<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01512

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDDRPFNLQPPAAKPRGPQNIAEFWARARSQPGGIQAMVAARRAKAAAAEQKNGQNDVEMTDSNEAEEPAETEAEESTETPDINAVRAELLQQTQAALATSNWALDFLSLLISREMPTQATSTLSQETRATVGLGTLGATMLAAPTALAQSRETEMRMTAIGQRYLALDNCISMAKPAQSRLEHQIQAEEKYWAEVSTVKEAGFRVARMAQEPQTMCVSFGFLNAAPEFKNSGIAPLRRADDGSVKLELGRRGGGSRRIRVRILENDKVVGQSSLPDPLPENATLVDRVKDARNTIFAQELWHEINREARTLGGRNVRMSRSSVTYAMSPTSTMSVELASLEEENAKDTTGSPRPKDDVAEMLSLALALQLSHAHKINERRREDRNAVQTSAPVYSLLGPIVSWFEHERNIAQFIQHLLAYSKALRSAGLPASVLVREPPVRTPPGAGTAADSENIGPVLYSPPAVEFDVDITPQSRLRVMVKPPQSDGPRFAVWTLPPPTSSQPGSGNPLQSVFPPSPDEYFDANDAVWYINGAVPRALTAHSMLVLEGLKGNSSSGEEGLARWATRSDEKGLVDETGGFGIGFEFTFSEGGPELKVTGAFAEGGEKVSRQWVWGLGSQAGEALEDVVRQVLSSCLDT
Length639
PositionHead
OrganismPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Podospora> Podospora anserina.
Aromaticity0.06
Grand average of hydropathy-0.416
Instability index53.81
Isoelectric point5.20
Molecular weight69339.00
Publications
PubMed=18460219
PubMed=24558260

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01512
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.28|      23|     471|       9|      33|       1
---------------------------------------------------------------------------
    9-   33 (41.16/26.96)	QPPaaKPRGPQ.NIAEFWARARSQPG
  483-  506 (42.12/22.18)	KPP..QSDGPRfAVWTLPPPTSSQPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.60|      23|      23|     120|     142|       2
---------------------------------------------------------------------------
  120-  142 (35.22/21.60)	ATSTLSQETRATVGLGTLGATML
  144-  166 (36.38/22.55)	APTALAQSRETEMRMTAIGQRYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.26|      18|      26|     281|     305|       3
---------------------------------------------------------------------------
  281-  298 (30.10/30.95)	ENATLVDR.VKDARNTI.FA
  308-  327 (22.16/ 6.07)	EARTLGGRnVRMSRSSVtYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.38|      38|     220|     173|     213|       5
---------------------------------------------------------------------------
  173-  213 (61.44/41.58)	SMAKPAQSRLEHQ......IQaeeKYWAEVSTVKEAGFRVARMAQEP
  396-  439 (58.94/33.24)	SLLGPIVSWFEHErniaqfIQ...HLLAYSKALRSAGLPASVLVREP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.16|      15|      17|     598|     612|       7
---------------------------------------------------------------------------
  598-  612 (26.34/15.18)	VTGAFAEGG...EKVSRQ
  614-  631 (22.82/12.21)	VWGLGSQAGealEDVVRQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01512 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GPRFAVWTLPPPTSSQPGSGNPLQSVFPPS
2) IQAMVAARRAKAAAAEQKNGQNDVEMTDSNEAEEPAETEAEESTETPDINAVRAELL
489
35
518
91










Molecular Recognition Features






MoRF SequenceStartStop




1) AAKPRGPQNIAEFWARARSQPGGIQAMVAARRAKAAAA
12
49