSNQQRQMAFLQQANHNYPNSNLKHINRINQFAPNQRHYNIQQQNSYKNLLQRSLIPQHHHSQIPNRVSKLNFQYDQNRFPNDSHLGTKRFFTKPGQSDVQQTNLMRRTQSATNLQMKPQRLPQYSSYLQRIEDGTTFKKAKKLRVGKNMRILPWSSFIDPYYKGYETSASDDSDELSSEEEREITNKYYTRKAGPSVELPVERTDSPETSRHMNYL |
Length | 424 |
Position | Middle |
Organism | Strongyloides ratti (Parasitic roundworm) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.936 |
Instability index | 55.27 |
Isoelectric point | 9.72 |
Molecular weight | 49475.86 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP01521 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 129.04| 31| 52| 171| 202| 1 --------------------------------------------------------------------------- 139- 168 (25.36/12.61) KSYTISAPSfYKTGdyVKPfPTGVQF..VRGC.... 171- 202 (51.52/38.40) HSIPIKDIS.KKSG..IKN.PTINMFHnVKSIQQHD 223- 252 (52.16/33.88) HNYPNSNLK.HINR..INQ.FAPNQRH..YNIQQQN --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 62.34| 19| 22| 301| 322| 5 --------------------------------------------------------------------------- 301- 320 (28.25/21.83) KPgQSDVQQTNLMRRTQSAT 325- 343 (34.09/15.24) KP.QRLPQYSSYLQRIEDGT --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) MRILPWSSFIDPYYKGYET 2) REITNKYYTRKA | 357 390 | 375 401 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab