<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01503

Description Putative Mediator of RNA polymerase II transcription
SequenceMTSRPPLGVQQRQPQQHSLAGPGLSQRPAAHQRALSQQQQFLPPSPIRKETGSFEFTPPDYNDGANTRYPGQRRGGSRLKLELSHESLESITHTGIIESPNAIDTSKPFTPSRMMLPTDSSDLGDMSPHFSHLPTVDLDAPLPMPQRRLRITLPRRDPPPIPSTTTRKDVPPKPYQVEVPSAAPRYYTHGKVEARPRKGGTASTAGHLAPPPSIGYADFYPWMGNHPEDQFSENVIRQGHFDKPAFNPDTQLGKYAIFPSMKGANSSLHTLSAIFTAALGARRNNGQIASHSTFRYPPRVTVTDTKRELWLKDLANPASSLRRLARTIPHGLRNQALLEQCLNKRIPFERAVWLIQCVGANELRTCKRKGVSLAQSFAAEVRWIKDWTVSVQKFVENVLFSFDDKDWKARVQYVVLLATHLYEQYLLDRETYMEWLVSSFENSNQNRLPMWMLITEIYWKDLLKLRRYGRRLVTALISHHQLVFNHPDRDILQPLLSKTTTLLNTLILSSPENFVSPSVWSKYRDTIKACLPVGDTERHDAFAAIGSRNEQLMASGNRSQPAARHILVQWLDRNTQAPMSEEGPANSWNISKDKSALARALLEWCTSLYRPGKTKVYIAGQLLQHWSMLGLDVTTEILDFLDADPCAQKERKDHLYHLVCELVRSNDFSVPRYIQWLSARGGITNPEDILPDGPASTRLLAEIPPFGLSSEQRNLRSGMLRRASFSVDDEARDAEMALKLVRQSLGLPLDPADPIRQRKPRSINKISQQIQTASRALKAEIGRWLRDSVASTYGGKDKTGSSGPGASPTLFGSIRQILEAAEDLSMLADVLRSLISNACVEVLTAIANTVNRHFFIFSALGVSKGLFNDLSKKLRAVYLEQGPGARPLLVSLVSLAPRIPGMDELATQLRKDLALSSRQNPVDACSPVSDNMIARLQDDSNDLHEEIEKLLAAGTSVDRKTMENLFQTIIQRLHQSWGESAAKQRVCSVLLARLRVFDMPLFDALMAKWIAYLRTLTNRPSIDRIFPLLVSNGCLTMPTILASTSDSSTPTPITRVPTGGASWPQIVQITYRTRYMQETLKLLMNPLRPDYDLITPEEIYRFTNLQEQVLRENPKDMLALIGSAMAEYSFARAQNDTRGLPLDDPIIQERLSTLIKLLVLKDAAGVGRALAAWAARSPDGYVGSWIDNMTTKLLLPSADRHTHITFDQILELTNEFTWPFCHLQLFLQTSTPPTDQSNNQQAPAADRQPSTLDSLTSAMDRAIDKKNLTWVGIVLSLNVEVVQQLKGRAQSRFLGLIPSPREPLPVNTAGPVPEQSLQMAENLLSVIEALMRGSPPGARQPQLPPEVVIKLSDLWELVANPELDLSAKQQIITRWLPLLLNFITLHTQAFDASKASSDIRARLLVVCAGLMQELDALHGPGAHTRGLAARVFDLGCVLSDNLPEEQRGQCVRALFGTGSGNGGGDGRLRYLLSWAGSGSNGCEGIWVSVRERGRQVAMGGQQQGQVMKDGVGFAVEKLAVPGGLWSGTTTATPGVVVGGNNGGQQQQQQQQTVAGVGGGERLTPFGMRKWDIVHVPTGAVVENDTGLDLSLFEARGQKVWPAKQL
Length1605
PositionKinase
OrganismPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Podospora> Podospora anserina.
Aromaticity0.07
Grand average of hydropathy-0.318
Instability index45.23
Isoelectric point9.06
Molecular weight177986.22
Publications
PubMed=18460219
PubMed=24558260

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01503
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.64|      39|      83|     803|     842|       1
---------------------------------------------------------------------------
  803-  842 (61.14/40.95)	GPGASPtLFGSIRQILEAAEDLSMLADVLRSLIS........NACVEV
  882-  928 (58.50/34.76)	GPGARP.LLVSLVSLAPRIPGMDELATQLRKDLAlssrqnpvDACSPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.49|      21|      51|    1474|    1495|       2
---------------------------------------------------------------------------
 1479- 1528 (24.61/15.45)	SNGCEGIWVSVRERGRQvamggqqqgqvmkdgvgfaveklavpgglWSGT
 1529- 1556 (28.88/13.09)	TTATPGVVVGGNNGGQQ......................qqqqqqtVAGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     216.52|      68|      84|    1277|    1347|       4
---------------------------------------------------------------------------
 1277- 1347 (109.16/64.28)	LNVEVVQQLKGRAQSRFLGLIPSPREPLPVNTAGP.VPEQSLQMAENLLSVIEALmrgSPPGARQPQLPPEV
 1363- 1431 (107.36/56.35)	LDLSAKQQIITRWLPLLLNFITLHTQAFDASKASSdIRARLLVVCAGLMQELDAL...HGPGAHTRGLAARV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.00|      35|     105|     551|     585|       5
---------------------------------------------------------------------------
  551-  585 (64.05/34.77)	QLMASGNRSQPAARHILVQW....LDRNTQAPMSE....EGPA
  607-  636 (29.52/12.19)	SLYRPGKTKVYIAGQLLQHWsmlgLDVTTE.............
  661-  695 (49.42/25.20)	ELVRSNDFSVP..RYI..QW....LSARGGITNPEdilpDGPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.02|      25|      83|     194|     218|       6
---------------------------------------------------------------------------
  194-  218 (44.42/31.31)	ARPRKGGTASTA.......GHLAPPPSIGYAD
  234-  265 (34.82/22.46)	NVIRQGHFDKPAfnpdtqlGKYAIFPSMKGAN
  281-  304 (38.77/26.10)	AR.RNNGQIASH.......STFRYPPRVTVTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.44|      26|      74|      18|      43|       8
---------------------------------------------------------------------------
   18-   43 (44.30/28.95)	SLAG...PGLSQRPAA..HQRA.LSQQQQ....FLP
   90-  117 (37.22/22.81)	SITH...TGIIESPNAidTSKP.FTPSRM....MLP
  121-  154 (29.92/16.48)	SDLGdmsPHFSHLPTV..DLDApLPMPQRrlriTLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     173.14|      48|      83|     397|     449|       9
---------------------------------------------------------------------------
  398-  449 (75.59/61.07)	VLFSFDDKDwkarVQYVVLLATHLYEQYLLD.RETYME...WLVSSFENSNQNRLP
  450-  481 (37.28/18.66)	................MWMLITEIYWKDLLK.LRRYGR...RLVTALISHHQ....
  482-  532 (60.27/34.10)	LVFNHPDRD...iLQPLLSKTTTLLNTLILSsPENFVSpsvW..SKYRDTIKACLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.02|      25|      42|    1119|    1144|      10
---------------------------------------------------------------------------
 1119- 1144 (38.70/27.72)	ALIGSAMAEYSfARAQNDTRGLPLDD
 1164- 1188 (46.33/28.41)	AGVGRALAAWA.ARSPDGYVGSWIDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.65|      36|      42|     706|     744|      11
---------------------------------------------------------------------------
  706-  744 (50.31/36.12)	FGLSSE......QRNLRSgmLRRASFSVDDEAR..DAEMAlKLVRQS
  745-  788 (51.34/26.81)	LGLPLDpadpirQRKPRS..INKISQQIQTASRalKAEIG.RWLRDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.91|      19|      43|     307|     326|      13
---------------------------------------------------------------------------
  307-  326 (27.54/20.17)	RELWLKDLANpASSLRRLAR
  350-  368 (35.38/20.83)	RAVWLIQCVG.ANELRTCKR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01503 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTSRPPLGVQQRQPQQHSLAGPGLSQRPAAHQRALSQQQQFLPPSPIRKETGSFEFTPPDYNDGANTRYPGQRRGGSRLKLELSHESLESITHTGIIESPNAIDTSKPFTPSRMMLPTDSSDLGDMSPHFSHLPTVDLDAPLPMPQRRLRITLPRRDPPPIPSTTTRKDVPPKPYQVEVPSAAPRYYTHGKVEARPRKGGTASTAGHL
2) TTATPGVVVGGNNGGQQQQQQQQTVAGVGG
1
1529
208
1558










Molecular Recognition Features






MoRF SequenceStartStop




NANANA