<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01518

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMTNSTKSYKISHWKSENYESRGMRKNSTNRSFDIFYQDAMQDEDNISSLERITSGYVSNSLPYEYDSYIFNQRNKISDDFVDKTIKKAYSFFDNLINKQCADSSKFHRKIPLPKVFQISEWNYKIPKNPNINEFFENLTKGKDFYSLIKKFPSFNSKENYLDYLYEYNVPILKAIWFIKIVAVLKATKVDDGKAPKKSQAQQIALEYVQCIISGYIIYTFKYLSTNGVYNEKKIEKWNYFALLIKHMFEEGVLDRQDFLIDIIDLLNIYVDFELEDPTKFRILFLFISQFSTFITQNIIIARRLAFVICKRLRKYHLDYMNFIGQPITCPEVMSKLMKCEKHRPIISAMISMFYSIMTECIQAITVKYITIDKKFTGITCYKDLTDTPLEYLTCRIDDMCKEANLLPLNMIEIMKKKIEEFKKRSIDIRYTLHNTISQDNYCSEVSWMILKIFSILDNIYLVNQNNMIKIYKSIFVLETGIDKEIEKLIKLRMIIHWCITSQRSGTYRVTIVVKLLSIHLSDMKNRVKKMITILNDYLNTEGPRLGYCNFGYEFRNIILLLNDLQSYGILRYKDLLDNWILSGKININECIWGRTLKYVYGENYERDLHPSWNRHIEMSSRYALLFYRRDSEKHFLINIENITMEERIFLQMPILPSIENKDVILYRDNIIYGISISRKEHLNYLKEVARGIIKVWKKLYYFKIKIDNEKSYFHEYHDIKRYQECGDILKNFRKQTYYDQTLITYWVANDFKSYITGFIKNTTNILPGSDGLDYIMRMFCISMNIGGMIEYIVNLLEEIGKLEDVMISRGYNLISGMITKSYAFTVTGYLSEHTNYFLFHPNAVDVLNGLFRTIENTVILENYPRTGYDTTIGMFIYYCKNVLVKEGITSYDNILGCDKHFSKLYPKPFIEIKIDVPKIKAKKLFFGKYLKTSPQGMLFSEFKYTMKKINKGGFPLRIAFILSALQTVKGLGRDINKISMLANYVSNVSVQLKMENEWISVILEMCSLTTNPNSLYKGIHRTINIGRTTTHYPISSFITILGGKYVFRPSDLIENLIKTTLISVFKGNYLRSKYGYEKVVLGGLICTKLLTGYHDPFKLPKGYSGISEVKRPVVHRLADFKACSVLFNHEYNNVIFKFIQLLSLANRPIRKIKTKKPSKRIRINHFFKACLLCLSEQPWFYQYMKFSVLQLDLNLLKNDNNLFKNYKITGTLLNFISREKGDRLNKLKILSSAEKLSKKNFIELNLESLNIWNFRSVLWSLFGMVNDIMRKPTKLNYAQKVFNCNQMITDIAKGIKSIFTKNSYSYGKNVIFKTDIFFRLNDISNLWLVEYLINEFPKINGLKCDLKFNKMSLTPLSRSVFIELSSLITESYSINEYGRKTEQISHLFHLPPFSKLIQTLANVEPLCSHGLLQGVYSYLTNIVKEFNSKRILCPQLLKDKDGIILRVLLVCGMMDQLLTMPTVEPWAYLLWQLLYLEIIHKEREEKYYYICYEALSTILFISTFKIHQRHNEKLHYKARYKAYSHFCKKIRRECQDRPFPINKLELSQLLPLPKRTFDYIIFDYYYNYVGKIQNVSKIDGSNGSMVNSINQTGFYPVDKIKLTTFEIIPSFFHENLGRRAVNYTFYQAQLVDYNPRLERNTIIRLLFHKHNHLFPKVSIYGDCKILKNSFFYKPPAIEYNVEEKKETDSPLQELINMTSKSKSPIQLSSKKQVESNEVKKSEDKVNLISSKELQIKDGNNENPSNSHNKNLNYVNEPQTSRDFNLTQQAFNGRDLSTSQNGVMNPSVSMAQPNLPQHANHNHLISQPIKNNTYSYQSSNSFYTSESQKALKRSLDPSPTISVKKRKDNTENIPISSIINQQNNPNNINTNNILPRPITNVYIQPPEQRNMVTSQQSEIPQQNTSQQTNQMRMTMNQQPLIPPNIENFSKQPQQHIPQHTKTIMNPQMRGNGIESGAMHQNIQQGRQNLGLQNFINPQQKIPHPGDRQNLRGGFENTNIMSKDMIHQKNNFNQNIQHQQQYNVPMNNQHLNQGPMMDQYQINLRKEMIYRNNQQQNQLQFHDPNMARLYNQGNPQQQQPINRNQMYPR
Length2087
PositionKinase
OrganismStrongyloides ratti (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.12
Grand average of hydropathy-0.406
Instability index42.26
Isoelectric point9.38
Molecular weight245048.62
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01518
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     245.82|      40|      40|    1974|    2013|       1
---------------------------------------------------------------------------
 1777- 1814 (51.55/26.92)	TSQNGV.MNPSVSMAQPNLPQH........................A.....NHNH.LIS.QP..IK...N..NTYS
 1850- 1913 (27.51/10.54)	.ENIPI.SS..IINQQNNPN.NintnnilprpitnvyiqppeqrnmV.....TSQQsEIP.QQNTSQqtnQ..MRMT
 1914- 1950 (32.55/13.97)	MNQQPL.IPPNI...................................enfskQPQQ.HIPqHTKTIM...NpqMRGN
 1951- 1992 (44.45/22.08)	....GI.ESGAM.HQ..NIQQG...............rqnlglqnfI.....NPQQ.KIP.HPGDRQ...N..LRGG
 1993- 2032 (65.34/36.32)	FENTNI.MSKDMIHQKNNFNQN........................I.....QHQQ.QYN.VPMNNQ...H..LNQG
 2035- 2078 (24.43/ 8.44)	MDQYQInLRKEMIY.RNNQQQN.........qlqfhdpnmarlynqG.....NPQQ.QQP.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     194.83|      40|      40|     363|     402|       2
---------------------------------------------------------------------------
  298-  332 (34.64/20.14)	.....IIIARRLAFVIC.KRLRKYHLDYM...NF.....igqpitCPEV
  333-  363 (47.11/30.70)	MS.KLMKCEKHRPII........SAMISM...FYSIMTE......CIQA
  364-  403 (66.45/47.06)	ITVKYITIDKKFTGITCYKDLTDTPLEYL...TCRIDDM......CKEA
  406-  444 (46.64/30.30)	LPLNMIEIMKK..KIEEFKK.RSIDIRYTlhnTISQDNY......CSE.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     549.23|     117|     118|    1135|    1251|       3
---------------------------------------------------------------------------
 1127- 1223 (144.45/88.04)	....................FN...HEYNNV......IFKFI..QLLSLANRPIRK.IKTKKPSKRIRINHFFKACLLCLSE.....QPWF....YQYMKFSVLQLDLNLLKN..D.NNL.FK.NYKITGTLLN.F..ISREKGD.R
 1224- 1347 (115.69/68.73)	LNKLKILSSAEKLSKKNFIELN...LESLNI.....wNFRSVlwSLFGMVNDIMR......KPTKLNYAQKVFN.CNQMITDiakgiKSIFtknsYSYGKNVIFKTDIFFRLN..DiSNLwLV.EY.....LINeFpkINGLKCDlK
 1348- 1465 (137.96/83.68)	FNKM....SLTPLSRSVFIELSsliTESYSIneygrkTEQIS..HLFHLP..PFSKlIQTLANVEPLCSHGLLQGVYSYLTN.....IVKE....FNSKRILCPQL...LKDK..D.GII.LR.VLLVCGMMDQ.L..LTMPTVE.P
 1470- 1580 (151.13/92.53)	LWQLLYLEIIHKEREEKYYYIC...YEALST......IL.FI..STFKIHQRHNEK.LHYK..ARYKAYSHFCKKIRRECQD.....RPFP....INKLELS..QL.LPLPKRtfD.YII.FDyYYNYVGKIQN....VSKIDG...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.42|      23|      36|     827|     850|       4
---------------------------------------------------------------------------
  827-  850 (38.05/28.61)	TGYlSEHTNYFLFHPNAVDVLNGL
  866-  888 (42.37/27.25)	TGY.DTTIGMFIYYCKNVLVKEGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.59|      25|      71|     575|     609|       5
---------------------------------------------------------------------------
  533-  558 (42.92/21.33)	ILNDYLNTE....GPRLGYCnFGYEF.RNII
  580-  609 (34.68/26.07)	ILSGKININeciwGRTLKYV.YGENYeRDLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     191.39|      46|      72|     942|     990|       6
---------------------------------------------------------------------------
  942-  988 (70.61/49.78)	FKYTMKKINKGGFPLRIAF.....ILSALQTVKGLGRDINKIS.MLANYvSNV
 1016- 1055 (53.56/25.83)	YKGIHRTINIGRTTTH..Y.....PISSFITILG.GKYVFRPSdLIEN.....
 1057- 1106 (67.21/42.12)	IKTTLISVFKGNY.LRSKYgyekvVLGGLICTKLLTGYHDPFK.LPKGY.SGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.31|      20|      45|    1622|    1641|       8
---------------------------------------------------------------------------
 1622- 1641 (36.43/22.94)	NYTFYQAQLVDYNPRLERNT
 1668- 1687 (35.88/22.47)	NSFFYKPPAIEYNVEEKKET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.45|      18|     223|     460|     484|       9
---------------------------------------------------------------------------
  467-  484 (30.32/28.88)	MIKIYKSIFVLETGIDKE
  692-  709 (32.13/13.13)	IIKVWKKLYYFKIKIDNE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01518 with Med12 domain of Kingdom Metazoa
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