<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01508

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMVVCGYTLGLVGEGHFRPVDLFKSRMSGGDPINTPSSSSSAGFAADMGLQRAQSFNMPTPTTVGNVVLADVKGYASVPIPEIHRYFMKAALESLTTYFCRQIGAIALNPRAVLLPPEALNTDDADHVSALATFRVYLTTTGTLVISLNVSLSKSLVACSRPFQGSMMPPSPILAAPFGHFGTLQGILDTDNQGTENGFVQSPDTQIGRLRSGSGERFSQWKTLVCEVLKMHGMSSSILNGCSWLNVHFSQRKPYEQRGDGKNTPLVNSGPNAPWPSVLCFRRARVEPVSDVDFDKAVPGNAGEHGDPLSMVKSWCQGLSKREEDMSQRKKEREAALLREKAEVDGRNIQLNGHSPMNPRRPSNAGPALTAAGVMYPTPPDGVLQPGVMPLFDGTTVSPANLPPQNVVVDMEVNIQQDVSMTDGFGVGWDGQESKPEPTTAGFTDEHMYGDLDEDMFGGNELTDADFSFFDQPADNLDLDSHQVDGTGPSMDLQLTNNTAAQEPGRATQGPNSRQPGPTNAQPQFTKPELKHARSILAESRQQINAQNFNHNSAVGIKRQTSPFNPETVFKKIKASLQPVPPSRVAPKGGPPRRRSVYERVEFNPALSLDSVKYQASGPFTYQPPTLNSYLPNEGPLTTGRLLGSAKQRRNIKELSFDLLGLQKRINGAGASPAKRDEGLSDDDESSLESDDDTTSNVSARASSPAKSSVLRRRPDDDVISMAASFKDLENYATDSPGYSPNDLIRLSNSEVPELSLTRWFADPEPVPLRISVSDDDFITVAQVLTEQAAGGTLRLEPERPCSEIRDTRQGLVDAIRYSIQGLQRALPRALMGATECHFRAFAEVQDVPLLVQPVQPQSRVQMRPADLGRPTFQILPVPHIEVRRNNGQLALLPSALTFWESLGLGPAQGAKDVVAVCVFPHGEGMRDNATVFLERMRSMYELMNFGSHAKLPTTASIVDGLVSVPIDQGFVSPGMHLSRPHSIYTDHMANLALSLANVPMTEKNFVVYFAYNPENPTSIVDSCCAFQELFEHYKRCMLERKKQILNELVLQLIPLDLIASDTSMVVLPTPECMRLCIETYDRCTLFGGPMPAPAIILESALPREVPFRISPTPSPDVLHENSHMHVAYAQSTDERWVTAAWTDPRGQKQMTASYCLGRRNKPLTRHISEVISEIWETTYDLISSCKVSWKIIVTKSGVMEPQEADLWIAKSQDEHRVVTSLTLVVVDANPSLQLVPPVVRVPPAGVHAAFYTTPVSTPQPFSVLSPEQGNNNPSTPTVVSSSHNNPATPNDNTNNDGGQGGDGNGVERTVVDVWDSVYSVVVAHRLSNSLGLTEINPAWASGYLVRRNASRGEDVPGVMEVGLVWCEQVNARGVGYEGVLREVMGEFRGLGTLARARGCMTEERDLRPWHVGVVERGCRVLGLLM
Length1425
PositionKinase
OrganismPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Podospora> Podospora anserina.
Aromaticity0.07
Grand average of hydropathy-0.331
Instability index53.53
Isoelectric point5.56
Molecular weight155576.04
Publications
PubMed=18460219
PubMed=24558260

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01508
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     287.30|      56|     127|     384|     439|       1
---------------------------------------------------------------------------
  384-  439 (95.24/59.10)	QPGVMPLFDGTTVSPA.NLPPQNVVVD.....MEVNIQQDVSMTDGFGVGWDGQESK.PEPTT
  462-  519 (63.60/36.43)	TDADFSFFD....QPAdNLDLDSHQVDgtgpsMDLQLTNNTAAQEP.GRATQGPNSRqPGPTN
  522-  567 (53.07/28.89)	.....PQF....TKPE.LKHARSILAE...srQQINAQ...NFNHNSAVGIKRQTSP.FNPET
  573-  625 (75.39/44.88)	KASLQPV.PPSRVAPK.GGPPRRRSVY.....ERVEFNPALSL.DSVKYQASGPFTY.QPPT.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.81|      23|      39|     864|     886|       2
---------------------------------------------------------------------------
  864-  886 (42.26/29.57)	PADLGRPTFQILPVPHIEVRRNN
  906-  928 (42.55/29.83)	PAQGAKDVVAVCVFPHGEGMRDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.88|      20|     908|     363|     382|       3
---------------------------------------------------------------------------
  363-  382 (37.54/18.45)	NAGPALTAAGVMYPTPPDGV
 1227- 1246 (36.34/17.61)	DANPSLQLVPPVVRVPPAGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     259.47|      84|     654|      93|     188|       4
---------------------------------------------------------------------------
   93-  188 (130.28/106.41)	SLTTYFCrqigaialNPRAVllpPEALNTDDADHVSaLATFRVYLTTTGTLVI......SLNVSLSKSLV.ACSRPFQGSMMP.PSPILAAPFGHFGTLQGILD
  755-  846 (129.19/79.99)	SLTRWFA........DPEPV...PLRISVSDDDFIT.VAQVLTEQAAGGTLRLeperpcSEIRDTRQGLVdAIRYSIQGLQRAlPRALMGATECHFRAFAEVQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.13|      38|     839|     261|     331|       5
---------------------------------------------------------------------------
  233-  276 (67.89/76.41)	MSSSILNGCSWLNVHFSQRKPY........eqrgdgKNTPLVNSGPNAP.WPS
  310-  362 (58.24/18.47)	MVKSWCQGLSKREEDMSQRKKEreaallrekaevdgRNIQLNGHSPMNPrRPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.68|      22|      46|     933|     954|       9
---------------------------------------------------------------------------
  933-  954 (41.19/27.06)	LERMRSMY..ELMNFG.SHAKLPTT
  977- 1001 (31.49/18.94)	LSRPHSIYtdHMANLAlSLANVPMT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01508 with Med13 domain of Kingdom Fungi
Unable to open file!