<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01435

Description Mediator complex subunit 12
SequenceMMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSARNVNFNPSKISSNFSSIIAEKLRCNTFADTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGFLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLLEQLQKIAEFYRQCPSQGCSSPLPAMPADVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKVRPGEDELLRLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSLGPGAAGHAAHGILTQQGNALPTTPTSQPAGGNQAQTPFTDFYVCPQHRPLVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSSLPMPGGNTAFTQQVRAKLREIEEQVKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFNNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPTLTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDDSERKEQDAGSSVKMEDTGLSESMETDHNSSANFDEMFSPPMHCESKGSPSPEKPPQEQDGKSSCKDKGLDPAFPQLYEQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKLRDEARHTIKKITKDILKVLNRKSTAETGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLVGSYTTSLCLCIVAVLRRYHSCLILNPEQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCSHLKNKFGEIFSEFCSKVKNSIYCNIDPSDSNMLWDPGFMMETISNPSANNNHSMVGKILNDSPANRYSFVCNVLMEVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGILKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPVPQDGVKSDKSSVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELRGSGLSHPAGLDDISDGRNVSIETASLDVYAKYVLKTICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSDDGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSTNNELCSLLENIAKATIEVFQKSAEMNSSNPSGNGATVQGGSATNSNSTTSKMKPILSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYNQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGGMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKIAKFEEQQRFLLYHTHLKPKPRSYYLEPLPLPPEEEEPLTPISQEPEKKMMEVVKADKSVAAVASESSKKKPKKKKTSTKGEEFLNRTQANMTYVHNVPTETVQTNLYNRIPYGQQPMGVFPQNQPLPPGGPGLEPPYRPNRNTQMPKMITTRPNYPPMDKLYPMSYKPQPSMPQSNLRQQLVVRLQNQNAMGPQMRQMAPNQPYPQMQPSQGYTTYGSHMGMQHPTQGGGIAPSSYVAQNFTGVHPGANPGVVEPLRQMQQRSSGYVHQQAPGYPHNMQNTPRFPHQPIQQGSVMHGLGQLGVQGMYTNLRPNQMLTEQQQAAAQQQQAAQQQQHSFLRHQALRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQQQVQPQQVQQQQQVPQQQQQQVSAVPPPGQTQNQGLGMQPLPPQQPMFPRPGMQQTQQQQQTAALVRQLQQQLSNTQPGQSTSSYY
Length2155
PositionKinase
OrganismPoecilia formosa (Amazon molly) (Limia formosa)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Poecilia.
Aromaticity0.07
Grand average of hydropathy-0.520
Instability index56.19
Isoelectric point6.85
Molecular weight241426.35
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01435
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.33|      17|      17|    2037|    2053|       1
---------------------------------------------------------------------------
 2049- 2067 (30.55/ 8.61)	QQQQ.QqqQQQ...QQQQQQQQQ
 2068- 2085 (25.75/ 6.15)	PQQQvQ..PQQ...VQQQQQVPQ
 2108- 2127 (26.03/ 6.30)	QPLP.P..QQPmfpRPGMQQTQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     217.85|      44|      44|    1803|    1846|       2
---------------------------------------------------------------------------
 1819- 1864 (63.17/25.28)	PP.GGPGLEPPYR.PNRNTQMPKMITTRPNypP........MDKlYP..........MSYKPQ........PsM
 1865- 1916 (45.36/16.09)	PQ.SNLRQQLVVRlQNQNAMGPQMRQMAPN.qP........YPQmQPsqgyttygshMGM..Q......H....
 1938- 1990 (60.06/23.68)	PG.ANPGVVEPLR.QMQQRSSGYVHQQAPG.yPhnmqntprFPH.QP..........IQQGSV......MHG.L
 1991- 2035 (49.26/18.10)	GQlGVQGMYTNLR.PN......QMLTEQQQ..A........AAQ.QQ..........QAAQQQqhsflrHQA.L
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.36|      38|      47|     908|     946|       3
---------------------------------------------------------------------------
  908-  946 (62.45/43.17)	CIVAVLRR.YHSCLILNpEQTAQVFDGLRIVVKS....GVNPAD
  953-  995 (60.91/36.96)	CILAYLYDlYTSCSHLK.NKFGEIFSEFCSKVKNsiycNIDPSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      91.43|      17|     346|     665|     681|       4
---------------------------------------------------------------------------
  650-  668 (23.02/11.70)	SERKEQDAGSSVKmeDTGL
  669-  686 (24.22/12.79)	SESMETDHNSSAN.fDEMF
  687-  699 (17.95/ 7.12)	SPPMHCESKGSPS......
  703-  718 (26.24/14.61)	.PPQEQDGKSSCK..DKGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.63|      12|      52|    2086|    2099|       5
---------------------------------------------------------------------------
 2086- 2098 (22.17/ 9.16)	QQQQQVSAvPPPG
 2137- 2148 (23.46/ 6.02)	QLQQQLSN.TQPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.56|      45|      52|    1044|    1094|       7
---------------------------------------------------------------------------
 1044- 1091 (74.63/72.85)	C.VDHRDPERVNDIGILCAELTA.YC.......RSLSAEwlGILKAlCCSSNNGNCG
 1097- 1150 (63.93/40.60)	CnVDVSDLSFHDSLATFVAILIArQCllledlvRCVAIP..SLLNA.ACSEQDSEPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.09|      15|      15|     836|     850|       9
---------------------------------------------------------------------------
  836-  850 (26.84/17.91)	LEQITSFALG.MSYHL
  852-  867 (23.25/14.43)	LVQHIQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.58|      21|      24|    1534|    1556|      10
---------------------------------------------------------------------------
 1534- 1556 (29.71/28.36)	QQTTewAVL.LLDIISSGTV..DMQS
 1559- 1582 (24.87/14.52)	ELFT..TVLdMLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.36|      23|      24|    1768|    1790|      24
---------------------------------------------------------------------------
 1768- 1790 (41.15/28.58)	TSTKGEEFLNRT...QANM.TYVHNVP
 1791- 1817 (33.21/21.37)	TETVQTNLYNRIpygQQPMgVFPQNQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.88|      15|      97|    1621|    1635|      31
---------------------------------------------------------------------------
 1621- 1635 (29.07/14.57)	LPLPKQTRDVIT...CEP
 1720- 1737 (23.81/10.58)	LPLPPEEEEPLTpisQEP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01435 with Med12 domain of Kingdom Metazoa
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