<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01508

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMVVCGYTLGLVGEGHFRPVDLFKSRMSGGDPINTPSSSSSAGFAADMGLQRAQSFNMPTPTTVGNVVLADVKGYASVPIPEIHRYFMKAALESLTTYFCRQIGAIALNPRAVLLPPEALNTDDADHVSALATFRVYLTTTGTLVISLNVSLSKSLVACSRPFQGSMMPPSPILAAPFGHFGTLQGILDTDNQGTENGFVQSPDTQIGRLRSGSGERFSQWKTLVCEVLKMHGMSSSILNGCSWLNVHFSQRKPYEQRGDGKNTPLVNSGPNAPWPSVLCFRRARVEPVSDVDFDKAVPGNAGEHGDPLSMVKSWCQGLSKREEDMSQRKKEREAALLREKAEVDGRNIQLNGHSPMNPRRPSNAGPALTAAGVMYPTPPDGVLQPGVMPLFDGTTVSPANLPPQNVVVDMEVNIQQDVSMTDGFGVGWDGQESKPEPTTAGFTDEHMYGDLDEDMFGGNELTDADFSFFDQPADNLDLDSHQVDGTGPSMDLQLTNNTAAQEPGRATQGPNSRQPGPTNAQPQFTKPELKHARSILAESRQQINAQNFNHNSAVGIKRQTSPFNPETVFKKIKASLQPVPPSRVAPKGGPPRRRSVYERVEFNPALSLDSVKYQASGPFTYQPPTLNSYLPNEGPLTTGRLLGSAKQRRNIKELSFDLLGLQKRINGAGASPAKRDEGLSDDDESSLESDDDTTSNVSARASSPAKSSVLRRRPDDDVISMAASFKDLENYATDSPGYSPNDLIRLSNSEVPELSLTRWFADPEPVPLRISVSDDDFITVAQVLTEQAAGGTLRLEPERPCSEIRDTRQGLVDAIRYSIQGLQRALPRALMGATECHFRAFAEVQDVPLLVQPVQPQSRVQMRPADLGRPTFQILPVPHIEVRRNNGQLALLPSALTFWESLGLGPAQGAKDVVAVCVFPHGEGMRDNATVFLERMRSMYELMNFGSHAKLPTTASIVDGLVSVPIDQGFVSPGMHLSRPHSIYTDHMANLALSLANVPMTEKNFVVYFAYNPENPTSIVDSCCAFQELFEHYKRCMLERKKQILNELVLQLIPLDLIASDTSMVVLPTPECMRLCIETYDRCTLFGGPMPAPAIILESALPREVPFRISPTPSPDVLHENSHMHVAYAQSTDERWVTAAWTDPRGQKQMTASYCLGRRNKPLTRHISEVISEIWETTYDLISSCKVSWKIIVTKSGVMEPQEADLWIAKSQDEHRVVTSLTLVVVDANPSLQLVPPVVRVPPAGVHAAFYTTPVSTPQPFSVLSPEQGNNNPSTPTVVSSSHNNPATPNDNTNNDGGQGGDGNGVERTVVDVWDSVYSVVVAHRLSNSLGLTEINPAWASGYLVRRNASRGEDVPGVMEVGLVWCEQVNARGVGYEGVLREVMGEFRGLGTLARARGCMTEERDLRPWHVGVVERGCRVLGLLM
Length1425
PositionKinase
OrganismPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Podospora> Podospora anserina.
Aromaticity0.07
Grand average of hydropathy-0.331
Instability index53.53
Isoelectric point5.56
Molecular weight155576.04
Publications
PubMed=18460219
PubMed=24558260

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01508
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     287.30|      56|     127|     384|     439|       1
---------------------------------------------------------------------------
  384-  439 (95.24/59.10)	QPGVMPLFDGTTVSPA.NLPPQNVVVD.....MEVNIQQDVSMTDGFGVGWDGQESK.PEPTT
  462-  519 (63.60/36.43)	TDADFSFFD....QPAdNLDLDSHQVDgtgpsMDLQLTNNTAAQEP.GRATQGPNSRqPGPTN
  522-  567 (53.07/28.89)	.....PQF....TKPE.LKHARSILAE...srQQINAQ...NFNHNSAVGIKRQTSP.FNPET
  573-  625 (75.39/44.88)	KASLQPV.PPSRVAPK.GGPPRRRSVY.....ERVEFNPALSL.DSVKYQASGPFTY.QPPT.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.81|      23|      39|     864|     886|       2
---------------------------------------------------------------------------
  864-  886 (42.26/29.57)	PADLGRPTFQILPVPHIEVRRNN
  906-  928 (42.55/29.83)	PAQGAKDVVAVCVFPHGEGMRDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.88|      20|     908|     363|     382|       3
---------------------------------------------------------------------------
  363-  382 (37.54/18.45)	NAGPALTAAGVMYPTPPDGV
 1227- 1246 (36.34/17.61)	DANPSLQLVPPVVRVPPAGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     259.47|      84|     654|      93|     188|       4
---------------------------------------------------------------------------
   93-  188 (130.28/106.41)	SLTTYFCrqigaialNPRAVllpPEALNTDDADHVSaLATFRVYLTTTGTLVI......SLNVSLSKSLV.ACSRPFQGSMMP.PSPILAAPFGHFGTLQGILD
  755-  846 (129.19/79.99)	SLTRWFA........DPEPV...PLRISVSDDDFIT.VAQVLTEQAAGGTLRLeperpcSEIRDTRQGLVdAIRYSIQGLQRAlPRALMGATECHFRAFAEVQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.13|      38|     839|     261|     331|       5
---------------------------------------------------------------------------
  233-  276 (67.89/76.41)	MSSSILNGCSWLNVHFSQRKPY........eqrgdgKNTPLVNSGPNAP.WPS
  310-  362 (58.24/18.47)	MVKSWCQGLSKREEDMSQRKKEreaallrekaevdgRNIQLNGHSPMNPrRPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.68|      22|      46|     933|     954|       9
---------------------------------------------------------------------------
  933-  954 (41.19/27.06)	LERMRSMY..ELMNFG.SHAKLPTT
  977- 1001 (31.49/18.94)	LSRPHSIYtdHMANLAlSLANVPMT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01508 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) INGAGASPAKRDEGLSDDDESSLESDDDTTSNVSARASSPAKSSVLRRR
2) NELTDADFSFFDQPADNLDLDSHQVDGTGPSMDLQLTNNTAAQEPGRATQGPNSRQPGPTNAQPQFTKPELKHARSILAESRQQINAQNFNHNSAVGIKRQTSPFNPETVFKKIKASLQPVPPSRVAPKGGPPRRRSVYERVE
3) PFSVLSPEQGNNNPSTPTVVSSSHNNPATPNDNTNNDGGQGGDGNGV
4) SGPFTYQPPTLNSYLPNEGPLTTGRLLGSA
5) SKREEDMSQRKKEREAALLREKAEVDGRNIQLNGHSPMNPRRPSNAGPALTAAGVMYPTPPDGVLQPGVMPLFDGTTVSPANLPPQNVVVDMEVNIQQ
6) VSMTDGFGVGWDGQESKPEPTTAGFTDEHMYGDLDEDMFG
665
459
1260
616
319
418
713
601
1306
645
416
457










Molecular Recognition Features






MoRF SequenceStartStop




1) ELTDADFSFF
2) RRRSVYERVEF
3) TVFKKIKASLQPV
460
592
567
469
602
579