<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01379

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMGDTITSLSLVELRALLLEAVRQAHDGLHAVAGALPGLEDSERKRALMSQLHASRQQLQRLGVVVAWSAKARAVAECRRVMQAAAVHAAALQDAADQLAYLHSELTATAAPAYDIATAVQVTEQGSYNLLPSSIEEHAGVSPARPPRSTVRAALAQLDFLIRAKLLQNPRPEGMAVRSISAGVLTLGGAGGLYTARLTLVPAPEERVAQVPQAWARAEGDGAPAVGGPASSAASAPATAKVKHPAAGWRWRLLSLDLLPEYRGREGLAPPQLLAWLQSVLEQRMWAAADVATLRGAGLGDLVAVGDPGAAGDARPTSSERSAPTSDAPGASSLPARSTLCLGAAGLGDESSGHEKCGAGSGPAPSPSPGPDALRLMHEALTRGAARAALASIVVPDARRLEGAEGWAGRLRLERAREGTGIRLRYWLDHPPVTLHELEALQGRSSNGSGAALPATSHALAAPDASAAAHAPPEAPAQAPSIEVALGADAESLAVQLPEAGLLQRVLAARAAMQLAALEGHLSAAPLGACMRCRLVVAEKEAVEPWSAAHEDVPITIATDPQPARLPRLEVWAGGCHDAGDTDGEASPASRPALTLGVDRQTGQYELLQVGEEARGGDAAGVTRPEAATTVAPPSGAGAAAGSSRAGVATASPEPSPLRRELSGALAAAAREALASPLPVGRSRATQAVALAAAVAEARLYEATARGLALRQLGAPPLPGALWLGDAGAGRGPLDGCVPAEPANGAAPTRKRGRGWPEGAVEPTGAPGAEAPVMAKALSPGPPQRRLTLVQALRWARREGLWRQLGHQLDAQGLAASEEWRWVGAPESGGPSPMGGAAHAKPGAAGLAAREFLGGSASEPAPCGAYARFWLHGDRGEWRGELDSRYFASRAARLRDAGVELQDGCDGKAPAVEVVRCGRRGLELAGSFQRGQSVLRGVAALLSSLRLHLCLARCMARCRAAPEVEHENGEVAGEEGAAHANGGAEAKRTVSACTWRLPGSCRCRLASAGLLSATFVVEGRGPSAHGPLLTAEVSWETLGAGRGTGGGAGPGVSELGTPRASGGSPECRVLCRPEVPAALAARLAALLEAGPAGAPAPETAASVADADVQPSLDSSSKPAAAVASAPGTAEGDAAGRDPPPRTCTLWIPEAAVEQAATTVLQAVGGAW
Length1166
PositionTail
OrganismAuxenochlorella protothecoides (Green microalga) (Chlorella protothecoides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> core chlorophytes> Trebouxiophyceae> Chlorellales> Chlorellaceae> Auxenochlorella.
Aromaticity0.03
Grand average of hydropathy-0.101
Instability index51.63
Isoelectric point6.34
Molecular weight118614.47
Publications
PubMed=25012212

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01379
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     745.00|      91|      91|     353|     443|       1
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  228-  312 (86.23/13.79)	.PA.SSAASA......PA...TAKV.K....HP..A.........A......GWRWRLLSLdLLPEYR.............GREG.LA...PPQ.......LL......AWLQ..S..VL.EQ....RMWAA..................ADVA..TLRgaGLGDLVAV..................G..DPGAA...G..D
  361-  469 (143.83/27.70)	GPA.PSPSPG......PD...ALRL.M....HE..A.LT.....RG......AARAALASI.VVPDAR.......R...LEGAEG.WA...GRL.......RL....ERAREG..T..GI.RL....RYWLD..................HPPV..TLH..ELEALQGRssngsgaalpatshalaaP..DASAA...A..H
  470-  556 (66.59/ 9.05)	APP.EAPAQA......PSievALGA.D....AE..S.LAvqlpeAGllqrvlAARAAM.................Q...LAALEG................HL....SAAPLG..A..CM.RC....R.........................L..VVA..EKEAVEPW...............saaH..EDVPI...T..I
  557-  647 (62.39/ 8.03)	ATD.PQPARL......P....RLEV.WaggcHD..AgDT.....DG......EA..........SPAS.......RpalTLGVDR.QT...GQY.......ELlqvgEEARGGdaA..GVtRP....EAATT.................vAPPS..GAG.....AAAGS.....................SR..A...G..V
  648-  757 (76.55/11.46)	ATA..SPEPS......P.....LRReL....SG..A.LA......A......AAREALAS..PLPVGR......sR...ATQAVA.LA...AAV.......AE....ARLYEA..TarGL.AL....R.QLG..................APPLpgALW..LGDAGAGR.gpldgcvpaepangaapT..RKRGR...GwpE
  758-  826 (79.15/12.08)	GAVePTGAPG......AE...A.PV.M....AK..A.LS.....PG..................PPQR.......R...LTLVQA........L.......RW....AR.REG..L..WR.QL....G..............................H..QLDA.QGL.............aaseeW..RWVGA...P..E
  827-  931 (70.24/ 9.93)	SGG.PSPMGG.aahakPG...A..........A..G.L..............AAREFLGGS.ASEPAPcgayarfW...LHGDRGeWR...GELdsryfasRA....ARLRD...A..GV.EL....QDGCD................gkAPAV..EVV..RC.GRRG.....................lELAGSfqrG..Q
  936- 1041 (70.30/ 9.94)	GVA.ALLS.............SLRL......HL..C.LA.....RC......MARCRAAPE.VEHENG.......E...VAGEEG.AAhanGGA.......EA....KRTVSA..C..TW.RLpgscRCRLAsagllsatfvvegrgpsaHGPL..LTA..EV.........................swETLGA...G..R
 1042- 1135 (89.73/14.64)	GTG.GGAGPGvselgtPR...ASGG.S....PEcrV.LC.....RP......EVPAALAAR.L...AA.......L...LEA..G.PA...GAP.......AP....ETAASV..A..DA.DV....QPSLD..................SSSK..PAA..AVASAPGT..................A..EGDAA...G..R
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.57|       9|      25|     142|     151|       3
---------------------------------------------------------------------------
  142-  151 (14.20/ 9.46)	PaRPPRSTVR
  169-  177 (18.36/ 7.89)	P.RPEGMAVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.09|      22|      26|      78|     103|       5
---------------------------------------------------------------------------
   81-  103 (32.93/23.36)	MQAAAVH....AAALQdAADQLAY..LHS
  105-  132 (27.16/ 7.46)	LTATAAPaydiATAVQ.VTEQGSYnlLPS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01379 with Med14 domain of Kingdom Viridiplantae
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