<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01447

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMEVPGADSDWRSPQFRQKVVAQIEDAMRKAGSGNTTHKSGTDMENHVFIKAKTREEYLSLVARLIIHFRDIHKKALGGAGECSSAPCWVLGGVRLRPGSWGFWQLGQHAMAGVPGNPQASECVSWLRHVEPTPGWLRLQNRVIPALPVSLQWALRVHKLTQQNQQQDRVQIPSGFWRCSDSIYLRALSPTNAAACCIHTNSVHPQSATLPSAGGSWFLQFSAADASSDVCQQLLPVLQLSFPVSSDASDAAQSIQQIVQQQQVQVQPGQMPPHSQPGLVPQSLPGQMPAQSISINSLNQQQLKMQAFQVGLDWCNRAQQNRTRLKLDQPHHLHIKQARATLPLQQAQQAAAHAQLNAAAAAAAAAAVPGQMVRPPMQNLPRPPRPPLNATIPPPSSTAGVGGQMMTTQVPQHPMMSSPSPGQARPGKTAPRRPHPFPLPVNHFLFPVCSSGPTPSPGGFQPSPSPQPSPSPVTARTPQQNHGVASPGPLNTPGNPGSAMSPAGATSLEEQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPTIRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPTKQQYLCQPLLDAVMANIRSPVFNHSLYRTFAPAMSAIHEPPITGPNVCGRKRKHEEDERQTIPNILQGEVARLDVKFLVNLDPAFCSNNGTVHLICKLDDKNLPSVPPLQLSVPADYPDQSPHWADDGDQYGANGFLQTVHRNMTSKLLQLPDKHSVTELLNTWAQSVRQACLSAA
Length767
PositionTail
OrganismPoecilia formosa (Amazon molly) (Limia formosa)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Poecilia.
Aromaticity0.05
Grand average of hydropathy-0.451
Instability index66.58
Isoelectric point9.37
Molecular weight83710.78
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01447
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     171.67|      30|      30|     411|     440|       1
---------------------------------------------------------------------------
  257-  281 (26.01/ 7.31)	IvqqqqvqvQPGQMPPHSQPGL.....V...................................P.Q
  377-  422 (32.43/11.37)	............QNLPRPPRP...PLNAtipppsstagvggqmmttqvpQH..PMMSS...PSPGQ
  423-  458 (48.38/21.46)	A........RPGKTAPRRPHPF..PLPV....................nHFlfPVCSSgptPSPGG
  459-  473 (29.87/ 9.75)	F........QP...SP.SPQP....................................S...PSPVT
  474-  503 (34.97/12.98)	A........R....TPQQNHGVasPGPL..................ntpGN..P.GSA...MSPAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.87|      32|      35|      68|     100|       2
---------------------------------------------------------------------------
   68-   97 (45.39/27.90)	....FRDIHKKALGG.AGECSSAPC..WvLGGVRLRP
   98-  133 (53.04/29.09)	GSWgFWQLGQHAMAGvPGNPQASECvsW.LRHVEPTP
  214-  230 (24.44/ 9.17)	GSW.FLQFS.......AADASSDVC............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.25|      26|      26|     543|     568|       3
---------------------------------------------------------------------------
  513-  536 (36.91/19.25)	MEKLKQLSKYI.EP.LRRMINKIDKN
  543-  568 (43.10/23.87)	LSKMKSLLNILTDPTIRCPLKTLQKC
  572-  597 (46.24/26.20)	LEKLKNDMAVPTPPPPPVPTKQQYLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.84|      16|      92|     140|     171|       4
---------------------------------------------------------------------------
  145-  164 (24.44/38.11)	ALPVSLQWALRvhklTQQNQ
  306-  321 (32.40/ 7.73)	AFQVGLDWCNR....AQQNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.37|      12|      37|     251|     264|       5
---------------------------------------------------------------------------
  251-  264 (16.71/ 9.83)	AQSIQ.qiVQQQQVQ
  289-  303 (15.66/ 6.82)	AQSISinsLNQQQLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01447 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQNRTRLKLDQPHHLHIKQARATLPLQQAQQAAAHAQLNAAAAAAAAAAVPGQMVRPPMQNLPRPPRPPLNATIPPPSSTAGVGGQMMTTQVPQHPMMSSPSPGQARPGKTAPRRPHPFPLPVNHFLFPVCSSGPTPSPGGFQPSPSPQPSPSPVTARTPQQNHGVASPGPLNTPGNPGSAMSPAGATSLEEQQYMEKLKQ
318
518










Molecular Recognition Features






MoRF SequenceStartStop




NANANA