<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01495

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMDVANGQKPLSGQSSATGSSGMDKGKEWQMELLMEKLRSKASTYKSLVETAKNLRMAMLDKRFAIDSAEKSQLQKCLDTLQHSIKVTSLQSMVERLESLTRQLGLKFMMSGPPGTELFISSDMFFLEVLLEPTGVVKDVKIHHEGKNEQQSCDVLVSCLSRGDFLDFTVQLEGLASIYQLNADKKVKCKAFSALQSLESDLGILAQLQTFIKEPFNLVHKSPVGILERRRGGHAMKLTYFVSPFDLIDQENRTCDALSSEIVIKRKIGHSVTVCMEGSTAHKLPTSSIITVNRSPTGKSTPSYAPLTGTNSSVLPACFVLKLAKKMPMCMELVRRIQKVTELECGDISAPHPLLSLIIQHASEGQLDCRNNRGLYVTLPDQQHCYFMTENKNMEGVLVCSIPFTHPAHVPQILVYLRQQALFNTLIASCVRPMARQDPEHATIFEVNALSWQHISVSLEHPFEETMATAELDLTDISALKCKLYGISITNTEQTSDLTGKVLQKCLSIPLTMRILMKSWESRDSLSTMNNLNSGNGNYNVNLGSGKDQNSQNGSGMPDFTNGETKIKQEPGLNNGNGTMGRQQSSQQQQQQQPQQQPFLDAGTENSIGFPSYSGQSDTTTTAMLNPLQLGALLGQAKNSMSNSVNERTKKTRKRKTADGIWRSPKRKGDESTEILLESSSSDSTPLGTPTGGRENLNETRTSTPTSATSLTSGLDFSNLDPTDILGTDKSSDYDIDNESEITEVHDLQDVEELIKRDRKSRKREEKKSPIIFEENKNLVPPSVSITPISSSSLGQTTNYNSVLTGMGLERRPGIEIIPIAPQTTLPSSITITPIPAPSQSKSLTDERRERKSSKGKSTEDKGKLEKRRKRKREDSPMGPPPDKIPSKQDPLSKPVSVSIKPTESPPNMSSRPSSPATTLRKFSPSPTHTSPLALVGKSSPTLKQSTNKPVQSPKHSPVYSSSPKHTPVPASVSPKHGTSSPKHGSSASTGKPSMSALKSAANSPSSKTTDSGQSKIKSSSSSSSKDSNREKERKTSSLAFGGSSGHQSPKTKSSSGKLKQLELIPSGETQSTMPSSGGSTPPSGNSELGKSAIAQQQARNRKGSLSAVIDKLKNAQHCTDDGSNGGAKSTTGSSNSSGQKERSVGSSSNKTAEGKCINKNSSMDTKNPAEYMVKHSSDGMKITINKTRTKDSKSGTNLKLSSSSASVATGTSSSSSTSSTNISGNSSPKTHTGLKPGVSSGPASKKPPTQTSPKLSGSSSSSSGSSGNKTTLLGQKMLSALKSISGSNSGSGNGTGGINVGSSGSSGLLSKNVMSSKSSSSSPKTTSSGVTDLSRNRDKSRLSKSSDKSIFPSKGIGDRKSSPSGLREESESERAFKLLAAHASMSNLSNLPNLPPQLVVEGLMKQLDTKFQIPKLSARANADSTDKKSEKLSMLPDSGKTLDNLASKQTSEQGKMQTLSNTSSTTSKSSSDDQSSQGRRDHVQTKPDNLSMTSAASVINLGTDNTSNILLPALSSGSTHDLDIPTNLSMQPSENESREKESSLNRSNTQFQSSSLNSTGIGKDDISASGPVMAVLPKGSEAQPTSKSVYPTMMTTGTLTSGNGTTSTNTGNGGTESLNLSIKPVDATMTKYKSDEKKQQQPQQQQQSQPPQQQQPQSQQQSSQSQQQSQQQQSQPQQVPSSGGSSSSSSLGTTVSSENSSSAMKATSTEILASTSQEAAEMLLDFSTPKDVAKSLNFTSIPERAMTQAASVRRNTPPPPPPAFPASPSLMDEALVGMGK
Length1780
PositionMiddle
OrganismApis mellifera (Honeybee)
KingdomMetazoa
Lineage
Aromaticity0.03
Grand average of hydropathy-0.698
Instability index60.16
Isoelectric point9.38
Molecular weight190040.38
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01495
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            13|     980.08|     106|     108|     928|    1033|       1
---------------------------------------------------------------------------
  424-  554 (45.10/ 9.19)	..................TLI.ASC.V.RPMarQDPEHA..T.......IFEVnalSWQH....IS.....VSLE.H..........P....FEETM......ATA...E....LDLTD..I...S....ALKcklygiSITN....TEQTSDltgkvlqkclsipltmrilmkswesrdslstmnnlnSGNGNY.NVNLGS..G.KD.....QNSQNG.S..............
  575-  643 (51.04/11.59)	G..........NG...TMGRQ.QSSqQ.QQQ..QQPQQQ..P.......FLDA...........................................G......TEN...S....IGFPS..Y...SgqsdTTT......TAMLN..PLQLGAL....................................LGQAK.NSMSNS..................................
  646-  754 (63.78/16.73)	E..........RT...KKTRK.RKT.A.DGI.wRSPKRK..GdesteilLESS...SSDSTPLG........TPT.GGrenlnetrTS....TPTSA......TSL...T....SGL.D..F...S....NLD.............P....TD.........................................ILGTDKSS..D.YD.....IDNESEiTevH..DLQdveeLI
  755-  878 (78.35/22.61)	KrdrksrkreeKK...SPIIF.E.E.N.KNL..VPPSVSitP.......ISSS...SLGQTTNYNS.....VLTG.MG........LE....R.RPGieiipiAPQ...T....TLPSS..I...T....ITP......IPAPS..QSKSLTD....................................ERRER.KSSKGKS..T.EDkgkleKRRKRK.R..EDSPMG......
  879-  935 (63.93/16.79)	..................................PPPDK..I.......PSKQ...DPLSKPVSVS.....IKP............TE....SPPNM......SS...........RPS..S...P....ATT......LRKFS..P......................................................................SP.T..HTSPLA....LV
  936- 1041 (179.19/63.28)	G..........KS...SPTLK.QST.N.KPV..QSPKHS..P.......VYSS...SPKHTPVPAS.....VSPK.HG........TS....SPKHG......SSA...S....TGKPS..M...S....ALK......SAANS..PSSKTTD....................................SGQSKIKSSSSSS..S.KD.....SNREKE.R..KTSSLA....FG
 1042- 1142 (83.45/24.66)	G..........SSghqSPKTK.SSS.G.K......LKQL..E.......LIPS...GETQSTMPSS...ggSTPP.SG........NSelgkSAIAQ......QQA...R....NRKGS..L...S....AVI......DKLKN..AQHCTDD....................................GSNGGAKSTTGSS.....N.....SSGQKE.R..............
 1144- 1223 (80.08/23.30)	...................VG.SSS.N.KTA..EG...K..C.......INKN...SSMDTKNPAE.....YMVK.H.........................................S..S...D....GMK......ITINK..TRTKDSK....................................SG.TNLKLSSSSA..S.VA.....TGTSSS.S..STSSTN....IS
 1224- 1318 (87.36/26.24)	G..........NS...SP..K.THT.GlKP...................GVSS...GPASKKPPTQ.....TSPKlSG........SS....SSSSG......SSG...NkttlLGQKM..L...S....ALK......SISGS..NSGSGNG....................................TGGINVGSSGSSGllS.KN.....VMSSKS................
 1319- 1381 (56.43/13.76)	......................................S............SS...SPKT..........................TS....SGVTD......LSR...N....RDKSR..L...S......K......SSDKSifPS.........................................KGIGDRKSSPSGL..R.EE.....S..ESE.R..AFKLLA.....A
 1382- 1468 (53.02/12.39)	H..........AS...MSNLS.NLP.N.LP.....PQL...........VVEG...LMKQLDTKFQ.....I.....................PKLS......ARAnadS....TDKKSekL...S....ML...........P..DSGKTLD.............................nlaskqtSEQGKMQTLSNTS..S.TT.....SK....................
 1545- 1621 (63.39/16.57)	......................NRS.N.TQF..QS...S..S.......LNST...GIGKDDISASgpvmaVLPK.GS........EA....QP.........TSK...S....V.YPT..MmttG....TLT......SGNGT..TSTNTGN....................................GG.................................TESLN....LS
 1622- 1710 (74.95/21.23)	I..........KP.vdATMTKyKSD.E.KKQ..QQPQQQ...........QQS...QPPQQQQPQS........Q.QQ........SS....QSQQQ......SQQ...Q....QSQPQ..Q.........VP......SSGGS..SSS...S....................................SLGTTVSSENSSS..AmKA.....TSTE..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.74|      27|      27|     192|     218|       2
---------------------------------------------------------------------------
  192-  218 (44.40/30.07)	SALQSLESDLGILAQLQTFIKEPFNLV
  221-  247 (48.34/33.43)	SPVGILERRRGGHAMKLTYFVSPFDLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.56|      16|      36|    1476|    1492|       3
---------------------------------------------------------------------------
 1476- 1492 (26.13/22.15)	SQGRRDHVQTkPDNLSM
 1515- 1530 (29.43/19.51)	SSGSTHDLDI.PTNLSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.71|      33|      42|      22|      63|       4
---------------------------------------------------------------------------
   22-   54 (54.07/51.23)	MDKGKEWQMELLMEKLRS..KASTYKSLVETAKNL
   65-   99 (47.64/25.09)	IDSAEKSQLQKCLDTLQHsiKVTSLQSMVERLESL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.17|      21|      27|     250|     270|       5
---------------------------------------------------------------------------
  250-  270 (36.91/25.22)	ENRTCDAL..SSEIVIKRK.IGHS
  276-  299 (26.26/15.55)	EGSTAHKLptSSIITVNRSpTGKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.73|      21|      27|     138|     158|       6
---------------------------------------------------------------------------
  138-  158 (38.30/28.54)	DVKIHHEG..KNEQQSCDVLVSC
  166-  188 (31.43/21.93)	DFTVQLEGlaSIYQLNADKKVKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.52|      15|      23|     327|     344|       7
---------------------------------------------------------------------------
  327-  344 (18.88/28.18)	PMcMELVrrIQKVTE..LEC
  352-  368 (22.64/15.33)	PL.LSLI..IQHASEgqLDC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01495 with Med1 domain of Kingdom Metazoa
Unable to open file!