<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01517

Description "Mediator complex, subunit Med14 family-containing protein"
SequenceMSENSNSDDNGYDKKDESFEITIPEFPGDNDECFSFSDNDNIRVKAKLEKGEKLPNLPPVAEQHAPGTMPLAVLLQYVCQKINQELLSMTELVCKTSDIGRKVALVQFAYTAKNLLSKVLAVVKWFRYFKRYRLCIPIQNFLDQQLQQYRDTADALCGIARGELTYARMPQYNIDSAIDVICGVYARLPLSIKKRFIPEPDLTTQELANILTRINLAIKTRLSFVAHFLPTRIKNIITNNGTVTLVVPGEFEITLTLPGETLNVKWKLLRVRILIHDYEFGDGKELVHYLQLKKIHKFCQKLLDRSKKPLISVYNFLHDFCITLQFDLIFGEILELTQGIYKNKVFIDFCNVQRRYISLAYWVNKKTKKNQSPNYQIVFSIPKKSRNSGIVVEYRPSDSFPIESYKEFEEKPSVHNILKSVIEYNVYKKLILLKEQLEKCNPKLNVRLTGDLLPKVTFYLLNKNIDGDDDELSFGVNFFTGEYMYVGDELKESLLLKATIFGLNNNIDTKKLEKCLDGIRTEFIMKKYIKSVNMLNVKLVMEKTLPSIFRKYAYFEHSIKLYFQIIKEPQCYITITFTDPKKKGLCINFFLLSTNEGKSTIIKLNPFDFYNPSKINTHKRSYLGEIGNTVNYVHKENFVQYSPHQIGAIINGIENKVSMVAVCDGFLKKNVVLGSVKNDCINNSPYIEIPNISKLIGSDNTKFFENMKEIILRNDSRSKHIWPLEYSLINTPIVEDFYKRDINGQDLVHLTGKKKCFHDIRSSGLLVPIASFYEIITSALVDKMKTFSMLHKHVYQFAYAYYHYYNKYCRIKLYSYHKLIIAYGENRDQLVFLTYKAIKDSFLLSFGQDLKQSFVNGDLSDSEYQDSSTLWNPHNLVASFLSEKSGRKNFLPELVDYLINTTRPLTSLYNGIRHKIICSSGLTQILIGENIYSEEFDIQLIPHSEHNFKVICGRMTIEIFMYAKGYVYIKDSSYEKPKLYGLKEFLKMYGGNVVDINTIEIDEILLEKGARSLPESKCADIEKVIRNPSSVPCFTNMNDEKNNKCMSVKDITGMDEKCREEYFSSSRDLIRISHDSFDKLLYQDSENKPISDFRNYLYSLRSFERLTTILVHNYGKPMLGGGGLTVHYAKVSHHIVKVTFSAAKRSDGSIPCNINFIIYLEPKTFRIRLKLEYIGSLRPTDDEIAIAEEYFEEVMKYTESPQMVYSFMNLIRLIIPKFFSCVTNLMLLQLNPDPLNFYTMNFEFVNVIQRKDDSMPKYVPQILINELSGRILIPITIKPQKVDFNNKNNDINNKIKLDFVWDAANNEVYIHNANDDFFKMINQKIIQFNNTVKESLECTLEACIRYILKSEIKST
Length1355
PositionTail
OrganismStrongyloides ratti (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.11
Grand average of hydropathy-0.250
Instability index40.46
Isoelectric point8.66
Molecular weight157011.80
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01517
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.39|      16|      27|     151|     175|       1
---------------------------------------------------------------------------
  134-  149 (28.58/ 7.77)	LC.IPIQNFLDQQLQQY
  156-  172 (25.82/33.67)	LCgIARGELTYARMPQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1023.08|     345|     674|     232|     646|       2
---------------------------------------------------------------------------
  232-  619 (507.05/480.64)	RIKnIITNNGtVTLVVPG......EFEITLtLPGETLNvkWKLLRVRILIHDYEFGDGkelvhYLQLKkihkfcQKLLDRSKkpLISVYNFLH.......DFCiTLQFDLIfgeILEL.TQGIYKNKVfIDFCNVQRRYISLAYWVN.KKTKKNQSPNYQIVFSIPKKSRN...SGIVVEYRPS.DSFPIESYKEFEEKP..SVHNILKS.........VIEYNvYKKLILLKEQLEKCNPKLNVRLTgdllpKVTFYLLNKNiDGdddELSFGVNFFtgEYMYVGDELKE.SLLLKATIFGLN.NNIDTKKlEKCLDGIRTEFIMKKYIKSVNM....LN.VKLVMEKTLPSIFRK.........YAYFEH..SIKLY.FQIikepqcyITITFTDPKKKGLCI.NF......FLLS.TNEGKSTIIK..LNPFDFYNPSKI.NTHK
  725-  875 (74.79/26.83)	........................................................................................................................................................................................................................................................................................EYSLINTPIVE.D.FYKRDINGQDlVHLTGKK..KCFHDIRSSGLLVPIASFYEI....IT.SALVDKMKTFSMLHKhvyqfayayYHYYNKycRIKLYsYHK.......LIIAYGENRDQLVFL.TYkaikdsFLLSfGQDLKQSFVNgdLSDSEYQDSSTLwNPHN
  913- 1246 (441.24/341.20)	RHK.IICSSG.LTQILIGeniyseEFDIQL.IPHSEHN..FKVICGRMTIEIFMYAKG.....YVYIK......DSSYEKPK..LYGLKEFLKmyggnvvDIN.TIEIDEI...LLEKgARSLPESKC.ADIEKVIRNPSSVPCFTNmNDEKNNKCMSVKDITGMDEKCREeyfSSSRDLIRIShDSFDKLLYQDSENKPisDFRNYLYSlrsferlttILVHN.YGKPMLGGGGLTVHYAKVSHHIV.....KVTFSAAKRS.DG...SIPCNINFI....IYL..EPKTfRIRLKLEYIGSL.RPTDD...EIAIAEEYFEEVM.KYTESPQMvysfMNlIRLIIPKFFS...................................................CVtNL......MLLQ.LNPDPLNFYT..MN.FEFVN.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.01|      37|     609|     677|     713|       5
---------------------------------------------------------------------------
  677-  713 (65.01/47.59)	KNDCINNS...PYI.EIPNISKLIGSDNTKFFENMKEIILR
 1287- 1327 (55.00/38.86)	KNNDINNKiklDFVwDAANNEVYIHNANDDFFKMINQKIIQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01517 with Med14 domain of Kingdom Metazoa
Unable to open file!