<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01460

Description Mediator complex subunit 14
SequenceMAPVQIGSDGPLVPLGGPVVSGPQPPPPGTPATQGVKLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAILFVDTADRLALLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKTEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSLQVNFIHELVQARLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEEKYVPAKYLTLSVWNQQVLGRKTGTASVHKVTIKIDESDGSKPLQISHEPALPACDSKLMERAMKIDHLSVEKLLIDSVHARAHQKLQELKAILKTSNPSDNSFIETALPTLVVPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSMLDDIEKTVNDDMKRILSWLQQLRFWLGEQRCRQSVKHLPTVCSDILHLSNSATHPVGSLSKHKLFIKLTRLPQYYIVVEMLEVPSSPTALQYKYSFLSVSQLEGEDGPMCAQLLQLFKPNLEHLVQDPTTGREARPGTKRKIAGDQGDSEPKKPKRSGEMCAFNKELAHLVAMCDTNMPFIGLRAELSNMAIPNEGVQVEGDGSSHAIRLLRIPPCRDVGEETRRALERSLLDSTIRLQGRNNRTWVAELVLANCPLSSTNSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWKAISQLYQCVLNFSCTLPEMPPYLSQFSEVRLYNYRKLVLCYGTTKGSSVTIQWNSNTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPNVMQLLQVLYDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSSQDARRRSVNEDDNPPSPVGVDVMDSLMNQLQAQQQPQTMRGGAGGVYPPLTSPPPNYLANVTPSPSMMPTQSPGNIHASGSPSGALRAPSPFGPTPSPSSLGIAMGQTSFASPHGPLDPSSPYTMVSPSHRGQWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPNSPRAGSGSQVMPTSMPPPRKLPQRPWAASIPTILSHNALHVLLLPSPTPCMVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEATLSIVNSNEPGVIMFKTDVLKCRVALNPKNYQTLQLKVTPENAGPWSQEELQVLERFFETRVAGPPFKFNTLSAFTKLLGAPTNVLRDCVRIMKLELFPDQAGQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKAKMLFFLQLTQRIPVPQDPVSIIVPIVYDMATGLTQQADIPRQHSSSGAAALLVSNILKRFNELHPSRQGECTIFASVQELMASLTLPPSTRQ
Length1435
PositionTail
OrganismPoecilia formosa (Amazon molly) (Limia formosa)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Poecilia.
Aromaticity0.06
Grand average of hydropathy-0.178
Instability index51.34
Isoelectric point8.66
Molecular weight158767.80
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
blood vessel morphogenesis	GO:0048514	IEA:Ensembl
embryonic viscerocranium morphogenesis	GO:0048703	IEA:Ensembl
neural crest cell differentiation	GO:0014033	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl
ventricular system development	GO:0021591	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01460
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.70|      19|      34|     991|    1010|       1
---------------------------------------------------------------------------
 1083- 1103 (24.77/ 8.57)	VSPSHRGQ.......wpGSPQ.VSGPSPG
 1104- 1132 (18.02/ 7.91)	ARIPGMSPgnpslhspiPDPNsPRAGSGS
 1133- 1153 (22.91/ 7.28)	QVMPTSMP......pprKLPQ..RPWAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.96|      11|     130|     892|     902|       2
---------------------------------------------------------------------------
  892-  902 (21.73/12.47)	SILP.QSPTHIR
 1023- 1034 (19.23/ 9.99)	SMMPtQSPGNIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     536.43|     148|     149|     218|     366|       3
---------------------------------------------------------------------------
   89-  236 (146.93/92.59)	L...VK.WASNAGKvekcAMISS....FLDQ..QAI.LfvdTADRLALlaRDalVH..............ARLPSFAIPFAIDVLTTGSY.........PRLPTCIR.DKIIPPDPITktekQTTLNQlnQI...LRHRLVTTDLPpqlanltvangRVKFRVEGE.......................................................fEATLTVMGD..DPDIPWRLLK
  237-  378 (222.33/148.56)	LEILVEDKETGDGR....ALVHSLQVNFIHELVQAR.L...CADEKPL..QD..MY..............NCLHSFCLSLQLEVLHSQTL..MLI...RERWGDLVQeEKYVPAKYLT....LSVWNQ..QV...LGRKTGTASVH...........KVTIKIDESDGSKPLQISHEPALP..................................................acDSKLMERAMK
  379-  576 (167.17/106.51)	IDHLSVEK..........LLIDSVHARAHQKLQELKaI...LKTSNPS..DN..SFietalptlvvpilePCGRSECLHIFVD.LHSGMFqpMLYgldQSMLDDI...EKTVNDDMKR....ILSWLQ..QLrfwLGEQRCRQSVK...........HL.....PTVCSDILHLSNSATHPvgslskhklfikltrlpqyyivvemlevpssptalqykysfLSVSQLEGE..DGPMCAQLLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     649.68|     207|     495|     666|     889|       4
---------------------------------------------------------------------------
  666-  889 (334.38/208.19)	SH.AIRLLRIP...PCRDVGeetrraLERSLLDSTI.RLQGR.NNRTWVAELVLANCPLSSTNSKEQAST..RHVYLTYE...NPLSEPVGGRKVVEMFLNDWKaiSQLYQCVLNFSCTLPEMPPY....LSQFSEVRLYNYRKLVLCYGTTKGSSVTIQWNS...NTQrFHLALGTVGPNSGCSNCHNIILhQLQEMFnknpnVMQLLQVLYDTQAPLNAInkLPTV.PM.LGLTQRTNTAYQ
 1159- 1385 (315.30/164.26)	SHnALHVLLLPsptPCMVPG......LAGSYLCSPLeRFLGSvIMRRHLQRIIQQEATLSIVNSNEPGVImfKTDVLKCRvalNPKNYQTLQLKVTPENAGPWS..QEELQVLERFFETRVAGPPFkfntLSAFTKLLGAPTNVLRDCVRIMKLELFPDQAGQlkwNVQ.FCLTIPPSAPPIAPPGTIAVVL.KAKMLF.....FLQLTQRIPVPQDPVSII..VPIVyDMaTGLTQQADIPRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.88|      12|      30|    1038|    1049|       5
---------------------------------------------------------------------------
 1038- 1049 (23.74/11.58)	SPSGALRAPSPF
 1069- 1080 (26.15/13.62)	SPHGPLDPSSPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.97|      30|      33|     942|     974|       8
---------------------------------------------------------------------------
  945-  974 (53.04/34.28)	G...LKTFLNMFVDSSQDARRRSVNEDDNPP..SP
  976- 1010 (45.93/20.98)	GvdvMDSLMNQLQAQQQPQTMRGGAGGVYPPltSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01460 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SQDARRRSVNEDDNPPSPVGVDVMDSLMNQLQAQQQPQTMRGGAGGVYPPLTSPPPNYLANVTPSPSMMPTQSPGNIHASGSPSGALRAPSPFGPTPSPSSLGIAMGQTSFASPHGPLDPSSPYTMVSPSHRGQWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPNSPRAGSGSQVMPTSMPPPRKLPQRPWA
2) VQDPTTGREARPGTKRKIAGDQGDSEPKKPKRSGE
957
586
1151
620










Molecular Recognition Features






MoRF SequenceStartStop




NANANA