<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01506

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMEGPATAGSSLTGLPAAVARWEQLITRARLQRLDPDQFAVFSKILLVKHPLPPGLIAELLLRPTADNNVALDPRAPLYLTHLIKQRRVDTASVLKALYNYSTIHTKIHPQPEDQPSKERDASAPRRKKLQRWTSSYSSEAILFWRLAQTVNQGIGIKSGRDVVETSRMLVRWMALFTEAATIFSQDAFGSMHSLNASKLGMERSRESFIMFLNAFSAHPTVPKTFQIPAAKGIRKQLSQSLEAFLPSIMQVNPSIASQLDMFRAQSLATHDSTEKKDPAVSDMNSYMDNVMGLESFQVPEVPIANTRAGLYIYLSAALVGRPMIDDAALFTYLHNRYRGDVQQAAVQLILASFDVLANAVFRNEGAKAGHLLKSFVVNKVPLVLVSLAQSSPLYTFNPEICITEALGQVDTNIFPTFSGMFDMSSNTGSSFQDSVRQDFCFACQLHGLLSQAAIENLLGDITYQTLPDEGRYVKDILVQSCLQDSDRTQKLIGELDNMNGNVGAAAQAVVEVIGSLCRNTETMALKQLCGQLASKPLSLDILLLFSPAQKILHPLRELIDHWGGYDEEQGEYQPVYEEFGSVLLLLMAFVYRYNISPADLGVRSPDSFVGKLIGGGHAVRLLSDLSPQEHLHLNGWIQGLFAEGGLGDELMASCPPQDFYLLMPVLFGQISAALSAGFLNEETLKSGLECEFHFWSGIWMILTAADLVEVFLLPSLVPAILYLSNQLWAEGPEGQRSIIKILQLLIRPNSISNEASAMFQSVLNIVAKPLEHALRSYQRSDPKSQEVEPLLRAIKENLTVSRRTGGADHAELESWTTTHGSHTPGSHPNATPLPGGLAATNRPPQAQHPDGGISAAVRHTVQSLANWVQQAPLGGNTTPTAYTHRQTLAALKLLGARQLLTVLLDELKTLTESGQGSVAYDVVCSLVCAPDVTNDTSLASSDTPNDGTAGGAGAFAAAPPPPVQRRLTLREVLKHEADDWKRIQKQDPVMAETVVRLYRQVEGQMEMPQTAVAGLLGQQDMVSGLGVVGGDVMGDAMAAAAAAAAVQGVGDGVSVVEGMSIDTSGLGGVDNNYDGGVDLGSAGGSAIGGGGGGGGDLDGDNIFGGLPTLVGADFDGGGFGGWGDMDLT
Length1128
PositionTail
OrganismPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Podospora> Podospora anserina.
Aromaticity0.07
Grand average of hydropathy-0.039
Instability index45.08
Isoelectric point5.22
Molecular weight121313.57
Publications
PubMed=18460219
PubMed=24558260

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364142
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01506
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.74|      27|      27|    1072|    1098|       1
---------------------------------------------------------------------------
 1045- 1070 (30.96/12.56)	AVQGvGDGVSVVEGMSIDTSG.LGGVD..
 1072- 1098 (50.18/24.99)	NYDG.GVDLGSAGGSAIGGGG.GGGGDLD
 1101- 1126 (44.59/21.38)	NIFG.G..LPTLVGADFDGGGfGGWGDMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.76|      24|      27|     615|     641|       2
---------------------------------------------------------------------------
  615-  641 (37.73/41.45)	GGHAVRLLSDLSPQEHLHLngwIQGLF
  644-  667 (46.04/36.61)	GGLGDELMASCPPQDFYLL...MPVLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.50|      12|      27|     212|     228|       3
---------------------------------------------------------------------------
  212-  228 (17.18/24.44)	LNAFsahptVPKTFQI.P
  241-  253 (18.32/ 9.85)	LEAF.....LPSIMQVnP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.28|      18|      22|     845|     865|       5
---------------------------------------------------------------------------
  845-  865 (24.03/25.66)	QAqhPDGG..ISAAVRHTvQSLA
  870-  889 (30.24/18.03)	QA..PLGGntTPTAYTHR.QTLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.83|      26|      27|     674|     699|       6
---------------------------------------------------------------------------
  674-  699 (48.74/34.80)	LSAGFLNEETLKSGLECEFHFWSG.IW
  702-  728 (39.09/26.30)	LTAADLVEVFLLPSLVPAILYLSNqLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.00|      11|      77|     293|     303|      10
---------------------------------------------------------------------------
  293-  303 (20.61/13.77)	LESFQVPEVPI
  372-  382 (19.40/12.52)	LKSFVVNKVPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01506 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGADHAELESWTTTHGSHTPGSHPNATPLPGGLAATNRPPQAQHPDGGISAA
805
856










Molecular Recognition Features






MoRF SequenceStartStop




NANANA