<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01513

Description Cyclin-dependent kinase 19
SequenceMIDTKFRDELASKRERVELLYSFRGSKIGRGTYGHVYKATPRFETPENKGKTYALKLIEGNGISMSSCREIALLRELSHPNLIKLNRVFLSPERKVWLLFDYAEHDLWHIIKFHRNAKQKKQAVMVPKSMVKSLLFQILDGIHYLHTNWILHRDLKPANILVMGDDPYERGRVKVADMGFARTFHTPVRPLADLDPVVVTFWYRAPELLLGAKHYTKAIDIWAIGCIFAELLTSEPVFFCREEDIKASSPYHKDQLSRIFQVMGYPQDADWPDLKKMPEYQRLSKDFKRQTFSECALYKYLEKHKVKTNDKGFSLLQKLLTFDPLKRISAIDAINDAFFKESPKPTLDVFRGGPIPYPRREFMQDENEEKIIGKHIPQQNIQIQQHLINNIGTNKLVQQGNNQVRQISEPDIKSNQFSNITMANQTEFSHLNNHSGNLNQPPPQQVNVFNDGNQQNVVQMQQNQYNQQQIFTGHDQNRMILQQQQQQPVVQNTIRGPNGQFISQQQSRIISQDQNRMMIQQNQHQFNQQQQQLFVPHDQNRMMIQQQGRMIQSQGQNNMIPIQQQYIQQQQQHQIPQQQQQQQQQQQQMMQQQNFMWNQQQRYQ
Length604
PositionKinase
OrganismStrongyloides ratti (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.09
Grand average of hydropathy-0.791
Instability index49.68
Isoelectric point9.44
Molecular weight71131.15
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01513
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     278.93|      35|      35|     453|     487|       1
---------------------------------------------------------------------------
  378-  414 (34.21/ 8.02)	.Q.QN.IQIQQHLI..NnigtNKLVQQGNNQVRQISEPDIK..S
  415-  444 (37.06/ 9.20)	NQfSNITMANQTEF..S....H...LNNHSGN...LNQPPP..Q
  453-  487 (68.86/22.42)	NQ.QNVVQMQQNQY..N....QQQIFTGHDQNRMILQQQQQ..Q
  490-  525 (52.34/15.56)	VQ..NTIRGPNGQFisQ....QQSRIISQDQNRMMIQQNQH..Q
  527-  552 (33.79/ 7.85)	...........NQ...Q....QQQLFVPHDQNRMMIQQQGRmiQ
  555-  582 (52.68/15.70)	GQ.NNMIPIQQ.QY..I....QQQ.....QQHQ.IPQQQQQ..Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.18|      34|      37|      90|     125|       2
---------------------------------------------------------------------------
   65-   89 (40.47/23.19)	MSSCREI.ALLRELSH..PNL......IKL.......NR.VF
   90-  125 (57.35/42.17)	LSPERKV.WLLFDYAE..HDL...WhiIKFHRNAKQKKQAVM
  126-  163 (41.36/23.85)	V.PKSMVkSLLFQILDgiHYLhtnW...ILHRDLKPANILVM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.11|      23|      39|     191|     217|       3
---------------------------------------------------------------------------
  191-  217 (33.98/32.57)	LADL...DPVvvtFWYRaPELLLGAKHYTK
  228-  253 (38.13/23.55)	FAELltsEPV...FFCR.EEDIKASSPYHK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.87|      17|      76|     265|     287|       4
---------------------------------------------------------------------------
  256-  276 (27.05/24.78)	LSRIFqvmgYPQDADWPDLKK
  283-  303 (24.82/ 7.89)	LSKDFkrqtFSECALYKYLEK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01513 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QFNQQQQQLFVPHDQNRMMIQQQGRMIQSQGQNNM
2) QQGNNQVRQISEPDIKSNQFSNITMANQTEFSHLNNHSGNLNQPPPQQVNVFNDGNQQNVVQMQQNQYNQQQIFTGHDQNRMILQQQQQQPVVQNTIRGPNGQFISQQQSRIISQDQNRMMIQQNQ
525
398
559
523










Molecular Recognition Features






MoRF SequenceStartStop




NANANA