Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MAAGPGVSMQSGSPARELSISVQQGSSQTFGERIKTEDVTEAEKQSRMAALLERLHAKHNASRPWEGTINVVRQAMEKRSVMNEAGHQLLLNCLETLQRALKVSSLPSMTDRLESIARQNMLGSHLSTTKTECYITSDMFYVEVQLDTGGQLVDVKVAHQGENPTSCSELIQHLSEKNFEAFSKHLKGLVDLYRLPGDNKLKTKMYIALQSLELDLTKMMTMFRLATNANTVETILHGSVGWLTPRSGGNLVSLQCYVSPYDIFEVETGSQLSLPDNNVPRSLGVSVSVTIEGTSAVYKLPIAPLITGSHPVDNKGTPSFSTVSNSNSVDLPACFFLKMNRPMPFSLSFIQRLGSATSIPVFETPPPLSLLYQLIVQSQLQLLEEGSATPATLNNMHFYSILPDQHHCYFLNGDAPVQDGHSLQGAMVSKIPFRHPAHVPLLLDIIRHQAAYNTLIGSCVKRTSVKEDSAGLLQFEVCPLTDSSFSVSFQHPVNESLVCVVMEVIDSRQVSCHLYKGPSDALICTDEFITKVVTRCMSIPVTMRAIRRKAETIQADTPALSLIAQTVETMVKNNPPPSGSPPYKMVGGDGTNPMGLPGLTGGNTPTGGGPPGGPNFAGPITSLFGMPRAERQAQGECLTPGGVTGQQPLPQQQQVHSDDYSKVTQNPILTSLLQITGNVGSSPSSQNAPQPHQTPPPTSSPASNTKSHPMLMNLLKDNPTQDFAALYSSSPLERQNSSSGSPRTDSMGGACPSGNTKGKKKRPRGSEKGGVLPGVGAGGGLGMKPQPGSSMPQHLQHHSVSHEDDFHRKLLSMDVDASQNSIFDVNLAGDSLDTHHSITPTLSQCGTPPPGSGMAYSQSHVQTQQQQPGSVPPRIVRLPSSDSIGPDITEILQELPEQTGKGSGGSHGQPEDGGPLGTPIRDSSSSGQGSAVFDSADIFNTNSNENPFTDAADLIAEAAATAATPNSDSSSTNFFPDASDFNPDLLTSGHGFSQSYFDDSSPSADGDMDLVKGFGGGSQQNTPSGTPQNPQHGQSTPEPSLKDPFDMGIVFGGNSGGGKPLLGQAPDLIDTHSGGSQSPLMMGLGGACSDFKTTDPKIKTGLIRPKDENGGNGGSGSGMGSSSAEGKQIKRSRTPSSEGKSKDKPPKRKKLDPDGKSPSHSSGGRPYTPPSGGSGSGGSISGGGSKSPGSSGRSQTPPGGATPPIPKITIQIPKGTITGGKTSSHSGYTSSSSATSSTGGVGGTSSSSKSHHSHSSSSGKIKSKEGSMTQSSSSKPGGSGGGGGQSQMKGSSQGMGVAKSGSSPITKHGLSGPGGAGGGMGSGSKIKPQGGKPPGSLMNPNIKPNISPSHSRSSSSGDKLSSPMKMQQSQVPGTPPSSKAKSPIGSGSGSSGGSKSSSGGSSQKPGGGGSSGSTSSSSTSSSGSMSFSGGSQSQYGSGGSGGGGGGNGNEGNGGGSGGGAGQNNSNNPNSKGKSPSRNKKPSLTAVIDKLKSVGSGGVGEDGCEVGTPVGGPGSTSTPCGPGNVPSGPPNVGSSKHSSSSQSGDYKREKSDKDGKAKVMVTGGGSGDKKMMDPKTSGSGGTTLAKIIISKPDGGSPSIKAKVTLQKPGEGSGESIRQQISGLKASPLFSGSTPKHDRSSPSHSRSPGYTPLNQDSESESGSSSVAEKSHQNSPSSDDDQTVRPLPPQDYMSSIPLSSGEKHKKHKKEKKKLKDKERERDRDRDRDRDKEKKKSSMSMGSSSHSTKADSWSRSPISASDSSLSMLGSDRPSRSSPMYMRNEDDDLMDSALTGDF |
Length | 1793 |
Position | Middle |
Organism | Poecilia formosa (Amazon molly) (Limia formosa) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Poecilia. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.647 |
Instability index | 54.35 |
Isoelectric point | 8.76 |
Molecular weight | 185397.38 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP01436 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 1406.85| 272| 272| 1114| 1385| 2 --------------------------------------------------------------------------- 581- 878 (300.51/55.76) PPYKMVGG.DGT......NPMGLP....GlT...............GGN.............TpTGGG.......PPG...........GPNFAGPITSLFGMPRAERQaqgecLTP................GGVTGQQPLPQQQQVHSddyskvtqnpilTSLLQITGNV.GSSPSS..QNAPQPHQTPPP..TSSPASNTKshpmlmnllkdnptqdfaalysssplerqnsSSGSPRTDSMGGACPS.......GNTKGKKKRP......RGS...EKG..GVL.PGvGAG....GGL..G..MKPQ.....PGSSMPQHLQHH.SVSHeddfHR......KLLS.MDVDASQnsifdvnLAGdsldthhsitptlsqcgTPP..................PG....SGMAYSQSH.VQTQQ........QQ.PGS......VPPRIVRL..... 879- 1156 (332.87/62.63) .PSSDSIGPDITeilqelPEQTGK....G.S...............GGShgqpedggplgtpI.RDSS.....SSGQGSAvfdsadifnTNSNENPFTDAADL...........IAE................AAATAATPNSDSSSTNF............FPDASDFNPD.LLTSGHgfSQSYFDDSSPSA.....DGDMDL...............................VK.....GFGGGSQQNTP....SGTPQNPQHGQ......STPEP......SLKDPF.DMGivfgGNSG.........GGKP...LLGQ..APDLIDTH....SGGSQS..PLMMGLGGACSD.......FKT.................TDPKIKTglirpKDENGgngGSG....SGMGSSSAEGKQIKR........SRTPSSEGKSKDKPPKRKKLDPDGK 1157- 1416 (467.05/91.11) SPSHSSGGRPYT......PPSGGS....G.S...............GGS.............I.SGGG.....SKSPGSS.........GRSQTPPGGATPPIPKITIQ.....IPK................GTITGGKTSSHSGYTSS............SSATSSTGGV.GGTSSS..SKSHHSHSSSSGKIKSKEGSMTQ...............................SSSSKPGGSGGGGGQSQM....KGSSQGMGVAK......SGSSPITKH..GLSGPG.GAG....GGMGSGSKIKPQ.GGKPPGSLMNPNIKPNISPSH....SRSSSSGDKLSSPMKMQQSQ.......VPG.................TPPSSKA.....KSPIG..sGSG....SSGGSKSSSGGS...........SQKPGGGGSS..........GSTSS 1417- 1715 (306.42/57.01) SSTSSSGSMSF.........SGGSqsqyG.SggsggggggngnegnGGG...............SGGGagqnnSNNPNSK.........GKS..PSRNKKPSL...TAV.....IDKlksvgsggvgedgcevGTPVGG........PGS............TSTPCGPGNVpSGPPNV..GSSKHSSSSQSGDYK.REKS.DK...............................DGKAKVMVTGGGSGDKKMmdpkTSGSGGTTLAKiiiskpDGGSPSIKAkvTLQKPG.E.........GSGESIRQQiSGLKA............SPLF....SGSTPKHDR.SSP...SHSR.......SPG................yTPLNQDS.....ESESG...SSSvaekSHQNSPSSDDDQTVRplppqdymSSIPLSSGEKHKKHKKEKKKLKDKE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 213.49| 67| 178| 292| 361| 4 --------------------------------------------------------------------------- 292- 361 (111.32/68.60) EGTSAVYKLPIAPLITGS......HPVDNKGTPSFSTVSNSNSVdlpAC.FFLKMNRPMPFSLSFIQR.LGSATSIPV 467- 541 (102.18/55.88) EDSAGLLQFEVCPLTDSSfsvsfqHPVNESLVCVVMEVIDSRQV...SChLYKGPSDALICTDEFITKvVTRCMSIPV --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 63.94| 19| 24| 1733| 1751| 5 --------------------------------------------------------------------------- 1733- 1751 (35.32/15.59) SSMSMGSSSHS.TKADSWSR 1752- 1771 (28.61/11.11) SPISASDSSLSmLGSDRPSR --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GTTLAKIIISKP 2) IPKITIQIPKG 3) IPLSSGEKHKKHKKEKKKLKD 4) MSFSGGSQSQYGS 5) SIKAKVTLQK 6) SRSSPMYMRNEDDDLMDSAL | 1580 1205 1693 1425 1597 1770 | 1591 1215 1713 1437 1606 1789 |
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