<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01464

Description Mediator complex subunit 6
SequenceMSMAVTTSNGLRHQAATRRTAKTQFLRDHLFTIMASVDFRDNLLGISWVDSGWVPILNPGNVLDYFSERSNPFYDRTCNNEIVKMQRLTLEHLNQMVGVEYILLHAQEPILYIIRKQQRQSPTQVIPLADYYIIAGVVYQAPDLGTVISSRVLSAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDQEEREKTKPKSKKKEEPSSLFQRHRVDTLLLDLRSKFPPTFYQPKPGDKPIPVEVKKEPEPPTEAAKQEEREPATKSSAPAPPSKPPPEKRARLQ
Length279
PositionHead
OrganismPoecilia formosa (Amazon molly) (Limia formosa)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Poecilia.
Aromaticity0.09
Grand average of hydropathy-0.649
Instability index57.15
Isoelectric point9.25
Molecular weight32042.23
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01464
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.02|      11|      18|     112|     122|       2
---------------------------------------------------------------------------
  112-  122 (20.77/15.34)	YIIRKQQRQSP
  132-  142 (20.25/14.78)	YIIAGVVYQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.95|      11|      18|     201|     211|       3
---------------------------------------------------------------------------
  201-  211 (20.02/ 9.43)	PSSLFQRHRVD
  222-  232 (22.93/11.67)	PPTFYQPKPGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01464 with Med6 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FYQPKPGDKPIPVEVKKEPEPPTEAAKQEEREPATKSSAPAPPSKPPPEKRARLQ
225
279










Molecular Recognition Features






MoRF SequenceStartStop




1) APPSKPPPEKRARLQ
2) KPIPVEVKKEPEPPTEAAKQEEREPATKSSA
265
233
279
263