<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01403

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceMAGTLTGQSYKDTDITTQRLLSEWHHFYPLRPRNTKDILTDDDHIMSAVEVIVGGIKMRYPSSYVLVTEIDENAAIGQNSGVSQFSSFSNSSSSFCASQQKASLLAGVLTPPTSPCDPSLAANCNFRGHPLGLANETFSDNSTSSYTGYSTAWKIKEAVWQDSALQGRKQVVEGSEQAAFWDFSDPSSLVRCNCSRCKAANQEKNSSLKIPTSSSNTVVSTNSPSASVGSPSCVTTAGGTTAGAVKKVEKPDKLKILNRFRGTVPFHKRNAFSESSEMDSYTASSTFVMTSIPGNSLPNNGNSNFQFKGLNQSLRSSTPSGLPQLHTSVVQPSSLGSPHPGTPLPDGTNSQSTEPAMPTLSPHPPLEKEEETLESQDTSMGTQSPSAIPEPNSNSSIKEKTSAELVSSPHQNTISNLAENIKSEESSDPPPTATNNSTTNSSNNSSNSNNNSWVPGTQEDIKPPVALSSVPSTPAPPSISVQGLKRPSLVVCSHEDPHDELVMDGLLYDYTFLNSSVWESMSAKRRRLWPYTRTRADNLDGYGYPYGKDNLNQMQIDENLSLKPKDPYEFNDEFDEESPSSSSFRARVDEEDIKKEPGLPPTPESQSLTPGQTASAPLTPTQDTPKPPPSGEQPISSPLTPHHHSTDLKSERDLQVTDHDLENIFESSSDESIPDEQFQTASTPTGKLCGTPEDPFSGKCKSSSCTTGILGVAELTRMFPTPPSLEHNTAPSPSGPLCGTDLSTLDSSDCCRERTEGYIDGGSSPYYEPVRDWSFVYKLPVQYKFINSKRYASLTTLPSQLQPVTLSADHIYKPSWTQAISSSPLPANTSLPNSQVIGHVERLPANTNSQFSMMPVNDGERMVPPMFAVENPIDQRTLPMNYELQSPASSASSYLNKHLNSVDSSGTTSSIPEAHSLLVNLVIADSMLNLFKDHNFASCTLCVCNMNTKGADAGINLPSSLIPSGTDEPQYKCTCGFSAVVNRHQSHRAGIFYEDELDITGHRYETFFCRKSLSLVESVSSKKADIGQNMEDETNAQVDHVPHSVVDLIKVQCSHICSTFSIFHKAEQFRSFDRFNSQYNALEISDGCEICFLALDTGRQAVDNMNNNKMDENLKSSCLHKWPYLAAKVPVSNLEVVHLLRSLQPVLQEAVQQRRHQRLWEVTYPVLGPLTWRQFHRLAGRGTEDQCEPQPIPSLLVGYDKDWLALSPFALKYWDKLLLEPYTNSRDVAYVVVAPDSDCVLTHVKKYFKELSTIYELCRLGRHCPITKVLRDGIMRVGKSTAKKLADEPVDDWFSLIGDGPIASRLKLYAQACRYHLAPHLATQPLDSSLLESPPVLKPPDKPLSVASPRTSGTESQDKDQSSFKSTETESKVESSTSTSEQSSTSVNTISDSSDMEDSQQTPTIVIYLVEPFTHGTADADVYRLASLGLLRSYTHMLQFLPEHIRNNIHLQVIPLDSILSLGCMENQEKRKDQLKALAFSVFSQCHQIFLHQAIAKSLTGFGPAAAQDMFLKSRDARNSIFSPPPSKAFTLAPQKDKQTELGEMFGDRREKSSILYCTYCLTEDQRWLVASCTDDKGDVLETCCISIEVPNRTRRKKASVRKLALHKLLDFIVEVLSKCLHAWRLVISRLGRLGHGELRDWASLLSRKSLLRYSRQLRELCHQCAVLGPPDTPAILSACLVSLEPDSALRVMADQYTPDDRFSCNTCDLSTPEDASCTHILVFPTSATTQSSQATFQQEHIDPLSTTLGDDDIFQALNDDDIAVGQDINDIFRWTESPPQSPGSPRRDSISQPGSPSCGMGGRQSPFHHGGPNRGSGNLSMDTQEEPLQLLQQPLALGYYVSTAKTGPLPKWFWSTCPQLQNVCPVFLKSALLIHSPSVQQSSDDLLHANPHTRNYHPLDSNLTTDVLRYVLEGYNSLSWLSLDPSTHDRRSCLPVHIQVLMQLYQAVEALI
Length1953
PositionMiddle
OrganismStegodyphus mimosarum
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Chelicerata> Arachnida> Araneae> Araneomorphae> Entelegynae> Eresoidea> Eresidae> Stegodyphus.
Aromaticity0.07
Grand average of hydropathy-0.478
Instability index55.38
Isoelectric point5.53
Molecular weight214953.00
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01403
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.03|      16|      17|     389|     404|       1
---------------------------------------------------------------------------
  389-  404 (26.66/14.71)	PEPNSNSSIKEKTSAE
  409-  424 (26.36/14.46)	PHQNTISNLAENIKSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.77|      15|      17|    1784|    1800|       2
---------------------------------------------------------------------------
 1786- 1800 (29.71/17.51)	PRRDSISQPGSPSCG
 1802- 1816 (31.07/11.88)	GGRQSPFHHGGPNRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     103.02|      17|      17|     602|     618|       3
---------------------------------------------------------------------------
  340-  351 (22.37/ 7.16)	PGTPLPD.........GTNSQ
  430-  446 (25.43/ 9.41)	PPTATNNSTTNS....SNNSS
  600-  616 (28.43/11.62)	PPTPESQSLTPG....QTASA
  617-  637 (26.79/10.42)	PLTPTQDTPKPPpsgeQPISS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.57|      15|      15|     814|     828|       4
---------------------------------------------------------------------------
  814-  828 (28.29/13.08)	PSWT..QAISSSP.LPAN
  832-  846 (20.98/ 7.81)	PN.S..QVIGHVErLPAN
  865-  881 (23.30/ 9.49)	PMFAveNPIDQRT.LPMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     494.58|     173|     189|    1220|    1407|       5
---------------------------------------------------------------------------
  718-  775 (58.54/27.60)	........MFPTPPSLEHNTAP.SPSGP.LCGTDLSTLDSSDCCRERTEGYI.....................................................................................................................dggsspyyEPVRDWsF..................................
 1220- 1321 (103.26/85.32)	..........................................................................................EPYTN.SRDVAYVVVAPdsdcvLTHVKKYFKELSTIYELCRLGRH...CPItkvlrDGIMRVG........KSTAKKLA.......dEPVDDW.FSLIGD.......GPIASRLKLYAQACRYHLapHL
 1322- 1512 (249.28/154.76)	ATQPLDSSLLESPPVLKPPDKPLSVASPRTSGTESQDKDQSSFKSTETESKVESST.STSEQSSTSVNTISDssDMEDSQQTPTIVIylvEPFTHgTADADVYRLAS.....LGLLRSYTHMLQFLPEHIRNNIHlqvIPL.....DSILSLGcmenqekrKDQLKALA...............FSVFSQchqiflhQAIAKSLTGFGPAAAQDM..FL
 1513- 1588 (83.50/40.70)	KSRDARNSIF.SP....PPSKAFTLAPQKDKQTELGE....MFGDRREKSSILYCTyCLTEDQRWLVASCTD..DKGDVLETCCISI....................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.81|      15|      15|     648|     662|       7
---------------------------------------------------------------------------
  648-  662 (23.81/11.89)	LKSERDLQVTDHDLE
  665-  679 (24.00/12.04)	FESSSDESIPDEQFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.52|      17|      17|    1624|    1640|       8
---------------------------------------------------------------------------
 1624- 1640 (30.74/22.67)	WRLVISRLGRLGHG.ELR
 1642- 1659 (24.78/16.60)	WASLLSRKSLLRYSrQLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.29|      38|      44|     171|     210|       9
---------------------------------------------------------------------------
  138-  166 (23.88/ 9.74)	............FSDNSTSSYTGYStawKIKEAVW..QDSALQ.
  171-  210 (59.46/49.21)	VVEGSEQAAfwDFSDPSSLVRCNCS...RCKAANQ.EKNSSLKI
  218-  256 (53.95/35.49)	VVSTNSPSA..SVGSPSCVTTAGGT...TAGAVKKvEKPDKLKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.59|      19|     543|     547|     568|      10
---------------------------------------------------------------------------
  549-  567 (35.69/23.57)	DNLNQMQIDENL..SLKPKDP
 1103- 1123 (34.90/14.58)	DNMNNNKMDENLksSCLHKWP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.20|      23|     149|     316|     339|      13
---------------------------------------------------------------------------
  316-  339 (39.56/21.66)	SSTPSgLPQLHTSVVQ....PS....SLGSPH
  468-  498 (35.64/14.93)	SSVPS.TPAPPSISVQglkrPSlvvcSHEDPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.72|      27|     499|     499|     525|      14
---------------------------------------------------------------------------
  499-  525 (50.15/37.08)	DELVMDGLLYDYTFLNS..SVWESMSAKR
  995- 1023 (42.57/30.14)	DELDITGHRYETFFCRKslSLVESVSSKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.60|      14|     499|      84|      97|      15
---------------------------------------------------------------------------
   84-   97 (27.25/15.50)	QFSSFSNSSSSFCA
  573-  586 (26.35/14.69)	EFDEESPSSSSFRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.26|      11|      20|     352|     362|      21
---------------------------------------------------------------------------
  352-  362 (21.25/12.30)	STEPAMPTLSP
  375-  385 (21.01/12.06)	SQDTSMGTQSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01403 with Med13 domain of Kingdom Metazoa
Unable to open file!