<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01502

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGAFRMENGTQNGVRSNHDREGWTNGVNGDNIKQEHRSEKGKGVAGGSGMEAGYAGNGPQVKLEELPDELQHITAEIIPLNMLLSRLAQYSHGALQDQILRLESMPLPQNLSNGNGNYHPTTQEDTSPESLEKKRMLLNFIQDLHTRWVKALVLTEWSKKADQVGKLIDIRTHLASKLELFSVTIWEMIKTKQDMLWAKIPSPDLKTALEVLARPKIHWMPDFDYLPLPEITPEESDAWIEEVNTLLSARLSLEEFERIPAPFADYKIDSGVATFSIPGEFEVDLTIGDDDFEKQFWFIDLRMTYQPTPPPLSEQARLAAETKINNALGTDGLLGAYNYLHDLTLTAKIGEFTRQAWQLRAGRWADCLQVERLNRAVAVHYWANRPHSKGNKSWIILGVNSSKGEDGRPDPKHPSYITLRWFRDGVEVKDFDISFDVDNISMDSLLEAVISRHIEHMLSSMYNKLASKPRFTHKQGRLTLCGSRKTPGDFTLRMQVLDDKDVTVGMDLYTGAFTLQAQSPMAADVQRRLNTFANPAEEGANLLELLRCHYVTTALMSRAKSIRWMVSRGSPLSMDEMKSIVYSGPPSTREPFQTVWMKKVGWNPQWFIFMSMSLGGDQWWLVEIPNPQQQQRPGATGTRVKMYTKMPMATEQLRLSDQFFENLTLYATGMIAQITDLRELHSKRMAHTTREAVNYSLPAQIKMPTVYVRLSDMLGPKGGGRGLCWAQEYIPIVFKGVQADSPMKIIAEAKLTVTNRKRFQFLKGNVDHDVNYNPNIGQFSLRLRGEMGATVITLLTSRIQALDKLIELVEAIGRAGKAVVHQSVTLREVVFTYTDSVPTESPEQQAPNNTRQQQHRPWRVRLDLTKERGVKVDLERGNPHYPVIDYIREMANSPDFENLPSWLVLSLPLYRALEKLGGVEQPGVVVTVLHRGLNWVTIRWVVQGRKVNVEVKPRRRQGTLMWSLSRVVDSPDSSSSKPPPPEQNDEFQKVLVEKVWNEKGNGWKGLTTGAAASLEGGVEEIVGLVDEVVRGVAVGGPQQQLPHHQGAPPQPTPQQQFQQAQAARFQQQMQQRQQQQMQPAANMTGGPPPPQPVIPQANMMNRGASGQGQQGRQGGTNQQGGYGSSMANALVLD
Length1134
PositionTail
OrganismPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Podospora> Podospora anserina.
Aromaticity0.07
Grand average of hydropathy-0.481
Instability index46.04
Isoelectric point7.73
Molecular weight127437.71
Publications
PubMed=18460219
PubMed=24558260

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01502
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.36|      14|      25|    1039|    1052|       1
---------------------------------------------------------------------------
 1039- 1052 (29.80/13.22)	QQQLPHHQGAPPQP
 1067- 1080 (26.56/11.00)	QQQMQQRQQQQMQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.36|      16|      25|     386|     401|       2
---------------------------------------------------------------------------
  386-  400 (24.84/12.91)	........RPHSKGNKSWIIL.....GV
  401-  427 (18.00/ 7.21)	NsskgedgRPDPK.HPSYITLrwfrdGV
  893-  906 (21.52/10.15)	N.......SPDFENLPSWLVL.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.05|      31|     110|     980|    1010|       3
---------------------------------------------------------------------------
  586-  607 (28.97/13.60)	.PPSTREPFQTVWMKKVgWNPQ...W......
  980- 1010 (59.67/37.20)	PPPEQNDEFQKVLVEKV.WNEKGNGWKGLTTG
 1088- 1116 (54.40/33.15)	PPPPQPVIPQANMMNR...GASGQGQQGRQGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.91|      72|     208|     279|     363|       4
---------------------------------------------------------------------------
  279-  363 (102.75/94.50)	PGEFEVDLTIGDDdfeKQfwfIDLRMTYQPTPPPLSEQARLAAE......TKINNALGtdgllGAyNYL.....HDLTlTAKIGEFTRQAWQLRAG
  488-  570 (115.17/68.04)	PGDFTLRMQVLDD...KD...VTVGMDLYTGAFTLQAQSPMAADvqrrlnTFANPAEE.....GA.NLLellrcHYVT.TALMSRAKSIRWMVSRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.84|      20|     101|     914|     933|       5
---------------------------------------------------------------------------
  910-  929 (32.61/19.50)	LYRALEKLG...GVEQPGVVVTV
  930-  952 (29.24/16.70)	LHRGLNWVTirwVVQGRKVNVEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.62|      23|      24|      77|      99|       8
---------------------------------------------------------------------------
   67-   95 (32.90/17.65)	LPDElqhitaEIIPLNMLLSRLAQYSHGA
   96-  122 (37.72/21.28)	LQDQ..ilrlESMPLPQNLSNGNGNYHPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.07|      56|     503|     165|     228|       9
---------------------------------------------------------------------------
  165-  228 (81.01/81.10)	VGKLIDIRtHLASKleLFSVTIWEMIKTKqdmLWAKIPSPDLKTALEVLARPK.....IHWMPdfDYLP
  672-  732 (94.06/64.56)	IAQITDLR.ELHSK..RMAHTTREAVNYS...LPAQIKMPTVYVRLSDMLGPKgggrgLCWAQ..EYIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.85|      20|      33|       6|      27|      10
---------------------------------------------------------------------------
    6-   27 (34.33/28.44)	RMENGtqNGVRSNHDREGWTNG
   38-   57 (35.52/22.35)	RSEKG..KGVAGGSGMEAGYAG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01502 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MAGAFRMENGTQNGVRSNHDREGWTNGVNGDNIKQEHRSEKGKGVAGGSGMEAGYAGNGPQVKLEELPD
2) VAVGGPQQQLPHHQGAPPQPTPQQQFQQAQAARFQQQMQQRQQQQMQPAANMTGGPPPPQPVIPQANMMNRGASGQGQQGRQGGTNQQGGYGSSMANALVLD
3) WSLSRVVDSPDSSSSKPPPPEQNDEFQKVL
1
1033
963
69
1134
992










Molecular Recognition Features






MoRF SequenceStartStop




NANANA