<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01408

Description Mediator of RNA polymerase II transcription subunit 19 (Fragment)
SequenceMKMGDLRRGDSSYSPKSSPRGSRSPVVPRQDSTGTLKTTISLGRTPSIVHSGPFYLMKEPPKSELTGATNLMSYYNLEHSYNKFCGRKMKDQLSAFLPNLPGNIDGPGNLDNSSLKSLIEKPPIGGKELLPLTGSQLSGFRLHPGPLPEQYRLMSQQPQKKKHKHKKHKHKAGDTPTQESQQDSNLEGPHEKKHKKQKRHDEEKEKKKKKKEKKKKKKHCPDPTTGSSIIPTSGTLP
Length237
PositionHead
OrganismStegodyphus mimosarum
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Chelicerata> Arachnida> Araneae> Araneomorphae> Entelegynae> Eresoidea> Eresidae> Stegodyphus.
Aromaticity0.04
Grand average of hydropathy-1.247
Instability index63.09
Isoelectric point9.98
Molecular weight26487.03
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP01408
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.66|      24|      28|     145|     171|       1
---------------------------------------------------------------------------
  145-  171 (42.85/21.77)	GPLPEQyrlMSQQ......PQKKKHKHKKHKHK
  173-  202 (38.81/14.06)	GDTPTQ...ESQQdsnlegPHEKKHKKQKRHDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.21|      18|      19|       8|      25|       2
---------------------------------------------------------------------------
    8-   25 (33.23/19.23)	RGDSSYSPKSSPRGSRSP
   29-   46 (30.98/17.45)	RQDSTGTLKTTISLGRTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.65|      24|      30|      57|      80|       3
---------------------------------------------------------------------------
   50-   78 (37.45/14.94)	HS...gpfylMKEPPKSELTG.ATNLMSYYNLE
   79-  111 (33.19/12.68)	HSynkfcgrkMKDQLSAFLPNlPGNIDGPGNLD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01408 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AFLPNLPGNIDGPGNLDNSSLKSLIEKPPIGGKELLPLTGSQLSGFRLHPGPLPEQYRLMSQQPQKKKHKHKKHKHKAGDTPTQESQQDSNLEGPHEKKHKKQKRHDEEKEKKKKKKEKKKKKKHCPDPTTGSSIIPTSGTLP
2) MKMGDLRRGDSSYSPKSSPRGSRSPVVPRQDSTGTLKTTISL
95
1
237
42










Molecular Recognition Features






MoRF SequenceStartStop




1) EKKHKKQKRHDEEKEKKKKKKEKKKKKKHCPDPTTGSSIIPTSG
2) HKHKKH
191
163
234
168